Efficacy and Tolerability of the New Antiepileptic Drugs, II: Treatment of Refractory Epilepsy: Report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society
dc.contributor.author | French, Jacqueline A. | en_US |
dc.contributor.author | Kanner, Andres M. | en_US |
dc.contributor.author | Bautista, Jocelyn | en_US |
dc.contributor.author | Abou-Khalil, Bassel W. | en_US |
dc.contributor.author | Browne, Thomas | en_US |
dc.contributor.author | Harden, Cynthia L. | en_US |
dc.contributor.author | Theodore, William H. | en_US |
dc.contributor.author | Bazil, Carl | en_US |
dc.contributor.author | Stern, John | en_US |
dc.contributor.author | Schachter, Steven C. | en_US |
dc.contributor.author | Bergen, Donna | en_US |
dc.contributor.author | Hirtz, Deborah | en_US |
dc.contributor.author | Montouris, Georgia D. | en_US |
dc.contributor.author | Nespeca, Mark | en_US |
dc.contributor.author | Gidal, Barry | en_US |
dc.contributor.author | Marks, William J. | en_US |
dc.contributor.author | Turk, William R. | en_US |
dc.contributor.author | Fischer, James H. | en_US |
dc.contributor.author | Bourgeois, Blaise | en_US |
dc.contributor.author | Wilner, Andrew | en_US |
dc.contributor.author | Faught, R. Edward | en_US |
dc.contributor.author | Sachdeo, Rajesh C. | en_US |
dc.contributor.author | Beydoun, Ahmad A. | en_US |
dc.contributor.author | Glauser, Tracy A. | en_US |
dc.date.accessioned | 2010-04-01T14:43:31Z | |
dc.date.available | 2010-04-01T14:43:31Z | |
dc.date.issued | 2004-05 | en_US |
dc.identifier.citation | French, Jacqueline A.; Kanner, Andres M.; Bautista, Jocelyn; Abou-Khalil, Bassel; Browne, Thomas; Harden, Cynthia L.; Theodore, William H.; Bazil, Carl; Stern, John; Schachter, Steven C.; Bergen, Donna; Hirtz, Deborah; Montouris, Georgia D.; Nespeca, Mark; Gidal, Barry; Marks, William J.; Turk, William R.; Fischer, James H.; Bourgeois, Blaise; Wilner, Andrew; Faught, R. Edward; Sachdeo, Rajesh C.; Beydoun, Ahmad; Glauser, Tracy A. (2004). "Efficacy and Tolerability of the New Antiepileptic Drugs, II: Treatment of Refractory Epilepsy: Report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society." Epilepsia 45(5): 410-423. <http://hdl.handle.net/2027.42/65170> | en_US |
dc.identifier.issn | 0013-9580 | en_US |
dc.identifier.issn | 1528-1167 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/65170 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15101822&dopt=citation | en_US |
dc.description.abstract | Purpose: To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs (AEDs) [gabapentin (GBP), lamotrigine (LTG), topiramate (TPM), tiagabine (TGB), oxcarbazepine (OXC), levetiracetam (LEV), and zonisamide (ZNS)] in the treatment of children and adults with refractory partial and generalized epilepsies. Methods: A 23-member committee, including general neurologists, pediatric neurologists, epileptologists, and doctors in pharmacy, evaluated the available evidence based on a structured literature review including MEDLINE, Current Contents , and Cochrane Library for relevant articles from 1987 to March 2003. Results: All of the new AEDs were found to be appropriate for adjunctive treatment of refractory partial seizures in adults. GBP can be effective for the treatment of mixed seizure disorders, and GBP, LTG, OXC, and TPM for the treatment of refractory partial seizures in children. Limited evidence suggests that LTG and TPM also are effective for adjunctive treatment of idiopathic generalized epilepsy in adults and children, as well as treatment of the Lennox–Gastaut syndrome. Conclusions: The choice of AED depends on seizure and/or syndrome type, patient age, concomitant medications, and AED tolerability, safety, and efficacy. The results of this evidence-based assessment provide guidelines for the prescription of AEDs for patients with refractory epilepsy and identify those seizure types and syndromes for which more evidence is necessary. | en_US |
dc.format.extent | 125368 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Science Inc | en_US |
dc.rights | 2004 International League Against Epilepsy | en_US |
dc.title | Efficacy and Tolerability of the New Antiepileptic Drugs, II: Treatment of Refractory Epilepsy: Report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | **** Department of Neurology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | * University of Pennsylvania, Philadelphia, Pennsylvania | en_US |
dc.contributor.affiliationother | † Department of Neurological Sciences, Rush Medical College, Chicago, Illinois | en_US |
dc.contributor.affiliationother | †† The Cleveland Clinic Foundation, Cleveland, Ohio | en_US |
dc.contributor.affiliationother | § Vanderbilt University Medical Center, Nashville, Tennessee | en_US |
dc.contributor.affiliationother | Boston University Medical Center, Boston, Massachusetts | en_US |
dc.contributor.affiliationother | ¶ Weill Medical College of Cornell University, New York, New York | en_US |
dc.contributor.affiliationother | ** National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland | en_US |
dc.contributor.affiliationother | †† Columbia Presbyterian Medical Center, New York, New York | en_US |
dc.contributor.affiliationother | †† Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts | en_US |
dc.contributor.affiliationother | §§ Children's Hospital, San Diego, California | en_US |
dc.contributor.affiliationother | School of Pharmacy and Department of Neurology, University of Wisconsin Hospital and Clinics, Madison, Wisconsin | en_US |
dc.contributor.affiliationother | ¶¶ University of California San Francisco Epilepsy Center, San Francisco, California | en_US |
dc.contributor.affiliationother | *** Nemours Children's Clinic, Division of Neurology, Jacksonville, Florida | en_US |
dc.contributor.affiliationother | ††† University of Illinois College of Pharmacy, Department of Pharmacy Practice and Neurology, Colleges of Pharmacy and Medicine, Chicago, Illinois | en_US |
dc.contributor.affiliationother | ††† Department of Neurology, Children's Hospital, Boston, Massachusetts | en_US |
dc.contributor.affiliationother | §§§ Providence, Rhode Island | en_US |
dc.contributor.affiliationother | Department of Neurology, University of Alabama School of Medicine, Birmingham, Alabama | en_US |
dc.contributor.affiliationother | ¶¶¶ Department of Neurology, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey | en_US |
dc.contributor.affiliationother | †††† Department of Neurology, Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A. | en_US |
dc.identifier.pmid | 15101822 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/65170/1/j.0013-9580.2004.06304.x.pdf | |
dc.identifier.doi | 10.1111/j.0013-9580.2004.06304.x | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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