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Dissection of Hypothalamic-Pituitary-Adrenal Axis Pathology in 1-Month-Abstinent Alcohol-Dependent Men, Part 2: Response to Ovine Corticotropin-Releasing Factor and Naloxone

dc.contributor.authorAdinoff, Bryonen_US
dc.contributor.authorKrebaum, Steven R.en_US
dc.contributor.authorChandler, Patricia A.en_US
dc.contributor.authorYe, Wenen_US
dc.contributor.authorBrown, Morton B.en_US
dc.contributor.authorWilliams, Mark J.en_US
dc.date.accessioned2010-04-01T14:43:45Z
dc.date.available2010-04-01T14:43:45Z
dc.date.issued2005-04en_US
dc.identifier.citationAdinoff, Bryon; Krebaum, Steven R.; Chandler, Patricia A.; Ye, Wen; Brown, Morton B.; Williams, Mark J. (2005). "Dissection of Hypothalamic-Pituitary-Adrenal Axis Pathology in 1-Month-Abstinent Alcohol-Dependent Men, Part 2: Response to Ovine Corticotropin-Releasing Factor and Naloxone." Alcoholism: Clinical and Experimental Research 29(4): 528-537. <http://hdl.handle.net/2027.42/65174>en_US
dc.identifier.issn0145-6008en_US
dc.identifier.issn1530-0277en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65174
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15834217&dopt=citationen_US
dc.description.abstractPituitary and adrenal responsiveness is suppressed in abstinent alcohol-dependent individuals. To clarify the specific organizational disruption in hypothalamic-pituitary-adrenal functioning during early abstinence, the authors separately assessed each level of the stress-response axis. In this second of a two-part study, ovine corticotropin-releasing factor (oCRH) was used to stimulate the pituitary corticotrophs, and naloxone was used to activate the axis at the hypothalamic level. In addition, pulsatile characteristics of corticotropin and cortisol were assessed over a 12-hr period (0800 to 2000 hr). Methods : Eleven abstinent alcohol-dependent men and 10 healthy comparison participants were assessed. All participants were between the ages of 30 and 50 years, and alcohol-dependent patients were abstinent from 4 to 6 weeks. Basal concentrations of corticotropin and cortisol were obtained every 10 min from 0800 to 2000 hr and subjected to pulsatile analysis. Plasma corticotropin and cortisol concentrations were then obtained every 5 to 10 min after low-dose, intravenously administered doses of oCRH (0.4 μg/kg) or naloxone (0.125 mg/kg). Medications were administered at 2000 hr and the two challenge studies were separated by 48 hr. Results : Pulsatile analysis revealed that the mean corticotropin amplitude was increased in alcohol-dependent patients relative to controls ( p < 0.05). Other pulsatile characteristics of corticotropin and all cortisol pulsatile measures were not significantly different between the two groups. The integrated cortisol response to oCRH was significantly lower in alcohol-dependent patients compared with controls ( p < 0.01), but the integrated corticotropin response was not significantly different. In contrast, neither the corticotropin nor the cortisol response to naloxone was significantly different between groups. Conclusions : Adrenocorticoid hyposensitivity persists after oCRH infusion for at least 1 month after cessation of drinking, whereas hyporesponsiveness of the pituitary corticotrophs to CRH seems to resolve with continued abstinence. The authors suggest that adrenocortical hyporesponsiveness during prolonged abstinence may impact relapse risk.en_US
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dc.format.extent3110 bytes
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dc.publisherBlackwell Publishing Ltden_US
dc.rights2005 The Research Society on Alcoholismen_US
dc.titleDissection of Hypothalamic-Pituitary-Adrenal Axis Pathology in 1-Month-Abstinent Alcohol-Dependent Men, Part 2: Response to Ovine Corticotropin-Releasing Factor and Naloxoneen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas (BA, SRK, MJW); the Veterans Affairs North Texas Health Care System, Dallas, Texas (BA); PrimaCare Medical Center, Dallas, Texas (PAC); and the Department of Biostatistics, University of Michigan, Ann Arbor, Michigan (WY, MBB).en_US
dc.identifier.pmid15834217en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65174/1/01.ALC.0000158939.25531.EE.pdf
dc.identifier.doi10.1097/01.ALC.0000158939.25531.EEen_US
dc.identifier.sourceAlcoholism: Clinical and Experimental Researchen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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