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Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance
dc.contributor.authorFisher, Stephen K.en_US
dc.contributor.authorNovak, James E.en_US
dc.contributor.authorAgranoff, Bernard W.en_US
dc.date.accessioned2010-04-01T14:45:16Z
dc.date.available2010-04-01T14:45:16Z
dc.date.issued2002-08en_US
dc.identifier.citationFisher, Stephen K.; Novak, James E.; Agranoff, Bernard W. (2002). "Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance." Journal of Neurochemistry 82(4): 736-754. <http://hdl.handle.net/2027.42/65201>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65201
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12358779&dopt=citationen_US
dc.description.abstractInositol phospholipids and inositol phosphates mediate well-established functions in signal transduction and in Ca 2+ homeostasis in the CNS and non-neural tissues. More recently, there has been renewed interest in other roles that both myo -inositol and its highly phosphorylated forms may play in neural function. We review evidence that myo -inositol serves as a clinically relevant osmolyte in the CNS, and that its hexakisphosphate and pyrophosphorylated derivatives may play roles in such diverse cellular functions as DNA repair, nuclear RNA export and synaptic membrane trafficking.en_US
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dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Science Ltden_US
dc.rights2002 International Society for Neurochemistryen_US
dc.subject.otherAffective Disorder and Treatmenten_US
dc.subject.otherDiphosphoinositol Polyphosphatesen_US
dc.subject.otherInositol Hexakisphosphateen_US
dc.subject.otherLithiumen_US
dc.subject.otherNa +en_US
dc.subject.otherMyo-inositol Transporteren_US
dc.subject.otherPhytateen_US
dc.titleInositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significanceen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum† Biochemistry and Psychiatry, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationother* Mental Health Research Institute, and Departments ofen_US
dc.contributor.affiliationother† Pharmacology, anden_US
dc.identifier.pmid12358779en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65201/1/j.1471-4159.2002.01041.x.pdf
dc.identifier.doi10.1046/j.1471-4159.2002.01041.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
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