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Activation of muscarinic cholinergic receptors enhances the volume-sensitive efflux of myo-inositol from SH-SY5Y neuroblastoma cells
dc.contributor.authorLoveday, Dannyen_US
dc.contributor.authorHeacock, Anne M.en_US
dc.contributor.authorFisher, Stephen K.en_US
dc.date.accessioned2010-04-01T14:47:33Z
dc.date.available2010-04-01T14:47:33Z
dc.date.issued2003-10en_US
dc.identifier.citationLoveday, Danny; Heacock, Anne M.; Fisher, Stephen K. (2003). "Activation of muscarinic cholinergic receptors enhances the volume-sensitive efflux of myo-inositol from SH-SY5Y neuroblastoma cells." Journal of Neurochemistry 87(2): 476-486. <http://hdl.handle.net/2027.42/65241>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65241
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14511125&dopt=citationen_US
dc.description.abstractA mechanism used by cells to regulate their volume under hypo-osmotic conditions is the release of organic osmolytes, one of which is myo-inositol. The possibility that activation of phospholipase-C-linked receptors can regulate this process has been examined for SH-SY5Y neuroblastoma cells. Incubation of cells with hypo-osmolar buffers (160–250 mOsm) led to a biphasic release of inositol which persisted for up to 4 h and could be inhibited by inclusion of anion channel blockers – results which indicate the involvement of a volume-sensitive organic anion channel. Inclusion of oxotremorine-M, a muscarinic cholinergic agonist, resulted in a marked increase (80–100%) in inositol efflux under hypo-osmotic, but not isotonic, conditions. This enhanced release, which was observed under all conditions of hypo-osmolarity tested, could be prevented by inclusion of atropine. Incubation of the cells with either the calcium ionophore, ionomycin, or the phorbol ester, phorbol 12-myristate 13-acetate, partially mimicked the stimulatory effect of muscarinic receptor activation when added singly, and fully when added together. The ability of oxotremorine-M to facilitate inositol release was inhibited by removal of extracellular calcium, depletion of intracellular calcium or down-regulation of protein kinase C. These results indicate that activation of muscarinic cholinergic receptors can regulate osmolyte release in this cell line.en_US
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dc.format.extent3110 bytes
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dc.publisherBlackwell Science Ltden_US
dc.rights2003 International Society for Neurochemistryen_US
dc.subject.otherCalciumen_US
dc.subject.otherMuscarinic Cholinergic Receptorsen_US
dc.subject.otherMyo-inositolen_US
dc.subject.otherOsmolyteen_US
dc.subject.otherProtein Kinase Cen_US
dc.subject.otherVolume Regulationen_US
dc.titleActivation of muscarinic cholinergic receptors enhances the volume-sensitive efflux of myo-inositol from SH-SY5Y neuroblastoma cellsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum† Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationother* Mental Health Research Instituteen_US
dc.identifier.pmid14511125en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65241/1/j.1471-4159.2003.02021.x.pdf
dc.identifier.doi10.1046/j.1471-4159.2003.02021.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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