Lead exposure and periodontitis in US adults
dc.contributor.author | Saraiva, M. C. P. | en_US |
dc.contributor.author | Taichman, Russell S. | en_US |
dc.contributor.author | Braun, T. | en_US |
dc.contributor.author | Nriagu, Jerome O. | en_US |
dc.contributor.author | Eklund, Stephen A. | en_US |
dc.contributor.author | Burt, Brian A. | en_US |
dc.date.accessioned | 2010-04-01T14:48:13Z | |
dc.date.available | 2010-04-01T14:48:13Z | |
dc.date.issued | 2007-02 | en_US |
dc.identifier.citation | Saraiva, M. C. P.; Taichman, R. S.; Braun, T.; Nriagu, J.; Eklund, S. A.; Burt, B. A. (2007). "Lead exposure and periodontitis in US adults." Journal of Periodontal Research 42(1): 45-52. <http://hdl.handle.net/2027.42/65253> | en_US |
dc.identifier.issn | 0022-3484 | en_US |
dc.identifier.issn | 1600-0765 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/65253 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17214639&dopt=citation | en_US |
dc.description.abstract | Lead is known to have significant effects on bone metabolism and the immune system. This study tested the hypothesis that lead exposure affects periodontitis in adults. Material and Methods: This study used the data from the Third National Health and Nutrition Examination Survey (NHANES III, 1988–94). It analyzed data from 2500 men and 2399 women, 20–56 yr old, who received complete periodontal examination. Periodontitis was defined as the presence of > 20% of mesial sites with ≥ 4 mm of attachment loss. Lead exposure was grouped into three categories: < 3; 3–7; and > 7 μg/dL. Covariates were cotinine levels, poverty ratio, race/ethnicity, education, bone mineral density, diabetes, calcium intake, dental visit, and menopause (for women). All analyses were performed separately for men and women and considering the effect design. Univariate, bivariate, and stratified analysis was followed by multivariable analysis by estimating prevalence ratios through poisson regression. Results: After adjustment for confounders, the prevalence ratios, comparing those with a lead blood level of > 7 μg/dL to those with a lead blood level of < 3 μg/dL was 1.70 (95% confidence interval (CI): 1.02, 2.85) for men and 3.80 (95% CI: 1.66, 8.73) for women. Conclusion: The lead blood level was positively and statistically associated with periodontitis for both men and women. Considering the public health importance of periodontitis and lead exposure, further studies are necessary to confirm this association. | en_US |
dc.format.extent | 503056 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 2007 The Authors. Journal compilation 2007 Blackwell Munksgaard | en_US |
dc.subject.other | Adults | en_US |
dc.subject.other | Lead Exposure | en_US |
dc.subject.other | Oral Health | en_US |
dc.subject.other | Periodontitis | en_US |
dc.subject.other | Toxicology | en_US |
dc.title | Lead exposure and periodontitis in US adults | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Periodontics and Oral Medicine, Prevention, Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Paediatrics and Social Dentistry, School of Dentistry of RibeirÃo Preto, University of SÃo Paulo, SP, Brazil | en_US |
dc.contributor.affiliationother | Biostatistics | en_US |
dc.contributor.affiliationother | Environmental Health Science | en_US |
dc.identifier.pmid | 17214639 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/65253/1/j.1600-0765.2006.00913.x.pdf | |
dc.identifier.doi | 10.1111/j.1600-0765.2006.00913.x | en_US |
dc.identifier.source | Journal of Periodontal Research | en_US |
dc.identifier.citedreference | Elreedy S, Krieger N, Ryan P, Sparrow D, Weiss ST, Hu H. Relations between individual and neighborhood-based measures of socioeconomic position and bone lead concentrations among community-exposed men. Am J Epidemiol 1999 ; 150 : 129 – 141. | en_US |
dc.identifier.citedreference | Pirkle JL, Brody DJ, Gunter EW et al. The decline in the blood lead levels in the United States. The National health and Nutritional Examination Surveys (NHANES). J Am Med Assoc 1994 ; 272 : 284 – 291. | en_US |
dc.identifier.citedreference | Payton M, Hu H, Sparrow D, Weiss ST. Low-level lead exposure and renal function in the Normative Aging Study. Am J Epidemiol 1994 ; 140 : 821 – 829. | en_US |
dc.identifier.citedreference | Cheng Y, Schwartz J, Sparrow D, Aro A, Weiss ST, Hu H. Bone lead and blood lead levels in relation to baseline blood pressure and the prospective development of hypertension. Am J Epidemiol 2001 ; 153 : 164 – 171. | en_US |
dc.identifier.citedreference | Pounds JG, Long GJ, Rosen JF. Cellular and molecular toxicity of lead in bone. Environ Health Perspect 1991 ; 91 : 17 – 32. | en_US |
dc.identifier.citedreference | Silbergeld EK, Sauk J, Sommerman M et al. Lead in bone: storage site, exposure source, target organ. Neurotoxicology 1993 ; 14 : 225 – 236. | en_US |
dc.identifier.citedreference | Pinkerton LE, Biagini RE, Ward EM et al. Immunologic findings among lead-exposed workers. Am J Ind Med 1998 ; 33 : 400 – 408. | en_US |
dc.identifier.citedreference | Pineda-Zavaleta AP, Garcia-Vargas G, Borja-Aburto VH et al. Nitric oxide and superoxide anion production in monocytes from children exposed to arsenic and lead in region Lagunera, Mexico. Toxicol Appl Pharmacol 2004 ; 198 : 283 – 290. | en_US |
dc.identifier.citedreference | Offenbacher S. Periodontal diseases: pathogenesis. Ann Periodontol 1996 ; 1 : 821 – 878. | en_US |
dc.identifier.citedreference | Mundy GR, Guise TA. Hormonal control of calcium homeostasis. Clin Chem 1999 ; 45 : 1347 – 1352. | en_US |
dc.identifier.citedreference | Sauk JJ, Smith T, Silbergeld EK, Fowler B, Sommerman M. Lead inhibits secretion of osteonectin/SPARC without significantly altering collagen or Hsp47 production on osteoblast like ROS 17/2.8 cells. Toxicol Appl Pharmacol 1992 ; 116 : 240 – 247. | en_US |
dc.identifier.citedreference | Goldberg RL, Kaplan SR, Fuller GC. Effect of heavy metals on human rheumatoid synovial cell proliferation and collagen synthesis. Biochem Pharmacol 1983 ; 32 : 2763 – 2766. | en_US |
dc.identifier.citedreference | Dowd TL, Rosen JF, Gundberg CM, Gupta RK. The displacement of calcium from osteocalcin at submicromolar concentrations of free lead. Biochem Biophys Acta 1994 ; 1226 : 131 – 137. | en_US |
dc.identifier.citedreference | Miyahara T, Komiyama H, Miyanishi A et al. Stimulative effects of lead on bone resorption in organ culture. Toxicology 1995 ; 97 : 191 – 197. | en_US |
dc.identifier.citedreference | Lee JJ, Battles AH. Lead toxicity via arachidonate signal transduction to growth responses in the splenic macrophage. Environ Res 1994 ; 67 : 209 – 219. | en_US |
dc.identifier.citedreference | Koo W, Succop PA, Bornschein RL et al. Serum vitamin D metabolites and bone mineralization in young children with chronic low to moderate lead exposure. Pediatrics 1991 ; 87 : 680 – 687. | en_US |
dc.identifier.citedreference | Kim RHH, Rotnitzzky A, Bellinger DC, Needleman HL. A longitudinal study of chronic lead exposure and physical growth in Boston children. Environ Health Perspect 1995 ; 103 : 952 – 957. | en_US |
dc.identifier.citedreference | Schwartz J, Angle C, Pitcher H. Relationship between childhood blood lead levels and stature. Pediatrics 1986 ; 77 : 281 – 288. | en_US |
dc.identifier.citedreference | Gruber HH, Gonickm HC, Khalil-Manesh F et al. Ostepenia induced by long term, low- and high-level exposure of the adult rat to lead. Miner Electrolyte Metab 1997 ; 23 : 65 – 73. | en_US |
dc.identifier.citedreference | Gruber HH, Ding Y, Stasky AA et al. Adequate dietary calcium mitigates osteopenia induced by chronic lead exposure in adult rats. Miner Electrolyte Metab 1999 ; 25 : 143 – 146. | en_US |
dc.identifier.citedreference | Hemphill F, Kaeberle MWB. Lead suppression of mouse resistance to Salmonella typhimurium. Science 1971 ; 172 : 1031 – 1032. | en_US |
dc.identifier.citedreference | McCabe MJ Jr, Lawrence DA. Lead, a major environmental pollutant, is immunomodulatory by its differential effects on CD4+ T cell subsets. Toxicol Appl Pharmacol 1991 ; 111 : 13 – 23. | en_US |
dc.identifier.citedreference | Dentener MA, Greve JW, Maessen JG, Buurman WA. Role of tummor necrosis factor in the enhanced sensitivity of mice to endotoxin after exposure to lead. Immunopharmacol Immunotoxicol 1989 ; 11 : 321 – 334. | en_US |
dc.identifier.citedreference | Kishikawa H, Song R, Lawrence DA. Interleukin-12 promotes enhanced resistance to Listeria monocytogenes infection of lead-exposed mice. Toxicol Appl Pharmacol 1997 ; 147 : 180 – 189. | en_US |
dc.identifier.citedreference | Fishchein A, Tsang P, Luo JC, Roboz JP, Jiang JD, Bekesi JG. Phenotypic aberrations of CD3+ and CD4+ cells and functional impairments of lymphocytes at low-level occupational exposure to lead. Clin Immunol Immunopathol 1993 ; 66 : 163 – 168. | en_US |
dc.identifier.citedreference | Underger U, Basaran N, Campinar H, Kansu E. Immune alterations in lead-exposed workers. Toxicology 1996 ; 109 : 167 – 172. | en_US |
dc.identifier.citedreference | Queiroz ML, Almeida M, Gallao MI, Hoehr NF. Defective neutrophil function in workers occupationally exposed to lead. Pharmacol Toxicol 1993 ; 72 : 73 – 77. | en_US |
dc.identifier.citedreference | Queiroz ML, Perlingeiro RC, Almeida M, Bincoletto C, Cardoso MP, Daniel DC. Immunoglobulin levels and cellular immune function in lead exposed workers. Immunopharmacol Immunotoxicol 1994 ; 16 : 115 – 128. | en_US |
dc.identifier.citedreference | Daniel D, Van Dyke TE. Alterations in phagocyte function and periodontal infection. J Periodontol 1996 ; 67 : 1070 – 1075. | en_US |
dc.identifier.citedreference | Wactawski-Wende J, Grossi SG, Trevisan M, Tezal M, Genco RJ. The role of osteopenia on oral bone loss and periodontal disease. J Periodontol 1996 ; 67 : 1076 – 1084. | en_US |
dc.identifier.citedreference | Yamamoto M, Fujihashi K, McGee JR, Van Dyke TE, Kiyono H. Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. J Periodont Res 1997 ; 32 : 115 – 119. | en_US |
dc.identifier.citedreference | Carmouche JJ, Puzas JE, Zhang X et al. Lead exposure inhibitis fracture healing and is associated with increased chodrogenesis, delay in cartilage mineralization, and decrease in osteoprogenitor frequency. Environ Health Perspect 2005 ; 113 : 749 – 755. | en_US |
dc.identifier.citedreference | Baranska-Gachowska M, Postek L, Soja J. [The effect of an environment contaminated with lead and cadmium compounds on the condition of teeth in schoolchildren in Zyglin and Pniowiec]. Cza Stomatol 1987 ; 40 : 158 – 165. | en_US |
dc.identifier.citedreference | Stawinski K, Szponar E, Orkiszewa M. Diseases of periodontium and oral mucosa in workers exposed to various harmful working environmental factors. Cza Stomatol 1987 ; 40 : 137 – 141. | en_US |
dc.identifier.citedreference | Dye BA, Hirsch R, Brody DJ. The relationship between blood lead levels and periodontal bone loss in the United States. Environ Health Perspect 2002 ; 110 : 997 – 1002. | en_US |
dc.identifier.citedreference | Nash D, Magder LS, Sherwin R, Rubin RJ, Silbergeld EK. Bone density-related predictors of blood lead level among peri- and postmenopausal women in the United States. The Third National Health Nutrition Examination Survey, 1988–1994. Am J Epidemiol 2004 ; 160 : 901 – 911. | en_US |
dc.identifier.citedreference | Nishida M, Grossi SG, Dunford RG, Ho AW, Trevisan M, Genco RJ. Calcium and the risk for periodontal disease. J Periodontol 2000 ; 71 : 1057 – 1066. | en_US |
dc.identifier.citedreference | 38. National Center for Health Statistics CfDCaP. Analytic and reporting guidelines: The Third National Health and Nutrition Examination Survey, NHANES III (1988–94). Hyattsville, MD : Center for Disease Control and Prevention, 1996. | en_US |
dc.identifier.citedreference | 39. National Health for Statistics. National Health and Nutrition Examination Survey III. Oral Examination Component. Hyattsville, MD : Center for Disease Control and Prevention, 1992. | en_US |
dc.identifier.citedreference | Slade GD, Offenbacher S, Beck JD, Heiss G, Pankow JS. Acute-phase inflammatory response to periodontal disease in US population. J Dent Res 2000 ; 79 : 49 – 57. | en_US |
dc.identifier.citedreference | 41. US Department of Health and Human Services (DHSS) National Center for Health Statistics. NHANES III reference manual and reports (CD-ROM). Hyattsville : Center for Disease Control and Prevention, 1997. | en_US |
dc.identifier.citedreference | 42. World Health Organization. Assessment of Fracture Risk and its Applications to Screen for Postmenopausal Osteoporosis. Geneva : World Health Organization, 1994. | en_US |
dc.identifier.citedreference | Nordin BEC, Wishart JM, Clifton PM, McArthur R, Morris HA, O'Loughlin PD. A longitudinal study of bone-related biochemical changes at the menopause. Clin Endocrinol 2004 ; 61 : 123 – 130. | en_US |
dc.identifier.citedreference | Akesson A, Vahter M, Berglund M, Eklof T, Bremme K, Bjellerup P. Bone turnover from early pregnancy to postweaning. Acta Obstet Gynecol Scand 2004 ; 3 : 1049 – 1055. | en_US |
dc.identifier.citedreference | Barros AJ, Hirakata VN. Alternatives for logistic regression in cross-sectional studies: empirical comparison of models that directly estimate the prevalence ratio. BMC Med Res Methodol 2003 ; 20 : 21. | en_US |
dc.identifier.citedreference | Pirkle JL, Kaufmann RB, Brody DJ, Hickman T, Gunter EW, Paschal DC. Exposure of the US population to lead, 1991–94. Environ Health Perspect 1998 ; 106 : 745 – 750. | en_US |
dc.identifier.citedreference | 47. US. Department of Health & Human Services PHS AfTSaDR. Toxicological Profile for Lead. Atlanta : Agency for Toxic Substance and Disease Registry, 1999 | en_US |
dc.identifier.citedreference | Hu H, Payton M, Korrick S, Sparrow D, Weiss ST, Rotnitzzky A. Determinants of bone and blood lead levels among community-exposed middle-aged to elderly men. The normative aging study. Am J Epidemiol 1996 ; 144 : 479 – 459. | en_US |
dc.identifier.citedreference | Krieger N, Williams DR, Moss NE. Measuring social class in US public health research: concepts, methodologies and guidelines. Annu Rev Public Health 1997 ; 18 : 341 – 378. | en_US |
dc.identifier.citedreference | Yen IH, Kaplan GA. Neighborhood social environment and risk of death: multilevel evidence from Alameda County. Am J Epidemiol 1999 ; 149 : 898 – 907. | en_US |
dc.identifier.citedreference | Lang WP, Ronis DL, Farghaly MM. Preventive behaviors as correlates to periodontal health. J Public Health Dent 1995 ; 55 : 10 – 17. | en_US |
dc.identifier.citedreference | Locker D, Jacovic A, Payne B. Life circumstances, lifestyles and oral health among older Canadians. Community Dental Health 1997 ; 14 : 214 – 220. | en_US |
dc.identifier.citedreference | Rautio N, Adamson J, Heikkinen E, Ebrahim S. Associations of socio-economic position and disability among older woman in Britain and Jyvaskyla, Finland. Arch Gerontol Geriatr 2006 ; 42 : 141 – 145. | en_US |
dc.identifier.citedreference | Dugmore CR, Rock WP. The effect of socio-economic status and ethnicity on the comparative oral health of Asian and White Caucasian 12-year-old children. Community Dent Health 2005 ; 22 : 162 – 169. | en_US |
dc.identifier.citedreference | Cheng Y, Willet WC, Schwartz J. Relation of nutrition to bone lead and blood lead levels in middle-aged to elderly men: the normative aging study. Am J Epidemiol 1998 ; 147 : 1162 – 1174. | en_US |
dc.identifier.citedreference | Mahaffey KR. Environment lead toxicity: nutrition as component of intervention. Environ Health Perspect 1990 ; 89 : 75 – 78. | en_US |
dc.identifier.citedreference | Spiekerman CF, Hujoel PP, De Roen TA. Bias induced by self-reported smoking on periodontitis–systemic disease associations. J Dent Res 2003 ; 82 : 345 – 349. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.