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A New Paradigm for Clinical Investigation of Infectious Syndromes in Older Adults: Assessing Functional Status as a Risk Factor and Outcome Measure
dc.contributor.authorHigh, Kevin P.en_US
dc.contributor.authorBradley, Suzanneen_US
dc.contributor.authorLoeb, Marken_US
dc.contributor.authorPalmer, Roberten_US
dc.contributor.authorQuagliarello, Vincent J.en_US
dc.contributor.authorYoshikawa, Thomas T.en_US
dc.date.accessioned2010-04-01T14:49:41Z
dc.date.available2010-04-01T14:49:41Z
dc.date.issued2005-03en_US
dc.identifier.citationHigh, Kevin; Bradley, Suzanne; Loeb, Mark; Palmer, Robert; Quagliarello, Vincent; Yoshikawa, Thomas (2005). "A New Paradigm for Clinical Investigation of Infectious Syndromes in Older Adults: Assessing Functional Status as a Risk Factor and Outcome Measure." Journal of the American Geriatrics Society 53(3): 528-535. <http://hdl.handle.net/2027.42/65279>en_US
dc.identifier.issn0002-8614en_US
dc.identifier.issn1532-5415en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65279
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15743301&dopt=citationen_US
dc.description.abstractAdults aged 65 and over comprise the fastest growing segment of the U.S. population, and older adults experience greater morbidity and mortality due to infection than young adults. While this factor is well established, most clinical investigation of infectious diseases in the aged focuses on microbiology, and crude endpoints of clinical success such as cure rates or mortality, but often fails to assess functional status, a critical variable in geriatric care. Functional status can be evaluated as a risk factor for infectious disease or an outcome of interest following specific interventions utilizing well-validated instruments. This paper outlines the currently available data suggesting a link between infection, immunity and impaired functional status in the elderly, summarizes commonly employed instruments used to determine specific aspects of functional status, and provides recommendations for a new paradigm in which clinical trials of older adults include functional assessment.en_US
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dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Science Incen_US
dc.rights© 2005 by the American Geriatrics Societyen_US
dc.subject.otherAgingen_US
dc.subject.otherFunctional Assessmenten_US
dc.subject.otherInfectionen_US
dc.subject.otherClinical Researchen_US
dc.titleA New Paradigm for Clinical Investigation of Infectious Syndromes in Older Adults: Assessing Functional Status as a Risk Factor and Outcome Measureen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeriatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumVA Medical Center, Department of Internal Medicine, Division of Infectious Diseases, University of Michigan School of Medicine, Ann Arbor, MIen_US
dc.contributor.affiliationotherDepartment of Internal Medicine, Sections of Infectious Diseases and Hematology/Oncology, Wake Forest University Health Sciences, Winston Salem, NCen_US
dc.contributor.affiliationotherDivision of Infectious Diseases and Medical Microbiology, McMaster University and Hamilton Civic Hospitals, Hamilton, Ontario, Canadaen_US
dc.contributor.affiliationotherSection of Geriatric Medicine, Cleveland Clinic Foundation, Cleveland, OHen_US
dc.contributor.affiliationotherDepartment of Internal Medicine, Infectious Diseases Section, Yale University School of Medicine, New Haven, CTen_US
dc.contributor.affiliationotherDepartment of Internal Medicine, Charles R. Drew University of Medicine and Science, King-Drew Medical Center, Los Angeles, CA.en_US
dc.identifier.pmid15743301en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65279/1/j.1532-5415.2005.53240.x.pdf
dc.identifier.doi10.1111/j.1532-5415.2005.53240.xen_US
dc.identifier.sourceJournal of the American Geriatrics Societyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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