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Muscarinic Receptors in Chromaffin Cell Cultures Mediate Enhanced Phospholipid Labeling but Not Catecholamine Secretion
dc.contributor.authorFisher, Stephen K.en_US
dc.contributor.authorHolz, Ronald W.en_US
dc.contributor.authorAgranoff, Bernard W.en_US
dc.date.accessioned2010-04-01T14:50:26Z
dc.date.available2010-04-01T14:50:26Z
dc.date.issued1981-08en_US
dc.identifier.citationFisher, Stephen K.; Holz, Ronald W.; Agranoff, Bernard W. (1981). "Muscarinic Receptors in Chromaffin Cell Cultures Mediate Enhanced Phospholipid Labeling but Not Catecholamine Secretion." Journal of Neurochemistry 37(2): 491-497. <http://hdl.handle.net/2027.42/65292>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65292
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7264672&dopt=citationen_US
dc.description.abstractThe addition of either carbachol or muscarinic agonists to cultured bovine adrenal chromaffin cells results in a selective stimulation of phosphatidate (PhA) and phosphatidylinositol (PhI) labeling from 32 P i and [ 3 H]glycerol that can be inhibited by the inclusion of atropine, but not d -tubocurarine. In contrast, increased catecholamine secretion is observed on the addition of carbachol or nicotinic agonists and is inhibited by d -tubocurarine but not by atropine. Added calcium is essential for catecholamine secretion but not for stimulated phospholipid labeling. Chelation of endogenous Ca 2+ with EGTA does, however, inhibit the stimulated phospholipid labeling. These results suggest that stimulated phospholipid labeling in the bovine chromaffin cell and catecholamine secretion are separate and distinct processes.en_US
dc.format.extent613995 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1981 International Society for Neurochemistry Ltd.en_US
dc.subject.otherCholinergic Agonisten_US
dc.subject.otherMuscarinic Receptoren_US
dc.subject.otherBovine Adrenal Chromaffin Cellen_US
dc.subject.otherPhosphatidateen_US
dc.subject.otherPhosphatidylinositolen_US
dc.titleMuscarinic Receptors in Chromaffin Cell Cultures Mediate Enhanced Phospholipid Labeling but Not Catecholamine Secretionen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum* Neuroscience Laboratory, Mental Health Research Institute, and Department of Biological Chemistry, University of Michiganen_US
dc.contributor.affiliationum† Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, U.S.A.en_US
dc.identifier.pmid7264672en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65292/1/j.1471-4159.1981.tb00482.x.pdf
dc.identifier.doi10.1111/j.1471-4159.1981.tb00482.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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