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Formation of Free Fatty Acid and Ceramide During Brain Handling: Lability of Sphingomyelin

dc.contributor.authorDeshmukh, Gayatri D.en_US
dc.contributor.authorRadin, Norman S.en_US
dc.date.accessioned2010-04-01T14:50:39Z
dc.date.available2010-04-01T14:50:39Z
dc.date.issued1985-04en_US
dc.identifier.citationDeshmukh, Gayatri D.; Radin, Norman S. (1985). "Formation of Free Fatty Acid and Ceramide During Brain Handling: Lability of Sphingomyelin." Journal of Neurochemistry 44(4): 1152-1155. <http://hdl.handle.net/2027.42/65296>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65296
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2983027&dopt=citationen_US
dc.description.abstractIntact brain and brain homogenates readily form free fatty acids and ceramides, even in the cold during subcellular isolation procedures. The fatty acid formation is slightly stimulated by chelators and might be due to phospholipid hydrolysis by lysosomal phospholipases. The ceramide formation is accompanied by loss of sphingomyelin and is apparently due to the action of neutral, metal ion-activated sphingomyelinase. The latter reaction is inhibited by EDTA whereas both degradative processes are inhibited by mercuriphenylsulfonate, the thiol-reacting inhibitor. Cerebroside does not seem to be a source of accumulated ceramide.en_US
dc.format.extent405640 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1985 International Society for Neurochemistryen_US
dc.subject.otherSphin Gomyelinaseen_US
dc.subject.otherGalactocerebrosidaseen_US
dc.subject.otherCeramide Formationen_US
dc.subject.otherFree Fatty Acid Formationen_US
dc.titleFormation of Free Fatty Acid and Ceramide During Brain Handling: Lability of Sphingomyelinen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute and Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan, U.S.Aen_US
dc.identifier.pmid2983027en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65296/1/j.1471-4159.1985.tb08737.x.pdf
dc.identifier.doi10.1111/j.1471-4159.1985.tb08737.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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