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Inositol Trisphosphate Mobilizes Intracellular Calcium in Permeabilized Adrenal Chromaffin Cells
dc.contributor.authorStoehr, Sally Joen_US
dc.contributor.authorSmolen, James E.en_US
dc.contributor.authorHolz, Ronald W.en_US
dc.contributor.authorAgranoff, Bernard W.en_US
dc.date.accessioned2010-04-01T14:51:14Z
dc.date.available2010-04-01T14:51:14Z
dc.date.issued1986-02en_US
dc.identifier.citationStoehr, Sally J.; Smolen, James E.; Holz, Ronald W.; Agranoff, Bernard W. (1986). "Inositol Trisphosphate Mobilizes Intracellular Calcium in Permeabilized Adrenal Chromaffin Cells." Journal of Neurochemistry 46(2): 637-640. <http://hdl.handle.net/2027.42/65306>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65306
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3484517&dopt=citationen_US
dc.description.abstractUsing permeabilized chromaffin cells and the fluorescent probe Quin 2 (an indicator of free Ca 2+ ), we found that inositol trisphosphate (IP 3 ) specifically triggered an immediate and dose-dependent release of Ca 2+ from intracellular stores. Desensitization of the response was observed at nonsaturating concentrations of inositol trisphosphate and resequestration of Ca 2+ was not observed. While representing only a small fraction of the total cellular Ca 2+ , the amount released by IP 3 could significantly raise cytosolic Ca 2+ and may account for muscarinic effects on Ca 2+ metabolism in chromaffin cells.en_US
dc.format.extent368375 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1986 International Society for Neurochemistryen_US
dc.subject.otherInositol Trisphosphateen_US
dc.subject.otherIntracellular Calciumen_US
dc.subject.otherChromaffin Cellsen_US
dc.subject.otherQuin 2en_US
dc.titleInositol Trisphosphate Mobilizes Intracellular Calcium in Permeabilized Adrenal Chromaffin Cellsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.contributor.affiliationum* Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.contributor.affiliationum† Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.identifier.pmid3484517en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65306/1/j.1471-4159.1986.tb13014.x.pdf
dc.identifier.doi10.1111/j.1471-4159.1986.tb13014.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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