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Activity-Dependent Regulation of Na + ,K + -ATPase Α Isoform mRNA Expression In Vivo
dc.contributor.authorMata, Marinaen_US
dc.contributor.authorHieber, Virginia C.en_US
dc.contributor.authorBeaty, Michael W.en_US
dc.contributor.authorClevenger, Michaelen_US
dc.contributor.authorFink, David J.en_US
dc.date.accessioned2010-04-01T14:55:52Z
dc.date.available2010-04-01T14:55:52Z
dc.date.issued1992-08en_US
dc.identifier.citationMata, Marina; Hieber, Virginia; Beaty, Michael; Clevenger, Michael; Fink, David J. (1992). "Activity-Dependent Regulation of Na + ,K + -ATPase Α Isoform mRNA Expression In Vivo." Journal of Neurochemistry 59(2): 622-626. <http://hdl.handle.net/2027.42/65388>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65388
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1321232&dopt=citationen_US
dc.description.abstractTo investigate the functional role of the different Na + ,K + -ATPase a (catalytic) subunit isoforms in neuronal cells, we used quantitative in situ hybridization with riboprobes specific for Αl, Α2, and Α3 isoforms to measure the level of a isoform-specific expression in the neuroendocrine cells of the supraoptic (SON) and paraventricular (PVN) nuclei of rat hypothalamus. A prolonged increase in electrical activity of these cells, achieved by 5 days of salt treatment, increased the amount of Α isoform mRNA in the SON and PVN by 50%. Levels of Α mRNA in other brain regions and levels of Α2 and Α3 mRNAs were not affected by salt treatment. We conclude that the Α1 isoform Na + ,K + -ATPase may be specifically adapted to pump out Na + , which enters the cells through voltage-gated channels during neuronal depolarization.en_US
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dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1992 International Society for Neurochemistryen_US
dc.subject.otherNa + ,K + -ATP-aseen_US
dc.subject.otherMRNAen_US
dc.subject.otherIsoformen_US
dc.subject.otherCNSen_US
dc.titleActivity-Dependent Regulation of Na + ,K + -ATPase Α Isoform mRNA Expression In Vivoen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan; and GRECC, V. A. Medical Center, Ann Arbor, Michigan, U.S.A.en_US
dc.identifier.pmid1321232en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65388/1/j.1471-4159.1992.tb09415.x.pdf
dc.identifier.doi10.1111/j.1471-4159.1992.tb09415.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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