Cellular Bases of Barbiturate and Phenytoin Anticonvulsant Drug Action
dc.contributor.author | Macdonald, Robert L. | en_US |
dc.contributor.author | McLean, Michael J. | en_US |
dc.date.accessioned | 2010-04-01T15:02:50Z | |
dc.date.available | 2010-04-01T15:02:50Z | |
dc.date.issued | 1982-12 | en_US |
dc.identifier.citation | Macdonald, Robert L.; McLean, Michael J. (1982). "Cellular Bases of Barbiturate and Phenytoin Anticonvulsant Drug Action." Epilepsia 23(): S7-S18. <http://hdl.handle.net/2027.42/65509> | en_US |
dc.identifier.issn | 0013-9580 | en_US |
dc.identifier.issn | 1528-1167 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/65509 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7140671&dopt=citation | en_US |
dc.format.extent | 785545 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1982 International League Against Epilepsy | en_US |
dc.title | Cellular Bases of Barbiturate and Phenytoin Anticonvulsant Drug Action | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 7140671 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/65509/1/j.1528-1157.1982.tb06093.x.pdf | |
dc.identifier.doi | 10.1111/j.1528-1157.1982.tb06093.x | en_US |
dc.identifier.source | Epilepsia | en_US |
dc.identifier.citedreference | Nelson PG., Neale EA., Macdonald RL. Electrophysiological and structural studies of neurons in dissociated cell cultures of the central nervous system. In : Nelson PG., Lieberman M. Excitable cells in tissue culture., New York : Plenum Press, 1980 ; 50 – 80. | en_US |
dc.identifier.citedreference | Macdonald RL., Barker JL. Neuropharmacology of spinal cord neurons in primary dissociated cell culture. In : Nelson PG., Lieberman M. Excitable cells in tissue culture., New York : Plenum Press, 1980 ; 81 – 109. | en_US |
dc.identifier.citedreference | Schulz DW., Macdonald RL. Barbiturate enhancement of GABA-mediated inhibition and activation of chloride ion conductance: correlation with anticonvulsant and anesthetic actions. Brain Res 1981 ; 209 177 – 88. | en_US |
dc.identifier.citedreference | Curtis DR., Duggan AW., Felix D., Johnston GAR. Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat. Brain Res 1971 ; 32 69 – 96. | en_US |
dc.identifier.citedreference | Macdonald RL., Barker JL. Specific antagonism of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: a common mode of convulsant action. Neurology (NY) 1978 ; 28 325 – 30. | en_US |
dc.identifier.citedreference | Nowak LM., Young AB., Macdonald RL. GABA and bicuculline actions on mouse spinal cord and cortical neurons in cell culture. Brain Res 1982 ; 244 155 – 64. | en_US |
dc.identifier.citedreference | Enna SJ., Snyder SH. Properties of Γ-aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractions. Brain Res 1975 ; 100 81 – 97. | en_US |
dc.identifier.citedreference | Frere RC., Macdonald RL., Young AB. GABA binding and bicuculline in spinal cord and cortical membranes from adult rat and from mouse neurons in cell culture. Brain Res 1982 ; 244 145 – 54. | en_US |
dc.identifier.citedreference | Heyer EJ., Nowak LM., Macdonald RL. Bicuculline: a convulsant with synaptic and nonsynaptic actions. Neurology (NY) 1981 ; 31 1381 – 90. | en_US |
dc.identifier.citedreference | Heyer EJ., Nowak LM., Macdonald RL. Mem brane depolarization and prolongation of calcium-dependent action potentials of mouse neurons in cell culture by two convulsants: bicuculline and penicillin. Brain Res 1982 ; 232 41 – 56. | en_US |
dc.identifier.citedreference | Schwindt P., Crill W. Role of a persistent inward current in motoneuron bursting during spinal seizures. J Neurophysiol 1980 ; 43 1296 – 1318. | en_US |
dc.identifier.citedreference | Matsumoto H., Marsan CA. Cortical cellular phenomena in experimental epilepsy: interictal manifestations. Exp Neurol 1964 ; 9 286 – 304. | en_US |
dc.identifier.citedreference | Prince DA. Neurophysiology of epilepsy. Ann Rev Neurosci 1978 ; 1 395 – 415. | en_US |
dc.identifier.citedreference | Schmidt RF. Presynaptic inhibition in the vertebrate central nervous system. Ergeb Physiol Biol Chem Exp Pharmakol 1971 ; 63 20 – 101. | en_US |
dc.identifier.citedreference | Nicoll RA. Pentobarbital: action of frog motoneurons. Brain Res 1975 ; 96 119 – 23. | en_US |
dc.identifier.citedreference | Pole P., Haefely W. Effects of two benzodiazepines, phenobarbitone, and baclofen on synaptic transmission in cat cuneate nucleus. Naunyn Schmiedebergs Arch Pharmacol 1976 ; 294 121 – 31. | en_US |
dc.identifier.citedreference | Barker JL., Ransom BR. Amino acid Pharmacol ogy of mammalian central neurones grown in tissue culture. J Physiol (Lond) 1978 ; 280 331 – 54. | en_US |
dc.identifier.citedreference | Macdonald RL., Barker JL. Enhancement of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: a common mode of anticonvulsant action. Brain Res 1979 ; 167 323 – 36. | en_US |
dc.identifier.citedreference | Macdonald RL., Barker JL. Anticonvulsant and anesthetic barbiturates: different postsynaptic actions on cultured mammalian neurons. Neurology (NY) 1979 ; 29 432 – 47. | en_US |
dc.identifier.citedreference | Adams PR. Drug blockade of open end-plate channels. J Physiol 1976 ; 260 531 – 52. | en_US |
dc.identifier.citedreference | Nicoll RA., Iwamoto ET. Action of pentobarbital on sympathetic ganglion cells. J Neurophysiol 1978 ; 41 977 – 86. | en_US |
dc.identifier.citedreference | Brooks CM., Eccles JC. A study of the effects of anaesthesia on the monosynaptic pathway of the spinal cord. J Neurophysiol 1947 ; 10 349 – 60. | en_US |
dc.identifier.citedreference | Somjen GC., Gill M. The mechanism of the blockade of synaptic transmission in the mammalian spinal cord by diethyl ether and by thiopental. J Pharmacol Exp Ther 1963 ; 140 19 – 30. | en_US |
dc.identifier.citedreference | Loaning Y., Oshima T., Yokota J. Site of action of thiamytal sodium on the monosynaptic spinal reflex pathway in cats. J Neurophysiol 1964 ; 27 408 – 28. | en_US |
dc.identifier.citedreference | Weakly JN. Effect of barbiturates on 'quanta synaptic transmission in spinal motoneurons. J Physiol 1969 ; 204 63 – 77. | en_US |
dc.identifier.citedreference | Cutler RWP., Markowitz D., Dudzinski DS. The effect of barbiturates on [ 3 H]GABA transport in rat cerebral cortex slices. Brain Res 1974 ; 81 189 – 97. | en_US |
dc.identifier.citedreference | Cutler RWP., Young J. Effect of barbiturates on release of endogenous amino acids from rat cortex slices. Neurochem Res 1979 ; 4 319 – 29. | en_US |
dc.identifier.citedreference | Waller MB., Richter JA. Effects of pentobarbital and Ca 2+ on the resting and K + -stimulated release of several endogenous neurotransmitters from rat midbrain slices. Biochem Pharmacol 1980 ; 29 2189 – 98. | en_US |
dc.identifier.citedreference | Potashner SJ., Lake N., Langlois EA., Plouffe L. Jr, Lecavalier D. Pentobarbital: differential effects on the depolarization-induced release of exictatory and inhibitory amino acids from cerebral cortex slices. Brain Res Bull 1980 ; 5 659 – 64. | en_US |
dc.identifier.citedreference | Willow M., Bornstein JC., Johnston GAR. The effects of anaesthetic and convulsant barbiturates on the efflux of [ 3 H]-D-asparate from brain mini-slices. Neurosci Lett 1980 ; 18 185 – 90. | en_US |
dc.identifier.citedreference | Kalant H., Grose W. Effects of ethanol and pentobarbital on release of acetylcholine from cerebral cortex slices. J Pharmacol Exp Ther 1967 ; 158 386 – 95. | en_US |
dc.identifier.citedreference | Richter JA., Waller W. Effects of pentobarbital on the regulation of acetylcholine content and release in different regions of rat brain. Biochem Pharmacol 1977 ; 26 609 – 15. | en_US |
dc.identifier.citedreference | Richter JA., Werling LL. K-stimulated acetylcholine release: inhibition by several barbiturates and chloral hydrate but not by ethanol, chlordiazepoxide or 11-OH-9-tetrahydrocannabinol. J Neurochem 1979 ; 32 935 – 41. | en_US |
dc.identifier.citedreference | Lindmar R., LÖffelholz K., Weide W. Inhibition by pentobarbital of the acetylcholine release from the postganglionic parasympathetic neuron of the heart. J Pharmacol Exp Ther 1979 ; 210 166 – 73. | en_US |
dc.identifier.citedreference | Haycock JW., Levy WB., Cotman CW. Pentobarbital depression of stimulus-secretion coupling in brain-selective inhibition of depolarization-induced calcium-dependent release. Biochem Pharmacol 1977 ; 26 159 – 61. | en_US |
dc.identifier.citedreference | Blaustein MP. Barbiturates block sodium and potassium conductance increases in voltage-clamped lobster axons. J Gen Physiol 1968 ; 51 293 – 307. | en_US |
dc.identifier.citedreference | Narahashi T., Frazier DT., Deguchi T., Cleaves CA., Ernau M. The active form of pentobarbital in squid giant axons. J Pharmacol Exp Ther 1971 ; 177 25 – 33. | en_US |
dc.identifier.citedreference | Schwarz JR. The mode of action of phenobarbital on the excitable membrane of the node of Ranvier. Eur J Pharmacol 1979 ; 56 51 – 60. | en_US |
dc.identifier.citedreference | Heyer EJ., Macdonald RL. Barbiturate reduction of calcium-dependent action potentials: correlation with anesthetic action. Brain Res 1982 ; 236 157 – 71. | en_US |
dc.identifier.citedreference | Fatt P., Katz B. Spontaneous subthreshold activity at motor nerve endings. J Physiol 1952 ; 117 109 – 28. | en_US |
dc.identifier.citedreference | Katz B., Miledi R. A study of synaptic transmission in the absence of nerve impulses. J Physiol 1967 ; 192 407 – 36. | en_US |
dc.identifier.citedreference | Katz B., Miledi R. Tetrodotoxin-resistant electric activity in presynaptic terminals. J Physiol 1969 ; 203 459 – 87. | en_US |
dc.identifier.citedreference | Blaustein MP., Ector AC. Barbiturate inhibition of calcium uptake by depolarized nerve terminals in vitro. Mol Pharmacol 1975 ; 11 369 – 78. | en_US |
dc.identifier.citedreference | Blaustein MP. Barbiturates block calcium uptake by stimulated and potassium-depolarized rat sympathetic ganglia. J Pharmacol Exp Ther 1976 ; 196 80 – 6. | en_US |
dc.identifier.citedreference | Ondrusek MG., Belknap JK., Leslie SW. Effects of acute and chronic barbiturate administration on synaptosomal calcium accumulation. Mol Pharmacol 1979 ; 15 386 – 95. | en_US |
dc.identifier.citedreference | Woodbury DM. Mechanism of action of anticonvulsants. In : Jasper H., Ward A., Pope A. Basic mechanisms of the epilepsies., Boston : Little, Brown, 1969 ; 647 – 81. | en_US |
dc.identifier.citedreference | Swinyard EA., Brown WC., Goodman LS. Comparative assays of antiepileptic drugs in mice and rats. J Pharmacol Exp Ther 1952 ; 106 47 – 59. | en_US |
dc.identifier.citedreference | Goodman LS., Swinyard EA., Brown WC., Schiff-man DO., Grewal MS., Bliss EL. Anticonvulsant properties of 5-phenyl-5-ethyl-hexahydropyrimi-dine-4,6-dione (Mysoline), a new antiepileptic. J Pharmacol Exp Ther 1953 ; 108 428 – 36. | en_US |
dc.identifier.citedreference | Sironi VA., Cabrini G., Porro MG., Ravagnati L., Marossero F. Antiepileptic drug distribution in cerebral cortex, Amnion's horn, and amygdala. J Neurosurg 1980 ; 52 686 – 92. | en_US |
dc.identifier.citedreference | McLean MJ., Macdonald RL. Phenytoin effects on action potentials of fetal mouse spinal cord neurons in cell culture. Soc Neurosci Abstr 1981 ; 7 629. | en_US |
dc.identifier.citedreference | Woodbury DM. Effect of diphenylhydantoin on electrolytes and radiosodium turnover in brain and other tissues of normal, hyponatremic and postictal rats. J Pharmacol Exp Ther 1955 ; 115 74 – 95. | en_US |
dc.identifier.citedreference | Festoff BW., Appel SH. Effect of diphenylhydantoin on synaptosome sodium-potassium ATPase. J Clin Invest 1968 ; 47 2752 – 8. | en_US |
dc.identifier.citedreference | Siegel GJ., Goodwin BB. Sodium-potassium-activated adenosine triphosphatase of brain microsomes: modification of sodium inhibition by diphenylhydantoin. J Clin Invest 1972 ; 51 1164 – 9. | en_US |
dc.identifier.citedreference | Lipicky RJ., Gilbert DL., Stillman IM. Diphenylhydantoin inhibition of sodium conductance in squid giant axon. Proc Natl Acad Sci USA 1972 ; 69 1758 – 60. | en_US |
dc.identifier.citedreference | Schwarz J., Vogel W. Diphenylhydantoin: excitability reducing action in single myelinated nerve fibres. Eur J Pharmacol 1977 ; 44 241 – 9. | en_US |
dc.identifier.citedreference | Neuman RS., Frank GB. Effects of diphenylhydantoin and phenobarbital on voltage-clamped myelinated nerve. Can J Physiol Pharmacol 1977 ; 55 42 – 7. | en_US |
dc.identifier.citedreference | Selzer ME. The effect of phenytoin on the action potential of a vertebrate spinal neuron. Brain Pes 1979 ; 171 511 – 21. | en_US |
dc.identifier.citedreference | Perry JG., McKinney L., DeWeer P. The cellular mode of action of the antiepileptic drug 5,5-diphenylhydantoin. Nature 1978 ; 272 271 – 3. | en_US |
dc.identifier.citedreference | Ferrendelli JA., Kinscherf DA. Similar effects of phenytoin and tetrodotoxin on cyclic nucleotide regulation in depolarized brain tissue. J Pharmacol Exp Ther 1978 ; 207 787 – 93. | en_US |
dc.identifier.citedreference | Tuttle JB., Richelson E. Phenytoin action on the excitable membrane of mouse neuroblastoma. J Pharmacol Exp Ther 1979 ; 211 632 – 7. | en_US |
dc.identifier.citedreference | Sohn RS., Ferrendelli JA. Inhibition of Ca ++ transport into rat brain synaptosomes by diphenylhydantoin. J Pharmacol Exp Ther 1973 ; 185 272 – 5. | en_US |
dc.identifier.citedreference | Hasbani M., Pincus J., Lee SH. Diphenylhydantoin and calcium movement in lobster nerves. Arch Neurol 1974 ; 31 250 – 4. | en_US |
dc.identifier.citedreference | Study RE. Phenytoin inhibition of cyclic guanosine 3'-5'-monophosphate (cGMP) accumulation in neuroblastoma cells by calcium channel blockade. J Pharmacol Exp Ther 1980 ; 215 575 – 81. | en_US |
dc.identifier.citedreference | Pincus JH., Lee SH. Diphenylhydantoin and calcium: relation to norepinephrine release from brain slices. Arch Neurol 1973 ; 29 239 – 44. | en_US |
dc.identifier.citedreference | Camay L., Grundfest S. Excitable membrane stabilization by diphenylhydantoin and calcium. Neuropharmacology 1974 ; 13 : 1097 – 108. | en_US |
dc.identifier.citedreference | Yarri Y., Pincus JH., Argov Z. Depression of synaptic transmission by diphenylhydantoin. Ann Neurol 1977 ; 1 334 – 8. | en_US |
dc.identifier.citedreference | Gage PW., Lonergan M., Torda TA. Presynaptic and postsynaptic depressant effects of phenytoin sodium at the neuromuscular junction. Br J Pharmacol 1980 ; 69 119 – 21. | en_US |
dc.identifier.citedreference | Ayala GF., Johnston D., Lin S., Dichter HN. The mechanism of action of diphenylhydantoin on invertebrate neurons. II. effects on synaptic mechanisms. Brain Res 1977 ; 121 259 – 70. | en_US |
dc.identifier.citedreference | Deisz RA., Lux HD. Diphenylhydantoin prolongs postsynaptic inhibition and iontophoretic GABA action in the crayfish stretch receptor. Neurosci Lett 1977 ; 5 199 – 203. | en_US |
dc.identifier.citedreference | Raabe W., Ayala GF. Diphenylhydantoin increases cortical postsynaptic inhibition. Brain Res 1976 ; 105 597 – 601. | en_US |
dc.identifier.citedreference | Connors BW. A comparison of the effects of pentobarbital and diphenylhydantoin on the GABA sensitivity and excitability of adult sensory ganglion cells. Brain Res 1981 ; 207 357 – 69. | en_US |
dc.identifier.citedreference | Hershkowitz N., Ayala GF. Effects of phenytoin on pyramidal neurons of the rat hippocampus. Brain Res 1981 ; 208 487 – 92. | en_US |
dc.identifier.citedreference | Sastry SR., Phillis JW. Antagonism of glutamate and acetylcholine excitation of rat cerebral cortical neurons by diphenylhydantoin. Gen Pharmacol 1976 ; 7 411 – 3. | en_US |
dc.identifier.citedreference | Toman JEP. The neuropharmacology of antiepileptics. Electroenceph Clin Neurophysiol 1949 ; 1 33 – 44. | en_US |
dc.identifier.citedreference | Korey SR. Effect of dilantin and mesantoin on the giant axon of the squid. Proc Soc Exp Biol Med 1951 ; 76 297 – 9. | en_US |
dc.identifier.citedreference | Raines A., Standaert FG. An effect of diphenylhydantoin on post tetanic hyperpolarization of intramedullary nerve terminals. J Pharmacol Exp Ther 1967 ; 156 591 – 7. | en_US |
dc.identifier.citedreference | Esplin D. Effect of diphenylhydantoin on synaptic transmission in the cat spinal cord and stellate ganglion. J Pharmacol Exp Ther 1957 ; 120 301 – 23. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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