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Effects of Vagus Nerve Stimulation on Progressive Myoclonus Epilepsy of Unverricht-Lundborg Type

dc.contributor.authorSmith, Brien J.en_US
dc.contributor.authorShatz, Rhonnaen_US
dc.contributor.authorElisevich, Kosten_US
dc.contributor.authorBespalova, Irina N.en_US
dc.contributor.authorBurmeister, Margit L.en_US
dc.date.accessioned2010-04-01T15:05:08Z
dc.date.available2010-04-01T15:05:08Z
dc.date.issued2000-08en_US
dc.identifier.citationSmith, Brien; Shatz, Rhonna; Elisevich, Kost; Bespalova, Irina N.; Burmeister, Margit (2000). "Effects of Vagus Nerve Stimulation on Progressive Myoclonus Epilepsy of Unverricht-Lundborg Type." Epilepsia 41(8): 1046-1048. <http://hdl.handle.net/2027.42/65549>en_US
dc.identifier.issn0013-9580en_US
dc.identifier.issn1528-1167en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65549
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10961635&dopt=citationen_US
dc.description.abstractPurpose : A 34-year-old woman with progressive myoclonus epilepsy of Unverricht-Lundborg type was considered for vagus nerve stimulation (VNS) therapy. Methods : After demonstration of intractability to multiple antiepileptic regimens and progressive deterioration in cerebellar function, the patient was implanted with a vagus nerve stimulator and followed for 1 year. Neurological status, seizure frequency, and parameter changes were analyzed. Results : VNS therapy resulted in reduction of seizures (more than 90%) and a significant improvement in cerebellar function demonstrated on neurological examination. The patient reported improved quality of life based in part on her ability to perform activities of daily living. Conclusions : VNS therapy may be considered a treatment option for progressive myoclonus epilepsy. The effects of VNS on seizure control and cerebellar dysfunction may provide clues to the underlying mechanism(s) of action.en_US
dc.format.extent323608 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights2000 International League Against Epilepsyen_US
dc.subject.otherVagus Nerveen_US
dc.subject.otherProgressive Myoclonus Epilepsyen_US
dc.subject.otherElectrical Stimulationen_US
dc.subject.otherEpilepsyen_US
dc.subject.otherSeizureen_US
dc.titleEffects of Vagus Nerve Stimulation on Progressive Myoclonus Epilepsy of Unverricht-Lundborg Typeen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, Henry Ford Health System, Detroit, Michigan, U.S.A.en_US
dc.contributor.affiliationum* Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan, U.S.A.en_US
dc.contributor.affiliationum† Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.contributor.affiliationum† Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.identifier.pmid10961635en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65549/1/j.1528-1157.2000.tb00293.x.pdf
dc.identifier.doi10.1111/j.1528-1157.2000.tb00293.xen_US
dc.identifier.sourceEpilepsiaen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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