Metabolic Syndrome and Cognitive Decline in Elderly Latinos: Findings from the Sacramento Area Latino Study of Aging Study
dc.contributor.author | Yaffe, Kristine | en_US |
dc.contributor.author | Haan, Mary N. | en_US |
dc.contributor.author | Blackwell, Terri | en_US |
dc.contributor.author | Cherkasova, Elena | en_US |
dc.contributor.author | Whitmer, Rachel A. | en_US |
dc.contributor.author | West, Nancy | en_US |
dc.date.accessioned | 2010-04-01T15:07:59Z | |
dc.date.available | 2010-04-01T15:07:59Z | |
dc.date.issued | 2007-05 | en_US |
dc.identifier.citation | Yaffe, Kristine; Haan, Mary; Blackwell, Terri; Cherkasova, Elena; Whitmer, Rachel A.; West, Nancy (2007). "Metabolic Syndrome and Cognitive Decline in Elderly Latinos: Findings from the Sacramento Area Latino Study of Aging Study." Journal of the American Geriatrics Society 55(5): 758-762. <http://hdl.handle.net/2027.42/65598> | en_US |
dc.identifier.issn | 0002-8614 | en_US |
dc.identifier.issn | 1532-5415 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/65598 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17493197&dopt=citation | en_US |
dc.description.abstract | To investigate the effect of metabolic syndrome on cognitive function in an elderly Latino population and to determine whether inflammation modifies this association. DESIGN : A longitudinal cohort study. SETTING : Sacramento area and the surrounding California counties from 1998 to 1999. PARTICIPANTS : One thousand six hundred twenty-four Latinos aged 60 and older who participated in the Sacramento Area Latino Study of Aging. MEASUREMENTS : Baseline metabolic syndrome was calculated using the Third Adult Treatment Panel of the National Cholesterol Education Program. Cognitive function was measured using the Modified Mini-Mental State Examination (3MS) and the Delayed Word-List Recall (DelRec), a verbal memory test. The effect of metabolic syndrome on cognitive change scores was examined using random effects models; in addition, the effect of the individual components of the syndrome on cognitive change was examined. RESULTS : Of the 1,624 participants, 718 (44%) had metabolic syndrome at baseline. Those with metabolic syndrome had worse 3-year change scores on 3MS ( P =.04) and DelRec ( P =.03). Multivariate adjustment attenuated the results for DelRec but not for 3MS. This association was especially pronounced in participants with a high serum level of inflammation, resulting in an average 3MS score 0.64 points lower per year ( P =.03) for those with metabolic syndrome. Individual components of metabolic syndrome were not associated with cognitive decline except for elevated glucose on the DelRec ( P =.02) and high blood pressure on 3MS ( P =.05). CONCLUSION : Metabolic syndrome and inflammation may both contribute to cognitive decline in older people of diverse backgrounds. The results also suggest that, in elderly Latinos, the composite measure of metabolic syndrome is a greater risk for cognitive decline than its individual components. | en_US |
dc.format.extent | 464834 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Inc | en_US |
dc.rights | © 2007, by the American Geriatrics Society | en_US |
dc.subject.other | Metabolic Syndrome | en_US |
dc.subject.other | Cognition | en_US |
dc.subject.other | Dementia | en_US |
dc.subject.other | Diabetes Mellitus | en_US |
dc.subject.other | Elderly | en_US |
dc.title | Metabolic Syndrome and Cognitive Decline in Elderly Latinos: Findings from the Sacramento Area Latino Study of Aging Study | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | School of Public Health, University of Michigan, Ann Arbor, Michigan ; | en_US |
dc.contributor.affiliationother | Psychiatry , | en_US |
dc.contributor.affiliationother | Neurology , | en_US |
dc.contributor.affiliationother | Epidemiology and Biostatistics , and | en_US |
dc.contributor.affiliationother | Geriatrics, University of California at San Francisco, San Francisco, California ; | en_US |
dc.contributor.affiliationother | San Francisco VA Medical Center, San Francisco, California ; | en_US |
dc.contributor.affiliationother | California Pacific Medical Center, San Francisco, California ; and | en_US |
dc.contributor.affiliationother | Division of Research, Kaiser Permanente, Oakland, California. | en_US |
dc.identifier.pmid | 17493197 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/65598/1/j.1532-5415.2007.01139.x.pdf | |
dc.identifier.doi | 10.1111/j.1532-5415.2007.01139.x | en_US |
dc.identifier.source | Journal of the American Geriatrics Society | en_US |
dc.identifier.citedreference | 1. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001 ; 285 : 2486 – 2497. | en_US |
dc.identifier.citedreference | Yaffe K, Kanaya A, Lindquist K et al. The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA 2004 ; 292 : 2237 – 2242. | en_US |
dc.identifier.citedreference | 3. U.S. Census Bureau. National Population Projections. Washington, DC : U.S. Government Printing Office, 2000. | en_US |
dc.identifier.citedreference | Haan MN, Mungas DM, Gonzalez HM et al. Prevalence of dementia in older Latinos : The influence of type 2 diabetes mellitus, stroke and genetic factors. J Am Geriatr Soc 2003 ; 51 : 169 – 177. | en_US |
dc.identifier.citedreference | Teng EL, Chui HC. The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry 1987 ; 48 : 314 – 318. | en_US |
dc.identifier.citedreference | Gonzalez HM, Mungas D, Reed BR et al. A new verbal learning and memory test for English- and Spanish-speaking older people. J Int Neuropsychol Soc 2001 ; 7 : 544 – 555. | en_US |
dc.identifier.citedreference | Radloff L. The CES-D Scale : A self-report depression scale for research in the general population. Appl Psychol Meas 1977 ; 1 : 385 – 401. | en_US |
dc.identifier.citedreference | Cuellar I, Arnold B, Maldonado R. Acculturation Rating Scale for Mexican Americans. II. A revision of the original ARSMA Scale. Hisp J Behav Sci 1995 ; 17 : 274 – 304. | en_US |
dc.identifier.citedreference | Laird NM, Ware JH. Random-effects models for longitudinal data. Biometrics 1982 ; 38 : 963 – 974. | en_US |
dc.identifier.citedreference | Launer LJ, Masaki K, Petrovitch H et al. The association between midlife blood pressure levels and late-life cognitive function. The Honolulu-Asia Aging Study. JAMA 1995 ; 274 : 1846 – 1851. | en_US |
dc.identifier.citedreference | Knopman D, Boland LL, Mosley T et al. Cardiovascular risk factors and cognitive decline in middle-aged adults. Neurology 2001 ; 56 : 42 – 48. | en_US |
dc.identifier.citedreference | Moroney JT, Tang MX, Berglund L et al. Low-density lipoprotein cholesterol and the risk of dementia with stroke. JAMA 1999 ; 282 : 254 – 260. | en_US |
dc.identifier.citedreference | Evans RM, Emsley CL, Gao S et al. Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease : A population-based study of African Americans. Neurology 2000 ; 54 : 240 – 242. | en_US |
dc.identifier.citedreference | Wu JH, Haan MN, Liang J et al. Impact of diabetes on cognitive function among older Latinos : A population-based cohort study. J Clin Epidemiol 2003 ; 56 : 686 – 693. | en_US |
dc.identifier.citedreference | Yaffe K, Blackwell T, Kanaya AM et al. Diabetes, impaired fasting glucose, and development of cognitive impairment in older women. Neurology 2004 ; 63 : 658 – 663. | en_US |
dc.identifier.citedreference | Grodstein F, Chen J, Wilson RS et al. Type 2 diabetes and cognitive function in community-dwelling elderly women. Diabetes Care 2001 ; 24 : 1060 – 1065. | en_US |
dc.identifier.citedreference | Barzilay JI, Abraham L, Heckbert SR et al. The relation of markers of inflammation to the development of glucose disorders in the elderly. The Cardiovascular Health Study. Diabetes 2001 ; 50 : 2384 – 2389. | en_US |
dc.identifier.citedreference | Pradhan AD, Manson JE, Rifai N et al. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001 ; 286 : 327 – 334. | en_US |
dc.identifier.citedreference | Yaffe K, Lindquist K, Penninx BW et al. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology 2003 ; 61 : 76 – 80. | en_US |
dc.identifier.citedreference | McGeer EG, McGeer PL. Brain inflammation in Alzheimer disease and the therapeutic implications. Curr Pharm Des 1999 ; 5 : 821 – 836. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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