Novel Peptide Ligands of RGS4 from a Focused One-Bead, One-Compound Library
dc.contributor.author | Roof, Rebecca A. | en_US |
dc.contributor.author | Sobczyk-Kojiro, Katarzyna | en_US |
dc.contributor.author | Turbiak, Anjanette J. | en_US |
dc.contributor.author | Roman, David L. | en_US |
dc.contributor.author | Pogozheva, Irina D. | en_US |
dc.contributor.author | Blazer, Levi L. | en_US |
dc.contributor.author | Neubig, Richard R. | en_US |
dc.contributor.author | Mosberg, Henry I. | en_US |
dc.date.accessioned | 2010-04-01T15:08:22Z | |
dc.date.available | 2010-04-01T15:08:22Z | |
dc.date.issued | 2008-08 | en_US |
dc.identifier.citation | Roof, Rebecca A.; Sobczyk-Kojiro, Katarzyna; Turbiak, Anjanette J.; Roman, David L.; Pogozheva, Irina D.; Blazer, Levi L.; Neubig, Richard R.; Mosberg, Henry I. (2008). "Novel Peptide Ligands of RGS4 from a Focused One-Bead, One-Compound Library." Chemical Biology & Drug Design 72(2): 111-119. <http://hdl.handle.net/2027.42/65605> | en_US |
dc.identifier.issn | 1747-0277 | en_US |
dc.identifier.issn | 1747-0285 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/65605 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18637987&dopt=citation | en_US |
dc.format.extent | 378217 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | Journal compilation © 2008 Blackwell Munksgaard | en_US |
dc.subject.other | Focused Library | en_US |
dc.subject.other | One-bead One-compound Library | en_US |
dc.subject.other | Protein–Protein Interaction Inhibitors | en_US |
dc.subject.other | Regulators of G-protein Signaling | en_US |
dc.subject.other | Structure–Activity Relationship | en_US |
dc.title | Novel Peptide Ligands of RGS4 from a Focused One-Bead, One-Compound Library | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, 1301 MSRB III/SPC5632, Ann Arbor, MI 48103, USA | en_US |
dc.contributor.affiliationum | Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065, USA | en_US |
dc.identifier.pmid | 18637987 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/65605/1/j.1747-0285.2008.00687.x.pdf | |
dc.identifier.doi | 10.1111/j.1747-0285.2008.00687.x | en_US |
dc.identifier.source | Chemical Biology & Drug Design | en_US |
dc.identifier.citedreference | Hepler J.R. ( 1999 ) Emerging roles for RGS proteins in cell signalling. Trends Pharmacol Sci ; 9 : 376 – 382. | en_US |
dc.identifier.citedreference | Berman D.M., Kozasa T., Gilman A.G. ( 1996 ) The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis. J Biol Chem ; 44 : 27209 – 27212. | en_US |
dc.identifier.citedreference | Wang Q., Liu M., Mullah B., Siderovski D.P., Neubig R.R. ( 2002 ) Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells. J Biol Chem ; 28 : 24949 – 24958. | en_US |
dc.identifier.citedreference | Xu X., Zeng W., Popov S., Berman D.M., Davignon I., Yu K., Yowe D., Offermanns S., Muallem S., Wilkie T.M. ( 1999 ) RGS proteins determine signaling specificity of Gq-coupled receptors. J Biol Chem ; 6 : 3549 – 3556. | en_US |
dc.identifier.citedreference | Hague C., Bernstein L.S., Ramineni S., Chen Z., Minneman K.P., Hepler J.R. ( 2005 ) Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop. J Biol Chem ; 29 : 27289 – 27295. | en_US |
dc.identifier.citedreference | Krumins A.M., Barker S.A., Huang C., Sunahara R.K., Yu K., Wilkie T.M., Gold S.J., Mumby S.M. ( 2004 ) Differentially regulated expression of endogenous RGS4 and RGS7. J Biol Chem ; 4 : 2593 – 2599. | en_US |
dc.identifier.citedreference | Gold S.J., Ni Y.G., Dohlman H.G., Nestler E.J. ( 1997 ) Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain. J Neurosci ; 20 : 8024 – 8037. | en_US |
dc.identifier.citedreference | Traynor J.R., Neubig R.R. ( 2005 ) Regulators of G protein signaling and drugs of abuse. Mol Interv ; 1 : 30 – 41. | en_US |
dc.identifier.citedreference | Neubig R.R. ( 2002 ) Regulators of G protein signaling (RGS proteins): novel central nervous system drug targets. J Pept Res ; 6 : 312 – 316. | en_US |
dc.identifier.citedreference | Zhong H., Neubig R.R. ( 2001 ) Regulator of G protein signaling proteins: novel multifunctional drug targets. J Pharmacol Exp Ther ; 3 : 837 – 845. | en_US |
dc.identifier.citedreference | Cho H., Park C., Hwang I.Y., Han S.B., Schimel D., Despres D., Kehrl J.H. ( 2008 ) Rgs5 targeting leads to chronic low blood pressure and a lean body habitus. Mol Cell Biol ; 28 : 2590 – 2597. | en_US |
dc.identifier.citedreference | Ding J., Guzman J.N., Tkatch T., Chen S., Goldberg J.A., Ebert P.J., Levitt P., Wilson C.J., Hamm H.E., Surmeier D.J. ( 2006 ) RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion. Nat Neurosci ; 6 : 832 – 842. | en_US |
dc.identifier.citedreference | Rodriguez-Munoz M., de la Torre-Madrid E., Gaitan G., Sanchez-Blazquez P., Garzon J. ( 2007 ) RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons. Cell Signal ; 12 : 2558 – 2571. | en_US |
dc.identifier.citedreference | Rahman Z., Schwarz J., Gold S.J., Zachariou V., Wein M.N., Choi K.H., Kovoor A. et al. ( 2003 ) RGS9 modulates dopamine signaling in the basal ganglia. Neuron ; 6 : 941 – 952. | en_US |
dc.identifier.citedreference | Druey K.M. ( 2003 ) Regulators of G protein signalling: potential targets for treatment of allergic inflammatory diseases such as asthma. Expert Opin Ther Targets ; 4 : 475 – 484. | en_US |
dc.identifier.citedreference | Usui I., Imamura T., Satoh H., Huang J., Babendure J.L., Hupfeld C.J., Olefsky J.M. ( 2004 ) GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. EMBO J ; 14 : 2821 – 2829. | en_US |
dc.identifier.citedreference | Huang X., Charbeneau R.A., Fu Y., Kaur K., Gerin I., MacDougald O.A., Neubig R.R. ( 2008 ) Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele. Diabetes ; 1 : 77 – 85. | en_US |
dc.identifier.citedreference | Heo K., Ha S.H., Chae Y.C., Lee S., Oh Y.S., Kim Y.H., Kim S.H., Kim J.H., Mizoguchi A., Itoh T.J., Kwon H.M., Ryu S.H., Suh P.G. ( 2006 ) RGS2 promotes formation of neurites by stimulating microtubule polymerization. Cell Signal ; 12 : 2182 – 2192. | en_US |
dc.identifier.citedreference | Boss C.N., Grunebach F., Brauer K., Hantschel M., Mirakaj V., Weinschenk T., Stevanovic S., Rammensee H.G., Brossart P. ( 2007 ) Identification and characterization of T-cell epitopes deduced from RGS5, a novel broadly expressed tumor antigen. Clin Cancer Res ; 11 : 3347 – 3355. | en_US |
dc.identifier.citedreference | Abramow-Newerly M., Roy A.A., Nunn C., Chidiac P. ( 2006 ) RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins. Cell Signal ; 5 : 579 – 591. | en_US |
dc.identifier.citedreference | Bernstein L.S., Grillo A.A., Loranger S.S., Linder M.E. ( 2000 ) RGS4 binds to membranes through an amphipathic alpha-helix. J Biol Chem ; 24 : 18520 – 18526. | en_US |
dc.identifier.citedreference | Bernstein L.S., Ramineni S., Hague C., Cladman W., Chidiac P., Levey A.I., Hepler J.R. ( 2004 ) RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling. J Biol Chem ; 20 : 21248 – 21256. | en_US |
dc.identifier.citedreference | Gu S., He J., Ho W.T., Ramineni S., Thal D.M., Natesh R., Tesmer J.J., Hepler J.R., Heximer S.P. ( 2007 ) Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members. J Biol Chem ; 45 : 33064 – 33075. | en_US |
dc.identifier.citedreference | Jin Y., Zhong H., Omnaas J.R., Neubig R.R., Mosberg H.I. ( 2004 ) Structure-based design, synthesis, and pharmacologic evaluation tf peptide RGS4 inhibitors. J Pept Res ; 2 : 141 – 146. | en_US |
dc.identifier.citedreference | Tesmer J.J., Berman D.M., Gilman A.G., Sprang S.R. ( 1997 ) Structure of RGS4 bound to AlF4-activated G(i alpha1): stabilization of the transition state for GTP hydrolysis. Cell ; 2 : 251 – 261. | en_US |
dc.identifier.citedreference | Roof R.A., Jin Y., Roman D.L., Sunahara R.K., Ishii M., Mosberg H.I., Neubig R.R. ( 2006 ) Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chem Biol Drug Des ; 4 : 266 – 274. | en_US |
dc.identifier.citedreference | Jameson E.E., Roof R.A., Whorton M.R., Mosberg H.I., Sunahara R.K., Neubig R.R., Kennedy R.T. ( 2005 ) Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues. J Biol Chem ; 9 : 7712 – 7719. | en_US |
dc.identifier.citedreference | Lam K.S., Salmon S.E., Hersh E.M., Hruby V.J., Kazmierski W.M., Knapp R.J. ( 1991 ) A new type of synthetic peptide library for identifying ligand-binding activity. Nature ; 6348 : 82 – 84. | en_US |
dc.identifier.citedreference | Lan K.L., Sarvazyan N.A., Taussig R., Mackenzie R.G., DiBello P.R., Dohlman H.G., Neubig R.R. ( 1998 ) A point mutation in Galphao and Galphai1 blocks interaction with regulator of G protein signaling proteins. J Biol Chem ; 21 : 12794 – 12797. | en_US |
dc.identifier.citedreference | Lan K.L., Zhong H., Nanamori M., Neubig R.R. ( 2000 ) Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Galphai and Galphao deactivation. Galpha specificity of RGS4 AND RGS7. J Biol Chem ; 43 : 33497 – 33503. | en_US |
dc.identifier.citedreference | Lee E., Linder M.E., Gilman A.G. ( 1994 ) Expression of G-protein alpha subunits in Escherichia coli. Methods Enzymol ; 237 : 146 – 164. | en_US |
dc.identifier.citedreference | Roman D.L., Talbot J.N., Roof R.A., Sunahara R.K., Traynor J.R., Neubig R.R. ( 2007 ) Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Mol Pharmacol ; 1 : 169 – 175. | en_US |
dc.identifier.citedreference | Cabilly S. ( 1998 ) Combinatorial Peptide Library Protocols. Totowa, NJ : Humana Press. | en_US |
dc.identifier.citedreference | Olivos H.J., Bachhawat-Sikder K., Kodadek T. ( 2003 ) Quantum dots as a visual aid for screening bead-bound combinatorial libraries. Chembiochem ; 11 : 1242 – 1245. | en_US |
dc.identifier.citedreference | Kimple A.J., Willard F.S., Giguere P.M., Johnston C.A., Mocanu V., Siderovski D.P. ( 2007 ) The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face. Biochem Biophys Acta ; 9 : 1213 – 1220. | en_US |
dc.identifier.citedreference | Whitty A., Kumaravel G. ( 2006 ) Between a rock and a hard place? Nat Chem Biol ; 3 : 112 – 118. | en_US |
dc.identifier.citedreference | Fry D.C., Vassilev L.T. ( 2005 ) Targeting protein–protein interactions for cancer therapy. J Mol Med ; 12 : 955 – 963. | en_US |
dc.identifier.citedreference | Scott J.K., Huang S.F., Gangadhar B.P., Samoriski G.M., Clapp P., Gross R.A., Taussig R., Smrcka A.V. ( 2001 ) Evidence that a protein–protein interaction ‘hot spot’ on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors. EMBO J ; 4 : 767 – 776. | en_US |
dc.identifier.citedreference | Trosset J.Y., Dalvit C., Knapp S., Fasolini M., Veronesi M., Mantegani S., Gianellini L.M., Catana C., Sundstrom M., Stouten P.F., Moll J.K. ( 2006 ) Inhibition of protein–protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins ; 1 : 60 – 67. | en_US |
dc.identifier.citedreference | Thanos C.D., DeLano W.L., Wells J.A. ( 2006 ) Hot-spot mimicry of a cytokine receptor by a small molecule. Proc Natl Acad Sci USA ; 42 : 15422 – 15427. | en_US |
dc.identifier.citedreference | Wells J.A., McClendon C.L. ( 2007 ) Reaching for high-hanging fruit in drug discovery at protein–protein interfaces. Nature ; 7172 : 1001 – 1009. | en_US |
dc.identifier.citedreference | Young K.H., Wang Y., Bender C., Ajit S., Ramirez F., Gilbert A., Nieuwenhuijsen B.W. ( 2004 ) Yeast-based screening for inhibitors of RGS proteins. Methods Enzymol ; 389 : 277 – 301. | en_US |
dc.identifier.citedreference | Ishii M., Fujita S., Yamada M., Hosaka Y., Kurachi Y. ( 2005 ) Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action. Biochem J ; 385 : 65 – 73. | en_US |
dc.identifier.citedreference | Fear G., Komarnytsky S., Raskin I. ( 2007 ) Protease inhibitors and their peptidomimetic derivatives as potential drugs. Pharmacol Ther ; 2 : 354 – 368. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.