Tetraenoic Species Are Conserved in Muscarinically Enhanced Inositide Turnover
dc.contributor.author | Rooijen, Lucio A. A. | en_US |
dc.contributor.author | Hajra, Amiya K. | en_US |
dc.contributor.author | Agranoff, Bernard W. | en_US |
dc.date.accessioned | 2010-04-01T15:09:58Z | |
dc.date.available | 2010-04-01T15:09:58Z | |
dc.date.issued | 1985-02 | en_US |
dc.identifier.citation | Rooijen, Lucio A. A.; Hajra, Amiya K.; Agranoff, Bernard W. (1985). "Tetraenoic Species Are Conserved in Muscarinically Enhanced Inositide Turnover." Journal of Neurochemistry 44(2): 540-543. <http://hdl.handle.net/2027.42/65633> | en_US |
dc.identifier.issn | 0022-3042 | en_US |
dc.identifier.issn | 1471-4159 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/65633 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2981288&dopt=citation | en_US |
dc.description.abstract | Carbamylcholine enhances the labeling of phosphatidate and phosphatidylinositol from 32 P i in nerve endings. Approximately 74% of labeled phosphatidate and 85% of labeled phosphatidylinositol produced on muscarinic stimulation are accounted for by tetraenoic species, as detected by argentation TLC. Incubation of membranes derived from nerve endings with [Γ- 32 P]ATP under conditions of phosphodiesteratic degradation of endogenous polyphosphoinositides resulted in increased labeling of phosphatidate. Approximately 78% of the newly formed phosphatidate was in a tetraenoic fraction. It is concluded that in muscarinically stimulated nerve endings, the diacylglycerol moiety is conserved following diacylglycerol release from polyphosphoinositides through its resynthesis to inositol lipid via phosphatidate. | en_US |
dc.format.extent | 440302 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1985 International Society for Neurochemistry | en_US |
dc.subject.other | Diacylglycerol | en_US |
dc.subject.other | Inositol Lipids | en_US |
dc.subject.other | Muscarinic Receptor | en_US |
dc.subject.other | Nerve Endings | en_US |
dc.subject.other | Polyphosphoinositides | en_US |
dc.subject.other | Tetraenoic Lipids | en_US |
dc.title | Tetraenoic Species Are Conserved in Muscarinically Enhanced Inositide Turnover | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neuroscience Building, Mental Health Research Institute and Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 2981288 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/65633/1/j.1471-4159.1985.tb05446.x.pdf | |
dc.identifier.doi | 10.1111/j.1471-4159.1985.tb05446.x | en_US |
dc.identifier.source | Journal of Neurochemistry | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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