View Item 

Show simple item record

Effects of Chronic Morphine Treatment on Β-Endorphin-Related Peptides in the Caudal Medulla and Spinal Cord
dc.contributor.authorBronstein, David M.en_US
dc.contributor.authorGutstein, Howard B.en_US
dc.contributor.authorAkil, Hudaen_US
dc.date.accessioned2010-04-01T15:11:32Z
dc.date.available2010-04-01T15:11:32Z
dc.date.issued1993-06en_US
dc.identifier.citationBronstein, David M.; Gutstein, Howard B.; Akil, Huda (1993). "Effects of Chronic Morphine Treatment on Β-Endorphin-Related Peptides in the Caudal Medulla and Spinal Cord." Journal of Neurochemistry 60(6): 2304-2307. <http://hdl.handle.net/2027.42/65660>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65660
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8492132&dopt=citationen_US
dc.description.abstractThe effects of chronic morphine treatment on Β-endorphin (ΒE)-immunoreactive (ΒE-ir) peptide levels were determined in the rat caudal medulla and different areas of the spinal cord. Seven days of morphine pelleting had no effect on total ΒE-ir peptides in the caudal medulla. In contrast, it significantly increased ΒE-ir peptide concentrations in the cervical and thoracic regions of the spinal cord compared with placebo-pelleted controls, whereas in the lumbosacral region this trend did not reach statistical significance. Injections of the opiate receptor antagonist naloxone 1 h before the rats were killed had no effect on the morphine-induced increases in the cord. Chromatographic analyses revealed that enzymatic processing of ΒE-related peptides in the spinal cord seemed unaffected by the morphine and/or naloxone treatments. In light of previous data showing that morphine down-regulates ΒE biosynthesis in the hypothalamus, the present results suggest that the regulation of ΒE-ir peptides in the spinal cord is distinct from that found in other CNS areas. These data provide support for previous results suggesting that ΒE-expressing neurons may be intrinsic to the spinal cord.en_US
dc.format.extent402580 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1993 International Society for Neurochemistryen_US
dc.subject.otherOpiateen_US
dc.subject.otherEndogenous Opioiden_US
dc.subject.otherProopiomelanocortinen_US
dc.subject.otherMorphineen_US
dc.subject.otherNucleus Tractus Solitarius.en_US
dc.titleEffects of Chronic Morphine Treatment on Β-Endorphin-Related Peptides in the Caudal Medulla and Spinal Corden_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum* Department ofAnesthesiology, University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.contributor.affiliationotherMental Health Research Instituteen_US
dc.identifier.pmid8492132en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65660/1/j.1471-4159.1993.tb03518.x.pdf
dc.identifier.doi10.1111/j.1471-4159.1993.tb03518.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
dc.identifier.citedreferenceAkil H., Watson S. J., Barchas J. D., and Li C. H. ( 1979 ) Beta-endorphin immunoreactivity in rat and human blood: radioimmunoassay, comparative levels, and physiological alterations. Life Sci. 24, 1659 – 1666.en_US
dc.identifier.citedreferenceAkil H., Watson S. J., Young E., Lewis M. E., Khachaturian H., and Walker J. M. ( 1984 ) Endogenous opioids: biology and function. Annu. Rev. Neurosci. 7, 223 – 255.en_US
dc.identifier.citedreferenceBerglund L. A., Millington W. R., and Simpkins J. W. ( 1989 ) Gonadal steroid and chronic morphine treatment do not change the posttranslational processing of Β-endorphin in the rat brain. Life Sci. 44, 591 – 601.en_US
dc.identifier.citedreferenceBloom F., Battenberg E., Rossier J., Ling N., and Guillemin R. ( 1978 ) Neurons containing beta-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies. Proc. Natl. Acad. Sci. USA 75, 1591 – 1595.en_US
dc.identifier.citedreferenceBronstein D. M., Przewlocki R., and Akil H. ( 1990 ) Effects of morphine treatment on pro-opiomelanocortin systems in rat brain. Brain Res. 519, 102 – 111.en_US
dc.identifier.citedreferenceBronstein D. M., Day N. C., Gutstein H. B., Trujillo K. A., and Akil H. ( 1993 ) Pre- and posttranslational regulation of Β-endorphin biosynthesis in the CNS: effects of chronic naltrexone treatment. J. Neurochem. 60, 40 – 49.en_US
dc.identifier.citedreferenceDores R. M., Jain M., and Akil H. ( 1986 ) Characterization of the forms of Β-endorphin and Α-MSH in the caudal medulla of the rat and guinea pig. Brain Res. 377, 251 – 260.en_US
dc.identifier.citedreferenceGianoulakis C. and Angelogianni P. ( 1989 ) Characterization of Β-endorphin peptides in the spinal cord of the rat. Peptides 10, 1049 – 1054.en_US
dc.identifier.citedreferenceGutstein H. B., Bronstein D. M., and Akil H. ( 1992 ) Β-Endorphin processing and cellular origins in rat spinal cord. Pain 51, 241 – 247.en_US
dc.identifier.citedreferenceKhachaturian H., Lewis M. E., Tsou K., and Watson S. J. ( 1985 ) Β-Endorphin, Α-MSH, ACTH, and related peptides, in Handbook of Chemical Neuroanatomy, Vol. 4: GABA and Neuropeptides in the CNS, Part I ( BjÖrklund A. and HÖkfelt T., eds ), pp. 216 – 272. Elsevier, Amsterdam.en_US
dc.identifier.citedreferenceKrieger D. T., Liotta A. S., Brownstein M. J., and Zimmerman E. A. ( 1980 ) ACTH, Β-lipotropin, and related peptides in brain, pituitary, and blood. Recent Prog. Harm. Res. 36, 277 – 344.en_US
dc.identifier.citedreferenceMocchetti I., Ritter A., and Costa E. ( 1989 ) Down-regulation of pro-opiomelanocortin synthesis and beta-endorphin utilization in hypothalamus of morphine-tolerant rats. J. Mol. Neurosci. 1, 33 – 38.en_US
dc.identifier.citedreferencePalkovits M. and Eskay R. L. ( 1987 ) Distribution and possible origin of Β-endorphin and ACTH in discrete brainstem nuclei of rals. Neuropeptides 9, 123 – 137.en_US
dc.identifier.citedreferencePalkovits M., Mezey E., and Eskay R. L. ( 1987 ) Pro-opiomelanocortin-derived peptides (ACTH/Β-endorphin/Α-MSH) in brainstem baroreceptor areas of the rat. Brain Res. 436, 323 – 328.en_US
dc.identifier.citedreferencePlantinga L. C., Verhaagen J., Edwards P. M., Schrama L. H., Burbach J. P. H., and Gispen W. H. ( 1992 ) Expression of the pro-opiomelanocortin gene in dorsal root ganglia, spinal cord and sciatic nerve after sciatic nerve crush in the rat. Mol. Brain Res. 16, 135 – 142.en_US
dc.identifier.citedreferenceSchwartzberg D. G. and Nakane P. K. ( 1983 ) ACTH-related peptide containing neurons within the medulla oblongata of the rat. Brain Res. 276, 351 – 356.en_US
dc.identifier.citedreferenceTsou K., Khachaturian H., Akil H., and Watson S. J. ( 1986 ) Immunocytochemical localization of pro-opiomelanocortin-derived peptides in the adult rat spinal cord. Brain Res. 378, 28 – 35.en_US
dc.identifier.citedreferenceWatson S. J., Barchas J. D., and Li C. H. ( 1977 ) Beta-lipotropin: localization in cells and axons in rat brain by immunocytochemistry. Proc. Natl. Acad. Sci. USA 74, 5155 – 5158.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
j.1471-4159.1993.tb03518.x.pdf
Size:
393.1KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.