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The Influence of Latent Viral Infection on Rate of Cognitive Decline over 4 Years
dc.contributor.authorAiello, Allison E.en_US
dc.contributor.authorHaan, Mary N.en_US
dc.contributor.authorBlythe, Lynnen_US
dc.contributor.authorMoore, Karien_US
dc.contributor.authorGonzalez, Jeffrey M.en_US
dc.contributor.authorJagust, William J.en_US
dc.date.accessioned2010-04-01T15:13:02Z
dc.date.available2010-04-01T15:13:02Z
dc.date.issued2006-07en_US
dc.identifier.citationAiello, Allison E.; Haan, Mary N.; Blythe, Lynn; Moore, Kari; Gonzalez, Jeffrey M.; Jagust, William (2006). "The Influence of Latent Viral Infection on Rate of Cognitive Decline over 4 Years." Journal of the American Geriatrics Society 54(7): 1046-1054. <http://hdl.handle.net/2027.42/65686>en_US
dc.identifier.issn0002-8614en_US
dc.identifier.issn1532-5415en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65686
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16866674&dopt=citationen_US
dc.description.abstractTo examine whether cytomegalovirus (CMV) and herpes simplex virus type-1 (HSV-1) are associated with cognitive decline over a 4-year period and to assess whether C-reactive protein (CRP) modifies these relationships. DESIGN : Prospective cohort study over a 4-year period. SETTING : Community-dwelling elderly population. PARTICIPANTS : The sample was a subset (1,204/1,789) of participants in the Sacramento Area Latino Study on Aging (SALSA) aged 60 to 100. MEASUREMENTS : Participants were screened annually over a 4-year period for cognitive function and episodic memory. Cognitive function was assessed using the modified Mini-Mental State Examination, and episodic memory was assessed using a word list-learning test of delayed recall. Baseline serum samples were assayed for levels of immunoglobulin G antibodies to CMV and HSV-1 and for levels of CRP. RESULTS : There was a significantly higher rate of cognitive decline over the 4-year period in subjects with the highest CMV antibody levels at baseline than in individuals with the lowest levels (Β=−0.053, standard error =0.018; P =.003), after controlling for age, sex, education, income, and chronic health conditions. There was no association between HSV-1 antibody levels and cognitive decline. CRP did not modify the relationship between viral antibody levels and cognitive decline. CONCLUSION : This is the first study to show that individuals with higher levels of antibody to CMV experience a more-rapid rate of cognitive decline than those with lower levels. Understanding the mechanisms by which CMV influences cognition may aid development of intervention strategies targeting infection, viral reactivation, and immune response over the life course.en_US
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dc.publisherBlackwell Publishing Incen_US
dc.rights© 2006, The American Geriatrics Societyen_US
dc.subject.otherHerpesen_US
dc.subject.otherDementiaen_US
dc.subject.otherRate of Cognitive Declineen_US
dc.subject.otherElderlyen_US
dc.subject.otherCommunityen_US
dc.titleThe Influence of Latent Viral Infection on Rate of Cognitive Decline over 4 Yearsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeriatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan ; anden_US
dc.contributor.affiliationotherCenter for Social Epidemiology and Population Health anden_US
dc.contributor.affiliationotherSchool of Public Health and Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, California .en_US
dc.identifier.pmid16866674en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65686/1/j.1532-5415.2006.00796.x.pdf
dc.identifier.doi10.1111/j.1532-5415.2006.00796.xen_US
dc.identifier.sourceJournal of the American Geriatrics Societyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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