RAT AND MOUSE BRAIN HISTAMINE N -METHYLTRANSFERASE: MODULATION BY METHYLATED INDOLEAMINES 1
dc.contributor.author | Sellinger, Otto Z. | en_US |
dc.contributor.author | Schatz, Robert A. | en_US |
dc.contributor.author | Ohlsson, W. G. | en_US |
dc.date.accessioned | 2010-04-01T15:27:01Z | |
dc.date.available | 2010-04-01T15:27:01Z | |
dc.date.issued | 1978-02 | en_US |
dc.identifier.citation | Sellinger, O. Z.; Schatz, R. A.; Ohlsson, W. G. (1978). "RAT AND MOUSE BRAIN HISTAMINE N -METHYLTRANSFERASE: MODULATION BY METHYLATED INDOLEAMINES 1 ." Journal of Neurochemistry 30(2): 437-445. <http://hdl.handle.net/2027.42/65930> | en_US |
dc.identifier.issn | 0022-3042 | en_US |
dc.identifier.issn | 1471-4159 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/65930 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=624949&dopt=citation | en_US |
dc.description.abstract | A purification procedure for rat and mouse brain histamine N -methyltransferase (HMT, EC 2.1.1.8) is described which achieves the preparation of 87-fold purified rat brain and 166-fold purified mouse brain enzyme. The purified HMT (MW 29,000) is inhibited by a number of physiologically and pharmacologically active amines, among them several methylated indoleamines, at concentrations above 5 ± 10 -6 M. At concentrations below 1 ± 10 -7 M, most of the methylated indoleamines stimulate HMT , provided histamine is maintained at, or close to, its optimal concentration as an HMT substrate, namely 1 ± 10 -5 M. A study of the nature of the inhibitory process revealed a non-competitive inhibition of HMT by dopamine as against a competitive inhibition of the enzyme by most methylated indoleamines. Increasing the concentration of histamine beyond the optimal value, i.e. to inhibitory levels, resulted in less stimulation. The findings support the notion that MSO elicits the formation in selected brain cells of supranormal amounts of several methylated indoleamines which are able to stimulate HMT (and possibly other methyltransferases, see Salas et al. , 1977), thereby causing the depletion of the cerebral levels of S-adenosyl-L-methionine, reported previously (Schatz & Sellinger, 1975b). | en_US |
dc.format.extent | 678606 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1978 International Society for Neurochemistry | en_US |
dc.title | RAT AND MOUSE BRAIN HISTAMINE N -METHYLTRANSFERASE: MODULATION BY METHYLATED INDOLEAMINES 1 | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Laboratory of Neurochemistry, Mental Health Research Institute. University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 624949 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/65930/1/j.1471-4159.1978.tb06548.x.pdf | |
dc.identifier.doi | 10.1111/j.1471-4159.1978.tb06548.x | en_US |
dc.identifier.source | Journal of Neurochemistry | en_US |
dc.identifier.citedreference | Axelrod J. & Vesell E. S. ( 1970 ) Molec. Pharmac. 6, 78 – 84. | en_US |
dc.identifier.citedreference | Barth H., Lorenz W. & Niemeyer I. ( 1973 ) Hoppe-Seyler's Z. Physiol. Chem. 354, 1021 – 1026. | en_US |
dc.identifier.citedreference | Brown D. D., Tomchick R. & Axelrod J. ( 1959 ) J. biol. Chem. 234, 2948 – 2950. | en_US |
dc.identifier.citedreference | Deguchi T. & Barchas J. ( 1971 ) J. biol. Chem. 246, 3175 – 3181. | en_US |
dc.identifier.citedreference | Diaz Borges J. M. & Urbina CH. M. ( 1976 ) Abstr. 31st Meet. Soc. Biol. Psych. p. 117. | en_US |
dc.identifier.citedreference | Diez Altares M. C. & Sellinger O. Z. ( 1976 ) Enzyme 21, 53 – 65. | en_US |
dc.identifier.citedreference | Duch D. S., Bowers S. W., Brenckman W. D. Jr. & Nichol C. A. ( 1976 ) Pharmacologist 18, 205. | en_US |
dc.identifier.citedreference | Garbarg M., Baudry M., Benda P. & Schwartz J.-C. ( 1975 ) Brain Res. 83, 538 – 541. | en_US |
dc.identifier.citedreference | Gillin J. C., Kaplan J., Stillman R. & Wyatt R. J. ( 1976a ) Am. J. Psychiat. 133, 203 – 208. | en_US |
dc.identifier.citedreference | Gillin J. C., Tinklenberg J., Stoff D. M., Stillman R., Shortlidge J. & Wyatt R. J. ( 1976b ) Biol. Psych. 11, 355 – 358. | en_US |
dc.identifier.citedreference | Gustafsson A. & Forschell G. P. ( 1963 ) Acta Chem. scand. 17, 541 – 548. | en_US |
dc.identifier.citedreference | Hartley R. & Smith J. A. ( 1973 ) J. Pharm. Pharmac. 25, 751 – 752. | en_US |
dc.identifier.citedreference | Kouvelas E. D., Savakis Ch. E., Tzebelikos T., Bonatsos G. & Mitrossilis S. ( 1976 ) Experientia 32, 1136 – 1138. | en_US |
dc.identifier.citedreference | Lew J. Y., Matsumoto Y., Pearson J., Goldstein M., Hokfelt T. & Fuxe K. ( 1977 ) Brain Res. 119, 199 – 210. | en_US |
dc.identifier.citedreference | Lew J. Y., Miyamoto T. & Goldstein M. ( 1976 ) Biochem. Pharmac. 25, 1433 – 1434. | en_US |
dc.identifier.citedreference | Lombardini J. B., Chou T.-C. & Talalav P. ( 1973 ) Biochem. J., Lond. 135, 43 – 57. | en_US |
dc.identifier.citedreference | Lorenz W., Reimann H.-J., Barth J., Kusche J., Meyer R., Doenicke A. & Hutzel M. ( 1972 ) Hoppe Seyler's Z. Physiol. Chem. 353, 911 – 920. | en_US |
dc.identifier.citedreference | Lowry O. H., Rosebrough N. J., Farr A. L. & Randall R. J. ( 1951 ) J. biol. Chem. 193, 265 – 275. | en_US |
dc.identifier.citedreference | Martres M. P., Baudry M. & Schwartz J.-C. ( 1975 ) Brain Res. 83, 261 – 275. | en_US |
dc.identifier.citedreference | Merril C. R., Snyder S. H. & Bradley D. F. ( 1966 ) Biochim. biophys. Acta 118, 316 – 324. | en_US |
dc.identifier.citedreference | Mezei C. ( 1975 ) Brain Res. 84, 453 – 460. | en_US |
dc.identifier.citedreference | Orr E. & Quay W. B. ( 1975 ) Endocrinology 96, 941 – 945. | en_US |
dc.identifier.citedreference | Reiner J. M. ( 1959 ) in Behavior of Enzyme Systems, p. 176. Burgess, Minneapolis MN. | en_US |
dc.identifier.citedreference | Rosengarten H. & Friedhoff A. J. ( 1976 ) Schizophrenia Bull. 2, 90 – 105. | en_US |
dc.identifier.citedreference | Saavedra J. M., Brownstein M. J. & Palkovits M. ( 1976 ) Brain Res. 118, 152 – 156. | en_US |
dc.identifier.citedreference | Saavedra J. M., Grobecker H. & Axelrod J. ( 1975 ) Science 191, 483 – 484. | en_US |
dc.identifier.citedreference | Saavedra J. M., Palkovits M., Brownstein M. J. & Axelrod J. ( 1974 ) Nature 248, 695 – 696. | en_US |
dc.identifier.citedreference | Salas C. E., Ohlsson W. G. & Sellinger O. Z. ( 1977 ) Biochem. Biophys. Res. Commun. 76, 1107 – 1115. | en_US |
dc.identifier.citedreference | Schatz R. A., Harris R. & Sellinger O. Z. ( 1976 ) Neurochem. Res. 1, 53 – 63. | en_US |
dc.identifier.citedreference | Schatz R. A. & Sellinger O. Z. ( 1975a ) J. Neurochem. 25, 73 – 78. | en_US |
dc.identifier.citedreference | Schatz R. A. & Sellinger O. Z. ( 1975b ) J. Neurochem. 24, 63 – 66. | en_US |
dc.identifier.citedreference | Schatz R. A. & Sellinger O. Z. ( 1977 ) Pharmacologist 19, 187. | en_US |
dc.identifier.citedreference | Schatz R. A., Vunnam C. R. & Sellinger O. Z. ( 1977 ) Neurochem. Res. 2, 27 – 38. | en_US |
dc.identifier.citedreference | Schayer R. W. & Reilly M. A. ( 1975 ) Agents & Actions 5, 231 – 235. | en_US |
dc.identifier.citedreference | Sellinger O. Z., Schatz R. A., Ashcraft E. K. & Ohlsson W. G. ( 1976 ) Trans. Am. Soc. Neurochem. 7, 237. | en_US |
dc.identifier.citedreference | Snyder S. H. & Axelrod J. ( 1965 ) Biochim. biophys. Acta 111, 416 – 421. | en_US |
dc.identifier.citedreference | Suriyachan D. & Thithapandha A. ( 1972 ) Biochem. biophys. Res. Commun. 48, 1199 – 1207. | en_US |
dc.identifier.citedreference | Taylor K. M. ( 1973 ) Biochem. Pharmac. 22, 2775 – 2776. | en_US |
dc.identifier.citedreference | Taylor K. M. & Snyder S. H. ( 1972 ) Molec. Pharmac. 8, 300 – 310. | en_US |
dc.identifier.citedreference | Vogel W. H., Lewis L. E. & Boehme D. M. ( 1976 ) Brain Res. 115, 357 – 359. | en_US |
dc.identifier.citedreference | White H. L. & Wu J. C. ( 1975 ) Biochem. J., Lond. 145, 135 – 143. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.