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Admixture in the Hispanics of the San Luis Valley, Colorado, and its implications for complex trait gene mapping
dc.contributor.authorBonilla, C.en_US
dc.contributor.authorParra, E. J.en_US
dc.contributor.authorPfaff, Carrie Lynnen_US
dc.contributor.authorDios, S.en_US
dc.contributor.authorMarshall, J. A.en_US
dc.contributor.authorHamman, R. F.en_US
dc.contributor.authorFerrell, Robert E.en_US
dc.contributor.authorHoggart, C. L.en_US
dc.contributor.authorMcKeigue, P. M.en_US
dc.contributor.authorShriver, M. D.en_US
dc.date.accessioned2010-04-01T15:27:25Z
dc.date.available2010-04-01T15:27:25Z
dc.date.issued2004-03en_US
dc.identifier.citationBonilla, C.; Parra, E. J.; Pfaff, C. L.; Dios, S.; Marshall, J. A.; Hamman, R. F.; Ferrell, R. E.; Hoggart, C. L.; McKeigue, P. M.; Shriver, M. D. (2004). "Admixture in the Hispanics of the San Luis Valley, Colorado, and its implications for complex trait gene mapping." Annals of Human Genetics 68(2): 139-153. <http://hdl.handle.net/2027.42/65937>en_US
dc.identifier.issn0003-4800en_US
dc.identifier.issn1469-1809en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65937
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15008793&dopt=citationen_US
dc.description.abstractHispanic populations are a valuable resource that can and should facilitate the identification of complex trait genes by means of admixture mapping (AM). In this paper we focus on a particular Hispanic population living in the San Luis Valley (SLV) in Southern Colorado.We used a set of 22 Ancestry Informative Markers (AIMs) to describe the admixture process and dynamics in this population. AIMs are defined as genetic markers that exhibit allele frequency differences between parental populations ≥30%, and are more informative for studying admixed populations than random markers. The ancestral proportions of the SLV Hispanic population are estimated as 62.7 ± 2.1% European, 34.1 ± 1.9% Native American and 3.2 ± 1.5% West African. We also estimated the ancestral proportions of individuals using these AIMs. Population structure was demonstrated by the excess association of unlinked markers, the correlation between estimates of admixture based on unlinked marker sets, and by a highly significant correlation between individual Native American ancestry and skin pigmentation (R 2 = 0.082, p < 0.001). We discuss the implications of these findings in disease gene mapping efforts.en_US
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dc.publisherBlackwell Science Ltden_US
dc.rights2004 University College Londonen_US
dc.titleAdmixture in the Hispanics of the San Luis Valley, Colorado, and its implications for complex trait gene mappingen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumHuman Genetics Department, The University of Michigan, Ann Arbor, MI 48109-0618, USAen_US
dc.contributor.affiliationotherNational Human Genome Center, Howard University, Washington, DC 20060, USAen_US
dc.contributor.affiliationotherDepartment of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canadaen_US
dc.contributor.affiliationotherDepartment of Anthropology, The Pennsylvania State University, University Park, PA 16802, USAen_US
dc.contributor.affiliationotherDepartment of Preventive Medicine and Biometrics, University of Colorado School of Medicine, Denver, CO 80262, USAen_US
dc.contributor.affiliationotherDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USAen_US
dc.contributor.affiliationotherDepartment of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London WC1E7HT, UKen_US
dc.identifier.pmid15008793en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65937/1/j.1529-8817.2003.00084.x.pdf
dc.identifier.doi10.1046/j.1529-8817.2003.00084.xen_US
dc.identifier.sourceAnnals of Human Geneticsen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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