A Sequential Stratification Method for Estimating the Effect of a Time-Dependent Experimental Treatment in Observational Studies
dc.contributor.author | Schaubel, Douglas E. | en_US |
dc.contributor.author | Wolfe, Robert A. | en_US |
dc.contributor.author | Port, Friedrich K. | en_US |
dc.date.accessioned | 2010-04-01T15:31:37Z | |
dc.date.available | 2010-04-01T15:31:37Z | |
dc.date.issued | 2006-09 | en_US |
dc.identifier.citation | Schaubel, Douglas E.; Wolfe, Robert A.; Port, Friedrich K. (2006). "A Sequential Stratification Method for Estimating the Effect of a Time-Dependent Experimental Treatment in Observational Studies." Biometrics 62(3): 910-917. <http://hdl.handle.net/2027.42/66010> | en_US |
dc.identifier.issn | 0006-341X | en_US |
dc.identifier.issn | 1541-0420 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/66010 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16984335&dopt=citation | en_US |
dc.description.abstract | Survival analysis is often used to compare experimental and conventional treatments. In observational studies, the therapy may change during follow-up and such crossovers can be summarized by time-dependent covariates. Given the ever-increasing donor organ shortage, higher-risk kidneys from expanded criterion donors (ECD) are being transplanted. Transplant candidates can choose whether to accept an ECD organ (experimental therapy), or to remain on dialysis and wait for a possible non-ECD transplant later (conventional therapy). A three-group time-dependent analysis of such data involves estimating parameters corresponding to two time-dependent indicator covariates representing ECD transplant and non-ECD transplant, each compared to remaining on dialysis on the waitlist. However, the ECD hazard ratio estimated by this time-dependent analysis fails to account for the fact that patients who forego an ECD transplant are not destined to remain on dialysis forever, but could subsequently receive a non-ECD transplant. We propose a novel method of estimating the survival benefit of ECD transplantation relative to conventional therapy (waitlist with possible subsequent non-ECD transplant). Compared to the time-dependent analysis, the proposed method more accurately characterizes the data structure and yields a more direct estimate of the relative outcome with an ECD transplant. | en_US |
dc.format.extent | 301471 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Inc | en_US |
dc.rights | 2006, The International Biometric Society | en_US |
dc.subject.other | Cohort Study | en_US |
dc.subject.other | Failure Time Data | en_US |
dc.subject.other | Matching | en_US |
dc.subject.other | Proportional Hazards Model | en_US |
dc.subject.other | Risk Set | en_US |
dc.subject.other | Survival Analysis | en_US |
dc.title | A Sequential Stratification Method for Estimating the Effect of a Time-Dependent Experimental Treatment in Observational Studies | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Mathematics | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109-2029, U.S.A. | en_US |
dc.contributor.affiliationum | University Renal Research and Education Association, Ann Arbor, Michigan 48103, U.S.A. | en_US |
dc.identifier.pmid | 16984335 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/66010/1/j.1541-0420.2006.00527.x.pdf | |
dc.identifier.doi | 10.1111/j.1541-0420.2006.00527.x | en_US |
dc.identifier.source | Biometrics | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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