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The Relationship Between Arachidonic Acid Release and Catecholamine Secretion from Cultured Bovine Adrenal Chromaffin Cells
dc.contributor.authorFrye, Roy A.en_US
dc.contributor.authorHolz, Ronald W.en_US
dc.date.accessioned2010-04-01T15:34:56Z
dc.date.available2010-04-01T15:34:56Z
dc.date.issued1984-07en_US
dc.identifier.citationFrye, Roy A.; Holz, Ronald W. (1984). "The Relationship Between Arachidonic Acid Release and Catecholamine Secretion from Cultured Bovine Adrenal Chromaffin Cells." Journal of Neurochemistry 43(1): 146-150. <http://hdl.handle.net/2027.42/66068>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/66068
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6427410&dopt=citationen_US
dc.description.abstractIncreased arachidonic acid release occurred during activation of catecholamine secretion from cul- tured bovine adrenal medullary chromaffin cells. The nicotinic agonist l,l-dimethyl-4-phenylpiperazinium (DMPP) caused an increased release of prcincubated [ 3 H]arachidonic acid over a time course which corre- sponded to the stimulation of catecholamine secretion. Like catecholamine secretion, the DMPP-induced [ 3 H]arachidonic acid release was calcium-dependent and was blocked by the nicotinic antagonist mecamylamine. Depolarization by elevated K + , which induced catechol amine secretion, also stimulated arachidonic acid release. Because arachidonic acid release from cells probably re- sults from phospholipase A 2 activity, our findings indicate that phospholipase A 2 may be activated in chromaffin cells during secretion.en_US
dc.format.extent475972 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1984 International Society for Neurochemistryen_US
dc.subject.otherArachidonic Aciden_US
dc.subject.otherCatecholamine Secretionen_US
dc.subject.otherChromaffin Cellsen_US
dc.subject.otherPhospho-lipase a 2en_US
dc.titleThe Relationship Between Arachidonic Acid Release and Catecholamine Secretion from Cultured Bovine Adrenal Chromaffin Cellsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, U.S.A.en_US
dc.identifier.pmid6427410en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/66068/1/j.1471-4159.1984.tb06690.x.pdf
dc.identifier.doi10.1111/j.1471-4159.1984.tb06690.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
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dc.identifier.citedreferenceFrye R. A., and Holz R. W. ( 1983 ) Phospholipase A 2 inhibitors block catecholamine secretion and calcium uptake in cul- tured bovine adrenal medullary cells. Mol. Pharmacol. 23, 547 – 550.en_US
dc.identifier.citedreferenceHolz R. W., Senter R. A., and Frye R. A. ( 1982 ) Relationship between Ca 2+ uptake and catecholamine secretion in pri- mary dissociated cultures of adrenal medulla. J. Neurochem. 39, 635 – 646.en_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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