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Cladistic analysis of the apolipoprotein AI-CIH-AIV gene cluster using a healthy French Canadian sample. I. Haploid analysis

dc.contributor.authorHaviland, Martha B.en_US
dc.contributor.authorKessling, A. M.en_US
dc.contributor.authorDavignon, Jeanen_US
dc.contributor.authorSing, Charles F.en_US
dc.date.accessioned2010-04-01T15:35:02Z
dc.date.available2010-04-01T15:35:02Z
dc.date.issued1995-04en_US
dc.identifier.citationHAVILAND, M. B.; KESSLING, A. M.; DAVIGNON, J.; SING, C. F. (1995). "Cladistic analysis of the apolipoprotein AI-CIH-AIV gene cluster using a healthy French Canadian sample. I. Haploid analysis." Annals of Human Genetics 59(2): 211-231. <http://hdl.handle.net/2027.42/66070>en_US
dc.identifier.issn0003-4800en_US
dc.identifier.issn1469-1809en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/66070
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7625767&dopt=citationen_US
dc.description.abstractA cladistic analysis was carried out to identify haplotypes hypothesized to differ for functional DNA sequence variations within the apolipoprotein (apo) AI-CIII-AIV gene cluster that affect plasma lipid, lipoprotein and apolipoprotein levels. A sample of unrelated healthy French Canadians was studied. First, a cladogram of the observed apo AI-CIII-AIV haplotypes was estimated. Then this cladogram was used to define a statistical analysis of the association between haplotype variation and variation in plasma lipid, lipoprotein and apolipoprotein levels. Three haplotypes were identified which were associated with small (5–12% of the total sum of squares) pleiotropic effects on plasma lipid, lipoprotein and apolipoprotein traits and these effects were context, i.e. gender, dependent.en_US
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1995 University College London and Blackwell Publishing Ltden_US
dc.titleCladistic analysis of the apolipoprotein AI-CIH-AIV gene cluster using a healthy French Canadian sample. I. Haploid analysisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109-0618, USAen_US
dc.contributor.affiliationotherDepartments of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London, Englanden_US
dc.contributor.affiliationotherHyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal (QC), Canadaen_US
dc.identifier.pmid7625767en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/66070/1/j.1469-1809.1995.tb00742.x.pdf
dc.identifier.doi10.1111/j.1469-1809.1995.tb00742.xen_US
dc.identifier.sourceAnnals of Human Geneticsen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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