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Biological foundation for periodontitis as a potential risk factor for atherosclerosis
dc.contributor.authorChun, Yong-Hee P.en_US
dc.contributor.authorChun, Kyoung-Ryul J.en_US
dc.contributor.authorOlguin, De'Avlinen_US
dc.contributor.authorWang, Hom-Layen_US
dc.date.accessioned2010-04-01T15:37:18Z
dc.date.available2010-04-01T15:37:18Z
dc.date.issued2005-02en_US
dc.identifier.citationChun, Yong-Hee P.; Chun, Kyoung-Ryul J.; Olguin, De'Avlin; Wang, Hom-Lay (2005). "Biological foundation for periodontitis as a potential risk factor for atherosclerosis." Journal of Periodontal Research 40(1): 87-95. <http://hdl.handle.net/2027.42/66109>en_US
dc.identifier.issn0022-3484en_US
dc.identifier.issn1600-0765en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/66109
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15613084&dopt=citationen_US
dc.description.abstractLinks between periodontal diseases and systemic diseases have been well documented by epidemiological studies. Recently, research has shifted to elucidating the biologic mechanism for a causal relationship. One focus of interest is atherosclerosis, the underlying event of cardiovascular diseases due to its serious health impact. However, it is still not clear whether periodontopathic pathogens are truly etiologic agents or ubiquitous bystanders. This article reviews the current understanding about the molecular biological interactions between periodontal disease and atherosclerosis and the biological plausibility of periodontitis as a potential risk factor for cardiovascular disease. Materials and methods:  The current literature regarding periodontal diseases and atherosclerosis and coronary vascular disease was searched using the Medline and PubMed databases. Results:  In vitro experiments and animal models are appropriate tools to investigate the biological interactions between periodontal disease and atherosclerosis at the cell molecular level. The concepts linking both pathologies refer to inflammatory response, immune responses, and hemostasis. In particular, Porphyromonas gingivalis appears to have unique, versatile pathogenic properties. Whether or not these findings from isolated cells or animal models are applicable in humans with genetic and environmental variations is yet to be determined. Likewise, the benefit from periodontal therapy on the development of atherosclerosis is unclear. Approaches targeting inflammatory and immune responses of periodontitis and atherosclerosis simultaneously are very intriguing. Conclusion:  An emerging concept suggests that a pathogenic burden from different sources might overcome an individual threshold culminating in clinical sequela. P. gingivalis contributes directly and indirectly to atherosclerosis.en_US
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dc.publisherMunksgaard International Publishersen_US
dc.publisherBlackwell Publishing Ltden_US
dc.rights2004 Blackwell Munksgaard Ltden_US
dc.subject.otherAtherosclerosisen_US
dc.subject.otherBacteremiaen_US
dc.subject.otherCardiovascular Diseaseen_US
dc.subject.otherPeriodontal Diseaseen_US
dc.subject.otherPorphyromonas Gingivalisen_US
dc.titleBiological foundation for periodontitis as a potential risk factor for atherosclerosisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelDentistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum* Department of Periodontics/Prevention/Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationother† AK St. Georg, Medical Clinic II, Department of Cardiology, Hamburg, Germanyen_US
dc.identifier.pmid15613084en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/66109/1/j.1600-0765.2004.00771.x.pdf
dc.identifier.doi10.1111/j.1600-0765.2004.00771.xen_US
dc.identifier.sourceJournal of Periodontal Researchen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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