Measurement of Receptor-Activated Phosphoinositide Turnover in Rat Brain: Nonequivalence of Inositol Phosphate and CDP-Diacylglycerol Formation
dc.contributor.author | Heacock, Anne M. | en_US |
dc.contributor.author | Seguin, Edward B. | en_US |
dc.contributor.author | Agranoff, Bernard W. | en_US |
dc.date.accessioned | 2010-04-01T15:38:51Z | |
dc.date.available | 2010-04-01T15:38:51Z | |
dc.date.issued | 1993-03 | en_US |
dc.identifier.citation | Heacock, Anne M.; Seguin, Edward B.; Agranoff, Bernard W. (1993). "Measurement of Receptor-Activated Phosphoinositide Turnover in Rat Brain: Nonequivalence of Inositol Phosphate and CDP-Diacylglycerol Formation." Journal of Neurochemistry 60(3): 1087-1092. <http://hdl.handle.net/2027.42/66135> | en_US |
dc.identifier.issn | 0022-3042 | en_US |
dc.identifier.issn | 1471-4159 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/66135 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8382261&dopt=citation | en_US |
dc.description.abstract | Two methods for the measurement of receptor-activated phosphoinositide turnover were evaluated for their degree of correspondence in slices of rat brain; they involved the Li + -dependent accumulations of either [ 3 H]-inositol-labeled inositol phosphates or [ 3 H]cytidine-labeled CDP-diacylglycerol. In contrast to the expectation that the ratio of these two responses would remain approximately constant, varying degrees of correspondence were obtained. The two extremes are exemplified by carbachol, which elicited large increases in both inositol phosphate and CDP-diacylglycerol labeling, and endothelin, which gave a robust inositol phosphate response with little or no accumulation of 3 H-CDP-diacylglycerol. No instance of the presence of the latter response in the absence of 3 H-inositol phosphate accumulation was observed. Measurement of 3 H-CDP-diacylglycerol accumulation thus may add additional insight into the regulation of phosphoinositide turnover and the complex actions of Li + . | en_US |
dc.format.extent | 659725 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1993 International Society for Neurochemistry | en_US |
dc.subject.other | Phosphoinositide Turnover | en_US |
dc.subject.other | Inositol Phosphate | en_US |
dc.subject.other | CDP-diacylglycerol | en_US |
dc.subject.other | Rat Brain | en_US |
dc.title | Measurement of Receptor-Activated Phosphoinositide Turnover in Rat Brain: Nonequivalence of Inositol Phosphate and CDP-Diacylglycerol Formation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neuroscience, Laboratory, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 8382261 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/66135/1/j.1471-4159.1993.tb03258.x.pdf | |
dc.identifier.doi | 10.1111/j.1471-4159.1993.tb03258.x | en_US |
dc.identifier.source | Journal of Neurochemistry | en_US |
dc.identifier.citedreference | Agranoff B. W., Bradley R. M., and Brady R. O. ( 1958 ) The enzymatic synthesis of inositol phosphatide. J. Biol. Chem. 233, 1077 – 1083. | en_US |
dc.identifier.citedreference | Allison J. H. and Stewart M. A. ( 1971 ) Reduced brain inositol in lithium-treated rats. Nature 233, 267 – 268. | en_US |
dc.identifier.citedreference | Baird J. O., Challiss A. J., and Nahorski S. R. ( 1991 ) Role for iono-tropic and metabotropic receptors in quisqualate-stimulated inositol polyphosphate accumulation in rat cerebral cortex. Mol. Pharmacol. 39, 745 – 753. | en_US |
dc.identifier.citedreference | Benjamins J. A. and Agranoff B. W. ( 1969 ) Distribution and properties of CDP-diglyceride:inositol transferase from brain. J. Neurochem. 16, 513 – 527. | en_US |
dc.identifier.citedreference | Berridge M. J., Downes C. P., and Hanley M. R. ( 1982 ) Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem. J. 206, 587 – 595. | en_US |
dc.identifier.citedreference | Berridge M. J., Downes C P., and Hanley M. R. ( 1989 ) Neural and developmental actions of lithium: a unifying hypothesis. Cell 59, 411 – 419. | en_US |
dc.identifier.citedreference | Downes C. P. and Stone M. A. ( 1986 ) Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland. Biochem. J. 234, 199 – 204. | en_US |
dc.identifier.citedreference | Eichberg J., Gates J., and Hauser G. ( 1979 ) The mechanism of modification by propranolol of the metabolism of phosphati-dyl-CMP (CDP-diacylglyceroI) and other lipids in the rat pineal gland. Biochim. Biophys. Acta 573, 90 – 106. | en_US |
dc.identifier.citedreference | Fischl A. S. and Carman G. M. ( 1983 ) Phosphatidylinositol biosynthesis in Saccharomyces cerevisiae: purification and properties of microsome-associated phosphatidylinositol synthase. J. Bacterial 154, 304 – 311. | en_US |
dc.identifier.citedreference | Fisher S. K., Figueiredo J. C, and Bartus R. T. ( 1984 ) Differential stimulation of inositol phospholipid turnover in brain by analogs of oxotremorine. J. Neurochem. 43, 1171 – 1179. | en_US |
dc.identifier.citedreference | Fisher S. K., Heacock A. M., and Agranoff B. W. ( 1992 ) Inositol lipids and signal transduction in the nervous system: an update. J. Neurochem. 58, 18 – 38. | en_US |
dc.identifier.citedreference | Geiger P. J. and Bessman S. P. ( 1972 ) Protein determination by Lowry's method in the presence of sulfhydryl reagents. Anal. Biochem. 49, 467 – 473. | en_US |
dc.identifier.citedreference | Ghalayini A. and Eichberg J. ( 1985 ) Purification of phosphatidylinositol synthetase from rat brain by CDP-diacylglycerol affinity chromatography and properties of the purified enzyme. J. Neurochem. 44, 175 – 182. | en_US |
dc.identifier.citedreference | Godfrey P. P. ( 1989 ) Potentiation by lithium of CMP-phosphati-date formation in carbachol-stimulated rat cerebral-cortical slices and its reversal by myo-inositol. Biochem. J. 258, 621 – 624. | en_US |
dc.identifier.citedreference | Godfrey P. P. and Taghavi Z. ( 1990 ) The effect of non-NMDA antagonists and phorbol esters on excitatory amino acid stimulated inositol phosphate formation in rat cerebral cortex. Neurochem. Int. 16, 65 – 72. | en_US |
dc.identifier.citedreference | Hauser G. and Eichberg J. ( 1975 ) Identification of cytidine diphos-phate-diglyceride in the pineal gland of the rat and its accumulation in the presence of DL-propranolol. J. Biol. Chem. 250, 105 – 112. | en_US |
dc.identifier.citedreference | Heacock A. M., Fisher S. K., and Agranoff B. W. ( 1987 ) Enhanced coupling of neonatal muscarinic receptors in rat brain to phos-phoinositide turnover. J. Neurochem. 48, 1904 – 1911. | en_US |
dc.identifier.citedreference | HonorÉ T., Davies S. N., Drejer J., Fletcher E. J., Jacobsen P., Lodge D., and Nielsen F. E. ( 1988 ) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241, 701 – 703. | en_US |
dc.identifier.citedreference | Hwang P. M., Bredt D. S., and Snyder S. H. ( 1990 ) Autoradio-graphic imaging of phosphoinositide turnover in the brain. Science 249, 802 – 804. | en_US |
dc.identifier.citedreference | Imai A. and Gershengorn M. C. ( 1987 ) Independent phosphatidyl-inositol synthesis in pituitary plasma membrane and endoplas-mic reticulum. Nature 325, 726 – 728. | en_US |
dc.identifier.citedreference | Kanoh H., Yamada K., and Sakane F. ( 1990 ) Diacylglycerol ki-nase: a key modulator of signal transduction. Trends Biochem Sci. 15, 47 – 50. | en_US |
dc.identifier.citedreference | Kennedy E. D., Challiss R. A. J., Ragan C. I., and Nahorski S. R. ( 1990 ) Reduced inositol polyphosphate accumulation and ino-sitol supply induced by lithium in stimulated cerebral cortex slices. Biochem. J. 267, 781 – 786. | en_US |
dc.identifier.citedreference | Mount J. N. and Laker M. F. ( 1981 ) Estimation of sugar alcohols by gas-liquid chromatography using a modified acetylation procedure. J. Chromatogr. 226, 191 – 197. | en_US |
dc.identifier.citedreference | Nicoletti F., ladarola M. J., Wroblewski J. T., and Costa E ( 1986 ) Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with Α 1 adrenoreceptors. Proc. Natl. Acad. Sci. USA 83 1931 – 1935. | en_US |
dc.identifier.citedreference | Paulus H. and Kennedy E. P. ( 1960 ) The enzymatic synthesis of inositol monophosphatide. J. Biol. Ghent. 235, 1303 – 1311. | en_US |
dc.identifier.citedreference | Recasens M., Guiramand J., Nourigat A., Sassetti I., and Devillieis G. ( 1988 ) A new quisqualate receptor subtype (sAA 2 ) responsible for the glutamate-induced inositol phosphate formation in rat brain synaptoneurosomes. Neurochem. Int. 13, 463 – 467. | en_US |
dc.identifier.citedreference | Schoepp D. D. and Hillman C. C. Jr. ( 1990 ) Developmental and pharmacological characterization of quisqualate, ibotenate, and trans-1-amino-1,3-cyclopentanedicarboxylic acid stimulations of phosphoinositide hydrolysis in rat cortical brain slices. Biogenic Amines 7, 331 – 340. | en_US |
dc.identifier.citedreference | Sherman W. R., Packman P. M., Laird M. H., and Boshans, R L. ( 1977 ) Measurement of wyo-inositol in single cells and defined areas of the nervous system by selected ion monitoring. Anal Biochem. 78, 119 – 131. | en_US |
dc.identifier.citedreference | Sherman W. R., Gish B. G., Honchar M. P., and Munsell L. Y. ( 1986 ) Effects of lithium on phosphoinositide metabolism in vivo. Fed. Proc. 45, 2639 – 2646. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.