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Biosynthesis of Triglyceride and Other Fatty Acyl Esters by Developing Rat Brain
dc.contributor.authorBishop, James E.en_US
dc.contributor.authorHajra, Amiya K.en_US
dc.date.accessioned2010-04-01T15:40:10Z
dc.date.available2010-04-01T15:40:10Z
dc.date.issued1984-10en_US
dc.identifier.citationBishop, James E.; Hajra, Amiya K. (1984). "Biosynthesis of Triglyceride and Other Fatty Acyl Esters by Developing Rat Brain." Journal of Neurochemistry 43(4): 1046-1051. <http://hdl.handle.net/2027.42/66158>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/66158
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6470705&dopt=citationen_US
dc.description.abstractThe biosynthesis of triglyceride from 1,2-diglyceride and long-chain acyl coenzyme A (CoA) was studied in developing rat brain. Diglyceride acyltransferase activity was highest in a microsomal fraction, had a neutral pH optimum, and was stimulated by MgCl 2 . Palmitoyl CoA and oleoyl CoA served equally well as acyl donors. The enzyme catalyzed the acylation of both endogenous diglyceride and several naturally occurring and synthetic exogenous diglycerides. In addition, short-chain primary and secondary alcohols were found to be acylated under these conditions. A second acylation system, active at low pH, was found to catalyze esterification of ethanol and cholesterol, but not diglyceride, with free fatty acid. These results demonstrate that brain has the capacity to acylate a wide variety of physiological and nonphysiological hydroxyl compounds.en_US
dc.format.extent811596 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1984 International Society for Neurochemistryen_US
dc.subject.otherDiglyceride Acyltransferaseen_US
dc.subject.otherEthanol Acyltransferaseen_US
dc.subject.otherTrigylcerideen_US
dc.titleBiosynthesis of Triglyceride and Other Fatty Acyl Esters by Developing Rat Brainen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumNeuroscience Laboratory, Mental Health Research Institute, and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.identifier.pmid6470705en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/66158/1/j.1471-4159.1984.tb12842.x.pdf
dc.identifier.doi10.1111/j.1471-4159.1984.tb12842.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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