View Item 

Show simple item record

Imaging the Dopamine Uptake Site with Ex Vivo [ 18 F]GBR 13119 Binding Autoradiography in Rat Brain
dc.contributor.authorCiliax, Brian J.en_US
dc.contributor.authorKilbourn, Michael R.en_US
dc.contributor.authorHaka, Michael S.en_US
dc.contributor.authorPenney, John B.en_US
dc.date.accessioned2010-04-01T15:43:08Z
dc.date.available2010-04-01T15:43:08Z
dc.date.issued1990-08en_US
dc.identifier.citationCiliax, Brian J.; Kilbourn, Michael R.; Haka, Michael S.; Penney, John B. (1990). "Imaging the Dopamine Uptake Site with Ex Vivo [ 18 F]GBR 13119 Binding Autoradiography in Rat Brain." Journal of Neurochemistry 55(2): 619-623. <http://hdl.handle.net/2027.42/66209>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/66209
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2115074&dopt=citationen_US
dc.description.abstractWe studied the binding of [ 18 F]GBR 13119 {1-[[(4-[ 18 F]fluorophenyl) (phenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine} to rat brain with autoradiography after intravenous injection. The rank order of binding was dorsal striatum > nucleus accumbens = olfactory tubercle > sub-stantia nigra = ventral tegmental area > other areas. Binding was blocked by prior injection of dopamine uptake blockers but not by injection of dopamine receptor antagonists or drugs that bind to the dialkylpiperazine site. Unilateral 6-hydroxy dopamine lesions of dopamine neurons caused a marked decrease in striatal and nigral binding on the side of the lesion. We conclude that intravenous injection of [ 18 F]GBR 13119 provides a useful marker of presynaptic dopamine uptake sites.en_US
dc.format.extent1041663 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1990 International Society for Neurochemistryen_US
dc.subject.otherDopamine Uptakeen_US
dc.subject.other[ 18 F]GBR 13119–6-Hydroxydopamine Lesionsen_US
dc.subject.otherPositron Emission Tomography Scanning.en_US
dc.titleImaging the Dopamine Uptake Site with Ex Vivo [ 18 F]GBR 13119 Binding Autoradiography in Rat Brainen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Nuclear Medicine, University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.contributor.affiliationotherDepartment of Neurologyen_US
dc.identifier.pmid2115074en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/66209/1/j.1471-4159.1990.tb04178.x.pdf
dc.identifier.doi10.1111/j.1471-4159.1990.tb04178.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
dc.identifier.citedreferenceAndersen P. H. ( 1987 ) Biochemical and pharmacological characterization of [ 3 H]GBR 12935 binding in vitro to rat striatal membranes: labeling of the dopamine uptake complex. J. Neurochem. 48, 1887 – 1896.en_US
dc.identifier.citedreferenceAndersen P. H., Jansen J. A., and Nielsen E. B. ( 1987 ) [ 3 H]GBR 12935 binding in vivo in mouse brain: labelling of a piperazine accepter site. Eur. J. Pharmacol. 144, 1 – 6.en_US
dc.identifier.citedreferenceArnett C. D., Shiue C.-Y., Wolf A. P., Fowler J. S., Logan J., and Watanabe M. ( 1985 ) Comparison of three 18 F-labeled butyrophenone neuroleptic drugs in the baboon using positron emission tomography. J. Neurochcm. 44, 835 – 844.en_US
dc.identifier.citedreferenceBenmansour S., Bonnet J.-J., Protais P., and Costentin J. ( 1987 ) Sodium independence of the binding of [ 3 H]GBR 12783 and other dopamine uptake inhibitors to the dopamine uptake complex. Neurosci. Lett. 11, 97 – 102.en_US
dc.identifier.citedreferenceBonnet J.-J. and Costentin J. ( 1986 ) GBR 12783, a potent and selective inhibitor of dopamine uptake: biochemical studies in vivo and ex vivo. Eur. J. Pharmacol. 121, 199 – 209.en_US
dc.identifier.citedreferenceBonnet J.-J., Protais P., Chagraoui A., and Costentin J. ( 1986 ) High affinity [ 3 H]GBR 12783 binding to a specific site associated with the neuronal dopamine uptake complex in the central nervous system. Eur. J. Pharmacol. 126, 211 – 222.en_US
dc.identifier.citedreferenceCalne D. B., Langston J. W., Martin W. R. W., Stoessi A. J., Ruth T. J., Adam M. J., Pate B. D., and Schulzer M. ( 1985 ) Positron emission tomography after MPTP: observations relating to the cause of Parkinson's disease. Nature 317, 246 – 248.en_US
dc.identifier.citedreferenceChagraoui A., Bonnet J., Protais P., and Costentin J. ( 1987 ) In vivo binding of [ 3 H]GBR 12783, a selective dopamine uptake inhibitor in mouse striatum. Neurosci. Lett. 78, 175 – 179.en_US
dc.identifier.citedreferenceCiliax B. J., Penney J. B., and Young A. B. ( 1986 ) In vivo [ 3 H]flunitrazepam binding: imaging of receptor regulation. J. Pharmacol. Exp. Ther. 238, 749 – 757.en_US
dc.identifier.citedreferenceCumming P., Boyes B. E., Martin W. R. W., Adam M., Grierson J., Ruth T., and McGeer E. G. ( 1987 ) The metabolism of [ 18 F]6-fluoro-l-3,4-dihydroxyphenylalanine in the hooded rat. J. Neurochem. 48, 601 – 608.en_US
dc.identifier.citedreferenceDawson T. W., Gehlhert D. R., and Wamsley J. K. ( 1986 ) Quantitative autoradiographic localization of the dopamine transport complex in the rat brain: use of a highly selective radioligand, [ 3 H]GBR 12935. Eur. J. Pharmacol. 126, 171 – 173.en_US
dc.identifier.citedreferenceFarde L., Hall H., Ehrin E., and Sedvall G. ( 1986 ) Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET. Science 231, 258 – 261.en_US
dc.identifier.citedreferenceFilloux F., Hunt M. A., and Wamsley J. K. ( 1989 ) Localization of the dopamine uptake complex using [ 3 H]N-[1-(2-benzo-(b)thiophenyl)cyclohexyl]piperidine ([ 3 H]BTCP) in rat brain. Neurosci. Lett. 100, 105 – 110.en_US
dc.identifier.citedreferenceFirnau G., Sood S., Chirakal R., Nahmias C., and Garnett E. S. ( 1987 ) Cerebral metabolism of 6-[ 18 F]fluoro-l-3,4-dihydroxyphenylalanine in the primate. J. Neurochem. 48, 1077 – 1082.en_US
dc.identifier.citedreferenceGarnett E. S., Firnau G., and Nahmias C. ( 1983 ) Dopamine visualized in the basal ganglia of living man. Nature 305, 137 – 138.en_US
dc.identifier.citedreferenceHagglund J., Aquilonius S. M., Eckernas S. A., Hartvig P., Lundquist H., Gullberg P., and Langstrom B. ( 1987 ) Dopamine receptor properties in Parkinson's disease and Huntington's chorea evaluated by positron emission tomography using 11 C-N-methylspiperone. Acta Neurol. Scand. 75, 87 – 94.en_US
dc.identifier.citedreferenceHoehn M. M., Crowley T. J., and Rutledge C. O. ( 1976 ) Dopamine correlates of neurological and psychological status in untreated parkinsonism. J. Neurol. Neurosurg. Psychiatry 39, 941 – 951.en_US
dc.identifier.citedreferenceHornykiewicz O. and Kish S. ( 1987 ) Biochemical pathophysiology of Parkinson's disease, in Advances in Neurology, Vol. 45: Parkinson's Disease ( Yahr M. D. and Bergmann K. J., eds ), pp. 19 – 34. Raven Press, New York.en_US
dc.identifier.citedreferenceJanowsky A., Berger P., Vocci F., Labarca R., Skolnick P., and Paul S. M. ( 1986 ) Characterization of sodium-dependent [ 3 H]GBR-12935 binding in brain: a radioligand for selective labelling of the dopamine transport complex. J. Neurochem. 46, 1272 – 1276.en_US
dc.identifier.citedreferenceJanowsky A., Vocci F., Berger P., Angel I., Zelnik N., Kleinman J. E., Skolnick P., and Paul S. M. ( 1987 ) [ 3 H]GBR-12935 binding to the dopamine transporter is decreased in the caudate nucleus in Parkinson's disease. J. Neurochem. 49, 617 – 621.en_US
dc.identifier.citedreferenceKilbourn M. R. ( 1988 ) In vivo binding of [ 18 F]GBR 13119 to the brain dopamine uptake system. Life Sci. 42, 1347 – 1353.en_US
dc.identifier.citedreferenceKilbourn M. R. and Haka M. S. ( 1988 ) Synthesis of [ 18 F]GBR 13119, a presynaptic dopamine uptake blocker. Int. J. Rad. Appl. Instrum. [B] 39, 441 – 444.en_US
dc.identifier.citedreferenceKilbourn M. R., Carey J. E., Koeppe R. A., Haka M. S., Hutchins G. D., Sherman P. S., and Kuhl D. E. ( 1989a ) Biodistribution, dosimetry, metabolism and monkey PET studies of [ 18 F]GBR 13119. Imaging the dopamine uptake system in vivo. Nucl. Med. Biol. 16, 569 – 576.en_US
dc.identifier.citedreferenceKilbourn M. R., Haka M. S., Mulholland G. K., Sherman P. S., and Pisani J. ( 1989b ) Regional brain distribution of [ 18 F]GBR 13119, a dopamine uptake inhibitor, in CD-1 and C57BL6 mice. Eur. J. Pharmacol. 166, 331 – 334.en_US
dc.identifier.citedreferenceLeenders K. L., Palmer A. J., Quinn N., Clark J. C., Firnau G., Garnett E. S., Nahmias C., Jones T., and Marsden C. D. ( 1986 ) Brain dopamine metabolism in patients with Parkinson's disease measured with positron tomography. J. Neurol. Neurosurg. Psychiatry 49, 853 – 860.en_US
dc.identifier.citedreferenceMelega W. P., Perlmutter M. M., Luxen A., Nissenson C. H. K., Grafton S. T., Huang S.-C., Phelps M. E., and Barrio J. R. ( 1989 ) 4-[ 18 F]Fluoro-l-m-tyrosine: an l-3,4-dihydroxyphenylalanine analog for probing presynaptic dopaminergic function with positron emission tomography. J. Neurochem. 53, 311 – 314.en_US
dc.identifier.citedreferenceOlds J. L., Frey K. A., Ehrenkaufer R. L., and Agranoff B. W. ( 1985 ) A sequential double label autoradiographic method that quantifies altered rates of regional glucose metabolism. Brain Res. 361, 217 – 224.en_US
dc.identifier.citedreferencePan H. S., Penney J. B., and Young A. B. ( 1985 ) GABA and benzodiazepine receptor changes induced by unilateral 6-hydroxydopamine lesions of the medial forebrain bundle. J. Neurochem. 45, 1396 – 1404.en_US
dc.identifier.citedreferencePenney J. B. and Young A. B. ( 1986 ) Striatal inhomogeneities and basal ganglia function. Mov. Disord. 1, 3 – 15.en_US
dc.identifier.citedreferencePerlmutter J. S., Larson K. B., Raichle M. E., Markham J., Mintun M. A., Kilbourn M. R., and Welch M. J. ( 1986 ) Strategies for in vivo measurement of receptor binding using positron emission tomography. J. Cereb. Blood Flow Metab. 6, 154 – 169.en_US
dc.identifier.citedreferenceRaiteri M., Cerrito F., Cervoni A. M., and Levi G. ( 1979 ) Dopamine can be released by two mechanisms differentially affected by the dopamine transport inhibitor nomifensine. J. Pharmacol. Exp. Ther. 208, 195 – 202.en_US
dc.identifier.citedreferenceRutgers A. W. F., Lakke J. P. W. F., Paans A. M. J., Vaalburg W., and Korf J. ( 1987 ) Tracing of dopamine receptors in hemipar-kinsonism with positron emission tomography (PET). J. Neurol. Sci. 80, 237 – 248.en_US
dc.identifier.citedreferenceSchacht V. and Heptner W. ( 1974 ) Effect of nomifensine (HOE 984), a new antidepressant, on uptake of noradrenaline and serotonin and on release of noradrenaline in rat brain synaptosomes. Biochem. Pharmacol. 23, 3413 – 3422.en_US
dc.identifier.citedreferenceSeeman P. ( 1987 ) Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse 1, 133 – 152.en_US
dc.identifier.citedreferenceTarsy D. and Baldessarini R. J. ( 1984 ) Tardive dyskinesia. Annu. Rev. Med. 35, 605 – 623.en_US
dc.identifier.citedreferenceTedroff J., Aquilonius S. M., Hartvig P., Lundqvist H., Gee A. G., Uhlin J., and Langstrom B. ( 1988 ) Monoamine re-uptake sites in the human brain evaluated in vivo by means of 11 C-nomifensine and positron emission tomography: the effects of age and Parkinson's disease. Acta Neurol. Scand. 11, 192 – 201.en_US
dc.identifier.citedreferenceUngerstedt U. ( 1971 ) Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigrostriatal dopamine system in the rat brain. Acta Physiol. Scand. 197 [ Suppl. 367 ], 69 – 93.en_US
dc.identifier.citedreferenceVan der Zee P., Koger H. S., Gootjes J., and Hespe W. ( 1980 ) Aryl 1,4-dialk(en)ylpiperazines as selective and very potent inhibitors of dopamine uptake. Eur. J. Med. Chem. 15, 363 – 370.en_US
dc.identifier.citedreferenceWagner H. N., Burns H. D., Dannals R. F., Wong D. F., Langstrom B., Duelfer T., Frost J. J., Ravert H. T., Links J. M., Rosenbloom S. B., Lukas S. E., Kramer A. V., and Kuhar M. J. ( 1983 ) Imaging dopamine receptors in the human brain by positron tomography. Science 221, 1264 – 1266.en_US
dc.identifier.citedreferenceWong D. F., Wagner H. N., Dannals R. F., Links J. M., Frost J. J., Ravert H. T., Wilson A. A., Rosenbaum A. E., Gjedde A., Douglass K. H., Petronis J. D., Folstein M. F., Tuong J. K. T., Burns H. D., and Kuhar M.J. ( 1984 ) Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain. Science 226, 1393 – 1395.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
j.1471-4159.1990.tb04178.x.pdf
Size:
1017.KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.