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Concentrations of Homovanillic Acid and 5-Hydroxyindoleacetic Acid in Cerebrospinal Fluid from Human Infants in the Perinatal Period
dc.contributor.authorSilverstein, Faye Sarahen_US
dc.contributor.authorDonn, Steven M.en_US
dc.contributor.authorBuchanan, Karenen_US
dc.contributor.authorJohnston, Michael V.en_US
dc.date.accessioned2010-04-01T15:44:32Z
dc.date.available2010-04-01T15:44:32Z
dc.date.issued1984-12en_US
dc.identifier.citationSilverstein, Faye S.; Donn, Steven; Buchanan, Karen; Johnston, Michael V. (1984). "Concentrations of Homovanillic Acid and 5-Hydroxyindoleacetic Acid in Cerebrospinal Fluid from Human Infants in the Perinatal Period." Journal of Neurochemistry 43(6): 1769-1772. <http://hdl.handle.net/2027.42/66233>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/66233
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6208340&dopt=citationen_US
dc.description.abstractTo assess maturation of central serotonin and catecholamine pathways at birth, we measured lumbar CSF homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), stable acid metabolites of dopamine and serotonin, using HPLC with electrochemical detection. CSFs from 57 neonates (38 premature and 19 at term) and 13 infants 1–6 months old were studied. HVA levels increased with maturity (p < 0.05; ANOVA), whereas, 5-HIAA levels were similar in all these subjects. HVA/5-HIAA ratios increased markedly from 1 ± 0.12 in the most premature neonates to 1.98 ± 0.17 in the older infants (p < 0.01; t test). There were no sex differences for these values.en_US
dc.format.extent387739 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1984 International Society for Neurochemistryen_US
dc.subject.otherNeonatalen_US
dc.subject.otherDevelopmenten_US
dc.subject.otherDopamineen_US
dc.subject.otherCCSFen_US
dc.titleConcentrations of Homovanillic Acid and 5-Hydroxyindoleacetic Acid in Cerebrospinal Fluid from Human Infants in the Perinatal Perioden_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum* Drpurtment of Pedicctrics, University of Michigan Medical School, Michigun, U.S.A.en_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan Medical School, Michigun, U.S.A.en_US
dc.contributor.affiliationumCenter for Human Growth and Development, University of Michigan, Ann Arbor, Michigun, U.S.A.en_US
dc.identifier.pmid6208340en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/66233/1/j.1471-4159.1984.tb06109.x.pdf
dc.identifier.doi10.1111/j.1471-4159.1984.tb06109.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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