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Amphetamine-evoked c- fos mRNA expression in the caudate-putamen: the effects of DA and NMDA receptor antagonists vary as a function of neuronal phenotype and environmental context
dc.contributor.authorFerguson, Susan M.en_US
dc.contributor.authorNorton, Camille S.en_US
dc.contributor.authorWatson, Stanley J.en_US
dc.contributor.authorAkil, Hudaen_US
dc.contributor.authorRobinson, Terry E.en_US
dc.date.accessioned2010-04-01T15:46:48Z
dc.date.available2010-04-01T15:46:48Z
dc.date.issued2003-07en_US
dc.identifier.citationFerguson, Susan M . ; Norton, Camille S . ; Watson, Stanley J . ; Akil, Huda; Robinson, Terry E . (2003). "Amphetamine-evoked c- fos mRNA expression in the caudate-putamen: the effects of DA and NMDA receptor antagonists vary as a function of neuronal phenotype and environmental context." Journal of Neurochemistry 86(1): 33-44. <http://hdl.handle.net/2027.42/66272>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/66272
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12807422&dopt=citationen_US
dc.description.abstractDopamine (DA) and glutamate neurotransmission is thought to be critical for psychostimulant drugs to induce immediate early genes (IEGs) in the caudate-putamen (CPu). We report here, however, that the ability of DA and glutamate NMDA receptor antagonists to attenuate amphetamine-evoked c- fos mRNA expression in the CPu depends on environmental context. When given in the home cage, amphetamine induced c- fos mRNA expression predominately in preprodynorphin and preprotachykinin mRNA-containing neurons (Dyn-SP+ cells) in the CPu. In this condition, all of the D1R, D2R and NMDAR antagonists tested dose-dependently decreased c- fos expression in Dyn-SP+ cells. When given in a novel environment, amphetamine induced c- fos mRNA in both Dyn-SP+ and preproenkephalin mRNA-containing neurons (Enk+ cells). In this condition, D1R and non-selective NMDAR antagonists dose-dependently decreased c- fos expression in Dyn-SP+ cells, but neither D2R nor NR2B-selective NMDAR antagonists had no effect. Furthermore, amphetamine-evoked c- fos expression in Enk+ cells was most sensitive to DAR and NMDAR antagonism; the lowest dose of every antagonist tested significantly decreased c- fos expression only in these cells. Finally, novelty-stress also induced c- fos expression in both Dyn-SP+ and Enk+ cells, and this was relatively resistant to all but D1R antagonists. We suggest that the mechanism(s) by which amphetamine evokes c- fos expression in the CPu varies depending on the stimulus (amphetamine vs. stress), the striatal cell population engaged (Dyn-SP+ vs. Enk+ cells), and environmental context (home vs. novel cage).en_US
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dc.publisherBlackwell Science Ltden_US
dc.rights2003 International Society for Neurochemistryen_US
dc.subject.otherDopamineen_US
dc.subject.otherGlutamateen_US
dc.subject.otherImmediate Early Genesen_US
dc.subject.otherIn Situ Hybridizationen_US
dc.subject.otherStriatumen_US
dc.subject.otherRaten_US
dc.titleAmphetamine-evoked c- fos mRNA expression in the caudate-putamen: the effects of DA and NMDA receptor antagonists vary as a function of neuronal phenotype and environmental contexten_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum† Department of Psychology, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationother* Neuroscience Program,en_US
dc.contributor.affiliationother† Mental Health Research Institute anden_US
dc.identifier.pmid12807422en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/66272/1/j.1471-4159.2003.01815.x.pdf
dc.identifier.doi10.1046/j.1471-4159.2003.01815.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
dc.identifier.citedreferenceBadiani A., Camp D. M. and Robinson T. E. ( 1997 ) Enduring enhancement of amphetamine sensitization by drug-associated environmental stimuli. J. Pharmacol. Exp. Ther. 0, 787 – 794.en_US
dc.identifier.citedreferenceBadiani A., Oates M. M., Day H. E., Watson S. J., Akil H. and Robinson T. E. ( 1998 ) Amphetamine-induced behavior, dopamine release, and c-fos mRNA expression: modulation by environmental novelty. J. Neurosci. 18, 10579 – 10593.en_US
dc.identifier.citedreferenceBadiani A., Oates M. M., Day H. E., Watson S. J., Akil H. and Robinson T. E. ( 1999 ) Environmental modulation of amphetamine-induced c-fos expression in D1 versus D2 striatal neurons. Behav. Brain Res. 103, 203 – 209.en_US
dc.identifier.citedreferenceBerretta S., Robertson H. A. and Graybiel A. M. ( 1992 ) Dopamine and glutamate agonists stimulate neuron-specific expression of Fos-like protein in the striatum. J. Neurophysiol. 68, 767 – 777.en_US
dc.identifier.citedreferenceBerretta S., Robertson H. A. and Graybiel A. M. ( 1993 ) Neurochemically specialized projection neurons of the striatum respond differentially to psychomotor stimulants. Prog. Brain Res. 99, 201 – 205.en_US
dc.identifier.citedreferenceBerretta S., Parthasarathy H. B. and Graybiel A. M. ( 1997 ) Local release of GABAergic inhibition in the motor cortex induces immediate-early gene expression in indirect pathway neurons of the striatum. J. Neurosci. 17, 4752 – 4763.en_US
dc.identifier.citedreferenceBerretta S., Sachs Z. and Graybiel A. M. ( 1999 ) Cortically driven Fos induction in the striatum is amplified by local dopamine D2-class receptor blockade. Eur. J. Neurosci. 11, 4309 – 4319.en_US
dc.identifier.citedreferenceCarlsson M. and Carlsson A. ( 1990 ) Interactions between glutamatergic and monoaminergic systems within the basal ganglia – implications for schizophrenia and Parkinson's disease. Trends Neurosci. 13, 272 – 276.en_US
dc.identifier.citedreferenceCenci M. A. and Bjorklund A. ( 1993 ) Transection of corticostriatal afferents reduces amphetamine- and apomorphine-induced striatal Fos expression and turning behaviour in unilaterally 6-hydroxydopamine-lesioned rats. Eur. J. Neurosci. 5, 1062 – 1070.en_US
dc.identifier.citedreferenceCenci M. A., Kalen P., Mandel R. J., Wictorin K. and Bjorklund A. ( 1992 ) Dopaminergic transplants normalize amphetamine- and apomorphine-induced Fos expression in the 6-hydroxydopamine-lesioned striatum. Neuroscience 46, 943 – 957.en_US
dc.identifier.citedreferenceCole R. L., Konradi C., Douglass J. and Hyman S. E. ( 1995 ) Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron 14, 813 – 823.en_US
dc.identifier.citedreferenceCurran E. J. and Watson S. J. Jr ( 1995 ) Dopamine receptor mRNA expression patterns by opioid peptide cells in the nucleus accumbens of the rat: a double in situ hybridization study. J. Comp. Neurol. 361, 57 – 76.en_US
dc.identifier.citedreferenceDrago J., Gerfen C. R., Westphal H. and Steiner H. ( 1996 ) D1 dopamine receptor-deficient mouse: cocaine-induced regulation of immediate-early gene and substance P expression in the striatum. Neuroscience 74, 813 – 823.en_US
dc.identifier.citedreferenceDragunow M., Logan B. and Laverty R. ( 1991 ) 3,4-Methylenedioxymethamphetamine induces Fos-like proteins in rat basal ganglia: reversal with MK 801. Eur. J. Pharmacol. 206, 255 – 258.en_US
dc.identifier.citedreferenceDuffy R. A., Hunt M. A., Wamsley J. K. and McQuade R. D. ( 2000 ) In vivo autoradiography of [3H]SCH 39166 in rat brain: selective displacement by D1/D5 antagonists. J. Chem. Neuroanat. 19, 41 – 46.en_US
dc.identifier.citedreferenceFalk J. L. and Feingold D. A. ( 1987 ) Environmental and cultural factors in the behavioral actions of drugs, in Meltzer, H. Y., ed. Psychopharmacology: The Third Generation of Progress, pp. 1503 – 1510. Raven Press, New York.en_US
dc.identifier.citedreferenceFenu S., Carta A. and Morelli M. ( 1995 ) Intranigral injections of glutamate antagonists modulate dopamine D1-mediated turning behavior and striatal c-fos expression. J. Neural Transm. Suppl. 45, 75 – 81.en_US
dc.identifier.citedreferenceFu L. and Beckstead R. M. ( 1992 ) Cortical stimulation induces fos expression in striatal neurons. Neuroscience 46, 329 – 334.en_US
dc.identifier.citedreferenceGardier A. M., Moratalla R., Cuellar B., Sacerdote M., Guibert B., Lebrec H. and Graybiel A. M. ( 2000 ) Interaction between the serotoninergic and dopaminergic systems in d-fenfluramine-induced activation of c-fos and jun B genes in rat striatal neurons. J. Neurochem. 74, 1363 – 1373.en_US
dc.identifier.citedreferenceGerfen C. R., Miyachi S., Paletzki R. and Brown P. ( 2002 ) D1 dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1/2/MAP kinase. J. Neurosci. 22, 5042 – 5054.en_US
dc.identifier.citedreferenceGraybiel A. M., Moratalla R. and Robertson H. A. ( 1990 ) Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. Proc. Natl Acad. Sci. USA 87, 6912 – 6916.en_US
dc.identifier.citedreferenceHarlan R. E. and Garcia M. M. ( 1998 ) Drugs of abuse and immediate-early genes in the forebrain. Mol. Neurobiol. 16, 221 – 267.en_US
dc.identifier.citedreferenceHyman S. E. and Malenka R. C. ( 2001 ) Addiction and the brain: the neurobiology of compulsion and its persistence. Nat. Rev. Neurosci. 2, 695 – 703.en_US
dc.identifier.citedreferenceJaber M., Cador M., Dumartin B., Normand E., Stinus L. and Bloch B. ( 1995 ) Acute and chronic amphetamine treatments differently regulate neuropeptide messenger RNA levels and Fos immunoreactivity in rat striatal neurons. Neuroscience 65, 1041 – 1050.en_US
dc.identifier.citedreferenceJohansson B., Lindstrom K. and Fredholm B. B. ( 1994 ) Differences in the regional and cellular localization of c-fos messenger RNA induced by amphetamine, cocaine and caffeine in the rat. Neuroscience 59, 837 – 849.en_US
dc.identifier.citedreferenceKawaguchi Y., Wilson C. J., Augood S. J. and Emson P. C. ( 1995 ) Striatal interneurones: chemical, physiological and morphological characterization. Trends Neurosci. 18, 527 – 535.en_US
dc.identifier.citedreferenceKeefe K. A. and Gerfen C. R. ( 1995 ) D1–D2 dopamine receptor synergy in striatum: effects of intrastriatal infusions of dopamine agonists and antagonists on immediate early gene expression. Neuroscience 66, 903 – 913.en_US
dc.identifier.citedreferenceKeefe K. A. and Gerfen C. R. ( 1996 ) D1 dopamine receptor-mediated induction of zif268 and c-fos in the dopamine-depleted striatum: differential regulation and independence from NMDA receptors. J. Comp. Neurol. 367, 165 – 176.en_US
dc.identifier.citedreferenceKonradi C., Cole R. L., Heckers S. and Hyman S. E. ( 1994 ) Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J. Neurosci. 14, 5623 – 5634.en_US
dc.identifier.citedreferenceKonradi C., Leveque J. C. and Hyman S. E. ( 1996 ) Amphetamine and dopamine-induced immediate early gene expression in striatal neurons depends on postsynaptic NMDA receptors and calcium. J. Neurosci. 16, 4231 – 4239.en_US
dc.identifier.citedreferenceLaHoste G. J., Henry B. L. and Marshall J. F. ( 2000 ) Dopamine D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials. J. Neurosci. 20, 6666 – 6671.en_US
dc.identifier.citedreferenceLi B. H. and Rowland N. E. ( 1993 ) Dexfenfluramine induces Fos-like immunoreactivity in discrete brain regions in rats. Brain Res. Bull. 31, 43 – 48.en_US
dc.identifier.citedreferenceLindefors N. and Ungerstedt U. ( 1990 ) Bilateral regulation of glutamate tissue and extracellular levels in caudate-putamen by midbrain dopamine neurons. Neurosci. Lett. 115, 248 – 252.en_US
dc.identifier.citedreferenceListe I., Rozas G., Guerra M. J. and Labandeira-Garcia J. L. ( 1995 ) Cortical stimulation induces Fos expression in striatal neurons via NMDA glutamate and dopamine receptors. Brain Res. 700, 1 – 12.en_US
dc.identifier.citedreferenceMcGinty J. F. and Wang J. Q. ( 1998 ) Drugs of abuse and striatal gene expression. Adv. Pharmacol. 42, 1017 – 1019.en_US
dc.identifier.citedreferenceMcPherson R. J. and Marshall J. F. ( 2000 ) Substantia nigra glutamate antagonists produce contralateral turning and basal ganglia Fos expression: interactions with D1 and D2 dopamine receptor agonists. Synapse 36, 194 – 204.en_US
dc.identifier.citedreferenceMoratalla R., Xu M., Tonegawa S. and Graybiel A. M. ( 1996 ) Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor. Proc. Natl Acad. Sci. USA 93, 14928 – 14933.en_US
dc.identifier.citedreferenceNestler E. J., Hope B. T. and Widnell K. L. ( 1993 ) Drug addiction: a model for the molecular basis of neural plasticity. Neuron 11, 995 – 1006.en_US
dc.identifier.citedreferenceParthasarathy H. B. and Graybiel A. M. ( 1997 ) Cortically driven immediate-early gene expression reflects modular influence of sensorimotor cortex on identified striatal neurons in the squirrel monkey. J. Neurosci. 17, 2477 – 2491.en_US
dc.identifier.citedreferencePaxinos G. and Watson C. ( 1998 ) The Rat Brain in Stereotaxic Coordinates, 4th edn. Academic Press, San Diego.en_US
dc.identifier.citedreferenceQuinlan E. M., Philpot B. D., Huganir R. L. and Bear M. F. ( 1999 ) Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo. Nat. Neurosci. 2, 352 – 357.en_US
dc.identifier.citedreferenceRobinson T. E., Browman K. E., Crombag H. S. and Badiani A. ( 1998 ) Modulation of the induction or expression of psychostimulant sensitization by the circumstances surrounding drug administration. Neurosci. Biobehav. Rev. 22, 347 – 354.en_US
dc.identifier.citedreferenceRuskin D. N. and Marshall J. F. ( 1994 ) Amphetamine- and cocaine-induced fos in the rat striatum depends on D2 dopamine receptor activation. Synapse 18, 233 – 240.en_US
dc.identifier.citedreferenceSgambato V., Abo V., Rogard M., Besson M. J. and Deniau J. M. ( 1997 ) Effect of electrical stimulation of the cerebral cortex on the expression of the Fos protein in the basal ganglia. Neuroscience 81, 93 – 112.en_US
dc.identifier.citedreferenceSgambato V., Pages C., Rogard M., Besson M. J. and Caboche J. ( 1998a ) Extracellular signal-regulated kinase (ERK) controls immediate early gene induction on corticostriatal stimulation. J. Neurosci. 18, 8814 – 8825.en_US
dc.identifier.citedreferenceSgambato V., Vanhoutte P., Pages C., Rogard M., Hipskind R., Besson M. J. and Caboche J. ( 1998b ) In vivo expression and regulation of Elk-1, a target of the extracellular-regulated kinase signaling pathway, in the adult rat brain. J. Neurosci. 18, 214 – 226.en_US
dc.identifier.citedreferenceSnyder-Keller A. M. ( 1991 ) Striatal c-fos induction by drugs and stress in neonatally dopamine-depleted rats given nigral transplants: importance of NMDA activation and relevance to sensitization phenomena. Exp. Neurol. 113, 155 – 165.en_US
dc.identifier.citedreferenceStandaert D. G., Friberg I. K., Landwehrmeyer G. B., Young A. B. and Penney J. B. Jr ( 1999 ) Expression of NMDA glutamate receptor subunit mRNAs in neurochemically identified projection and interneurons in the striatum of the rat. Brain Res. Mol. Brain Res. 64, 11 – 23.en_US
dc.identifier.citedreferenceTang Y. P., Shimizu E., Dube G. R., Rampon C., Kerchner G. A., Zhuo M., Liu G. and Tsien J. Z. ( 1999 ) Genetic enhancement of learning and memory in mice. Nature 401, 63 – 69.en_US
dc.identifier.citedreferenceUslaner J., Badiani A., Day H. E., Watson S. J., Akil H. and Robinson T. E. ( 2001a ) Environmental context modulates the ability of cocaine and amphetamine to induce c-fos mRNA expression in the neocortex, caudate nucleus, and nucleus accumbens. Brain Res. 920, 106 – 116.en_US
dc.identifier.citedreferenceUslaner J., Badiani A., Norton C. S., Day H. E., Watson S. J., Akil H. and Robinson T. E. ( 2001b ) Amphetamine and cocaine induce different patterns of c-fos mRNA expression in the striatum and subthalamic nucleus depending on environmental context. Eur. J. Neurosci. 13, 1977 – 1983.en_US
dc.identifier.citedreferenceUslaner J. M., Norton C. S., Watson S. J., Akil H. and Robinson T. E. ( 2003 ) Amphetamine-induced c-fos mRNA expression in the caudate-putamen and subthalamic nucleus: interactions between dose, environment, and neuronal phenotype. J. Neurochem. 85, 105 – 114.en_US
dc.identifier.citedreferenceVargo J. M. and Marshall J. F. ( 1995 ) Time-dependent changes in dopamine agonist-induced striatal Fos immunoreactivity are related to sensory neglect and its recovery after unilateral prefrontal cortex injury. Synapse 20, 305 – 315.en_US
dc.identifier.citedreferenceWang J. Q. and McGinty J. F. ( 1997 ) Intrastriatal injection of a muscarinic receptor agonist and antagonist regulates striatal neuropeptide mRNA expression in normal and amphetamine-treated rats. Brain Res. 748, 62 – 70.en_US
dc.identifier.citedreferenceWang J. Q., Daunais J. B. and McGinty J. F. ( 1994 ) NMDA receptors mediate amphetamine-induced upregulation of zif/268 and preprodynorphin mRNA expression in rat striatum. Synapse 18, 343 – 353.en_US
dc.identifier.citedreferenceWest A. R. and Grace A. A. ( 2002 ) Opposite influences of endogenous dopamine D1 and D2 receptor activation on activity states and electrophysiological properties of striatal neurons: studies combining in vivo intracellular recordings and reverse microdialysis. J. Neurosci. 22, 294 – 304.en_US
dc.identifier.citedreferenceYoung S. T., Porrino L. J. and Iadarola M. J. ( 1991 ) Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors. Proc. Natl Acad. Sci. USA 88, 1291 – 1295.en_US
dc.identifier.citedreferenceYung K. K., Bolam J. P., Smith A. D., Hersch S. M., Ciliax B. J. and Levey A. I. ( 1995 ) Immunocytochemical localization of D1 and D2 dopamine receptors in the basal ganglia of the rat: light and electron microscopy. Neuroscience 65, 709 – 730.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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