Antiepileptic Drug Mechanisms of Action
dc.contributor.author | Macdonald, Robert L. | en_US |
dc.contributor.author | Kelly, Kevin M. | en_US |
dc.date.accessioned | 2010-04-01T15:47:53Z | |
dc.date.available | 2010-04-01T15:47:53Z | |
dc.date.issued | 1993-11 | en_US |
dc.identifier.citation | Macdonald, Robert L.; Kelly, Kevin M. (1993). "Antiepileptic Drug Mechanisms of Action." Epilepsia 34(): S1-S8. <http://hdl.handle.net/2027.42/66291> | en_US |
dc.identifier.issn | 0013-9580 | en_US |
dc.identifier.issn | 1528-1167 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/66291 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7687957&dopt=citation | en_US |
dc.description.abstract | Clinically used antiepileptic drugs (AEDs) decrease membrane excitability by interacting with ion channels or neurotransmitter receptors. Currently available AEDs appear to act on sodium channels, GABA A receptors, or calcium channels. Phenytoin, carbamazepine, and possibly valproate (VPA) decrease high-frequency repetitive firing of action potentials by enhancing sodium channel inactivation. Benzodiazepines and barbiturates enhance GABA A receptor-mediated inhibition. Ethosuximide and possibly VPA reduce a low-threshold calcium current. The mechanisms of action of AEDs currently under development are less clear. Lamotrigine may decrease sustained high-frequency repetitive firing. The mechanisms of action of felbamate are unknown. Gabapentin (GBP) appears to bind to a specific binding site in the central nervous system with a restricted regional distribution, but the identity of the binding site and the mechanism of action of GBP remain uncertain. | en_US |
dc.format.extent | 862077 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1993 International League Against Epilepsy | en_US |
dc.subject.other | Anticonvulsants | en_US |
dc.subject.other | Neuropharmacology | en_US |
dc.subject.other | Neurotransmitters | en_US |
dc.subject.other | GABA | en_US |
dc.subject.other | Phenytoin | en_US |
dc.subject.other | Carbamazepine | en_US |
dc.subject.other | Ethosuximide | en_US |
dc.subject.other | Tri-methadione | en_US |
dc.subject.other | Benzodiazepines | en_US |
dc.subject.other | Barbiturates | en_US |
dc.subject.other | Valproate | en_US |
dc.subject.other | Felbamate | en_US |
dc.subject.other | Gabapentin | en_US |
dc.subject.other | Lamotrigine | en_US |
dc.subject.other | Neural Inhibition | en_US |
dc.subject.other | Sodium | en_US |
dc.subject.other | Calcium | en_US |
dc.title | Antiepileptic Drug Mechanisms of Action | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | *Departments of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | †Physiology, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 7687957 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/66291/1/j.1528-1157.1993.tb05918.x.pdf | |
dc.identifier.doi | 10.1111/j.1528-1157.1993.tb05918.x | en_US |
dc.identifier.source | Epilepsia | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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