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Slow phases of GABA A receptor desensitization: structural determinants and possible relevance for synaptic function
dc.contributor.authorBianchi, Matt T.en_US
dc.contributor.authorMacdonald, Robert L.en_US
dc.date.accessioned2010-04-01T15:50:02Z
dc.date.available2010-04-01T15:50:02Z
dc.date.issued2002-10en_US
dc.identifier.citationBianchi, Matt T.; Macdonald, Robert L. (2002). "Slow phases of GABA A receptor desensitization: structural determinants and possible relevance for synaptic function." The Journal of Physiology 544(1): 3-18. <http://hdl.handle.net/2027.42/66328>en_US
dc.identifier.issn0022-3751en_US
dc.identifier.issn1469-7793en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/66328
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12356876&dopt=citationen_US
dc.format.extent523588 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/octet-stream
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rightsThe Physiological Society 2002en_US
dc.titleSlow phases of GABA A receptor desensitization: structural determinants and possible relevance for synaptic functionen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysiologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum* Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48104-1687en_US
dc.contributor.affiliationother† Departments of †Neurology, Vanderbilt University, Nashville, TN 37212, USAen_US
dc.contributor.affiliationother† †Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37212, USAen_US
dc.contributor.affiliationother§ §Pharmacology, Vanderbilt University, Nashville, TN 37212, USAen_US
dc.identifier.pmid12356876en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/66328/1/jphysiol.2002.020255.pdf
dc.identifier.doi10.1113/jphysiol.2002.020255en_US
dc.identifier.sourceThe Journal of Physiologyen_US
dc.identifier.citedreferenceAkabas, M. H. & Karlin, A. ( 1995 ). Identification of acetylcholine receptor channel-lining residues in the M1 segment of the Α-subunit. Biochemistry 34, 12496 – 12500.en_US
dc.identifier.citedreferenceAkabas, M. H., Kaufmann, C., Archdeacon, P. & Karlin, A. ( 1994 ). Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit. Neuron 13, 919 – 927.en_US
dc.identifier.citedreferenceAkaike, N., Inomata, N. & Tokutomi, N. ( 1987 ). Contribution of chloride shifts to the fade of gamma-aminobutyric acid-gated currents in frog dorsal root ganglion cells. Journal of Physiology 391, 219 – 234.en_US
dc.identifier.citedreferenceAlger, B. E. ( 1991 ). Gating of GABAergic inhibition in hippocampal pyramidal cells. Annals of the New York Academy of Sciences 627, 249 – 263.en_US
dc.identifier.citedreferenceAngelotti, T. P., Uhler, M. D. & Macdonald, R. L. ( 1993 ). Assembly of GABA A receptor subunits: analysis of transient single-cell expression utilizing a fluorescent substrate/marker gene technique. Journal of Neuroscience 13, 1418 – 1428.en_US
dc.identifier.citedreferenceBanke, T. G., Greenwood, J. R., Christensen, J. K., Liljefors, T., Traynelis, S. F., Schousboe, A. & Pickering, D. S. ( 2001 ). Identification of amino acid residues in GluR1 responsible for ligand binding and desensitization. Journal of Neuroscience 21, 3052 – 3062.en_US
dc.identifier.citedreferenceBartos, M., Vida, I., Frotscher, M., Geiger, J. R. & Jonas, P. ( 2001 ). Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network. Journal of Neuroscience 21, 2687 – 2698.en_US
dc.identifier.citedreferenceBianchi, M. T., Haas, K. F. & Macdonald, R. L. ( 2001 ). Structural determinants of fast desensitization and desensitization-deactivation coupling in GABA A receptors. Journal of Neuroscience 21, 1127 – 1136.en_US
dc.identifier.citedreferenceBianchi, M. T. & Macdonald, R. L. ( 2001 a ). Agonist trapping by GABA A receptor channels. Journal of Neuroscience 21, 9083 – 9091.en_US
dc.identifier.citedreferenceBianchi, M. T. & Macdonald, R. L. ( 2001 b ). Mutation of the 9′ leucine in the GABA A receptor Γ2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states. Neuropharmacology 41, 737 – 744.en_US
dc.identifier.citedreferenceBrickley, S. G., Cull-Candy, S. G. & Farrant, M. ( 1999 ). Single-channel properties of synaptic and extrasynaptic GABA A receptors suggest differential targeting of receptor subtypes. Journal of Neuroscience 19, 2960 – 2973.en_US
dc.identifier.citedreferenceCelentano, J. J. & Wong, R. K. S. ( 1994 ). Multiphasic desensitization of the GABA A receptor in outside-out patches. Biophysical Journal 66, 1039 – 1050.en_US
dc.identifier.citedreferenceChen, L., Wang, H., Vicini, S. & Olsen, R. W. ( 2000 ). The gamma-aminobutyric acid type A (GABA A ) receptor-associated protein (GABARAP). promotes GABA A receptor clustering and modulates the channel kinetics. Proceedings of the National Academy of Sciences of the USA 97, 11557 – 11562.en_US
dc.identifier.citedreferenceDalziel, J. E., Cox, G. B., Gage, P. W. & Birnir, B. ( 2000 ). Mutating the highly conserved second membrane-spanning region 9′ leucine residue in the Α1 or Β1 subunit produces subunit-specific changes in the function of human Α1Β1 Γ-aminobutyric acid A receptors. Molecular Pharmacology 57, 875 – 882.en_US
dc.identifier.citedreferenceDavies, C. H. & Collingridge, G. L. ( 1993 ). The physiological regulation of synaptic inhibition by GABA B autoreceptors in rat hippocampus. Journal of Physiology 472, 245 – 265.en_US
dc.identifier.citedreferenceDavies, C. H., Davies, S. N. & Collingridge, G. L. ( 1990 ). Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus. Journal of Physiology 424, 513 – 531.en_US
dc.identifier.citedreferenceDomingueZ-Perrot, C., FeltZ, P. & Poulter, M. O. ( 1997 ). Recombinant GABA A receptor desensitization: the role of the Γ2 subunit and its physiological significance. Journal of Physiology 497, 145 – 159.en_US
dc.identifier.citedreferenceFisher, J. L. & Macdonald, R. L. ( 1997 ). Single channel properties of GABA A receptors containing Γ2 or Δ subtypes expressed with Α1 and Β3 subtypes in L929 cells. Journal of Physiology 505, 283 – 297.en_US
dc.identifier.citedreferenceGalarreta, M. & Hestrin, S. ( 1998 ). Frequency-dependent synaptic depression and the balance of excitation and inhibition in the neocortex. Nature Neuroscience 1, 587 – 594.en_US
dc.identifier.citedreferenceGreenfield, L. J. Jr & Macdonald, R. L. ( 1996 ). Whole-cell and single-channel alpha1 beta1 gamma2S GABA A receptor currents elicited by a ‘multipuffer’ drug application device. PflÜgers Archiv 432, 1080 – 1090.en_US
dc.identifier.citedreferenceGreenfield, L. J. Jr, Sun, F., Neelands, T. R., Burgard, E. C., Donnelly, J. L. & Macdonald, R. L. ( 1997 ). Expression of functional GABA A receptors in transfected L929 cells isolated by immunomagnetic bead separation. Neuropharmacology 36, 63 – 73.en_US
dc.identifier.citedreferenceHaas, K. F. & Macdonald, R. L. ( 1999 ). GABA A receptor subunit Γ2 and Δ subtypes confer unique kinetic properties on recombinant GABA A receptor currents in mouse fibroblasts. Journal of Physiology 514, 27 – 45.en_US
dc.identifier.citedreferenceIm, W. B., Binder, J. A., Dillon, G. H., Pregenzer, J. F., Im, H. K. & Altman, R. A. ( 1995 ). Acceleration of GABA-dependent desensitization by mutating threonine 266 to alanine of the alpha 6 subunit of rat GABA A receptors. Neuroscience Letters 186, 203 – 207.en_US
dc.identifier.citedreferenceIsaacson, J. S., Solis, J. M. & Nicoll, R. A. ( 1993 ). Local and diffuse synaptic actions of GABA in the hippocampus. Neuron 10, 165 – 175.en_US
dc.identifier.citedreferenceJiang, L., Sun, S., Nedergaard, M. & Kang, J. ( 2000 ), Paired-pulse modulation at individual GABAergic synapses in rat hippocampus). Journal of Physiology 523. 425 – 439.en_US
dc.identifier.citedreferenceJones, M. V. & Westbrook, G. L. ( 1995 ). Desensitized states prolong GABA A channel responses to brief agonist pulses. Neuron 15, 181 – 191.en_US
dc.identifier.citedreferenceJones, M. V. & Westbrook, G. L. ( 1996 ). The impact of receptor desensitization on fast synaptic transmission. Trends in Neurosciences 19, 96 – 101.en_US
dc.identifier.citedreferenceJones, M. V. & Westbrook, G. L. ( 1997 ). Shaping of IPSCs by endogenous calcineurin activity. Journal of Neuroscience 17, 7626 – 7633.en_US
dc.identifier.citedreferenceLabarca, C., Nowak, M. W., Zhang, H., Tang, L., Deshpande, P. & Lester H. A. ( 1995 ). Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature 376, 514 – 516.en_US
dc.identifier.citedreferenceLerma, J., HerranZ, A. S., Herreras, O., Abraira, V. & Martin, D. R. ( 1986 ). In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis. Brain Research 384, 145 – 155.en_US
dc.identifier.citedreferenceLynch, J. W., Rajendra, S., Pierce, K. D., Handford, C. A., Barry, P. H. & Schofield, P. R. ( 1997 ). Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel. EMBO Journal 16, 110 – 120.en_US
dc.identifier.citedreferenceMcCarren, M. & Alger, B. E. ( 1985 ). Use-dependent depression of IPSPs in rat hippocampal pyramidal cells in vitro. Journal of Neurophysiology 53, 557 – 571.en_US
dc.identifier.citedreferenceMcKernan, R. M. & Whiting, P. J. ( 1996 ). Which GABA A -receptor subtypes really occur in the brain? Trends in Neurosciences 19, 139 – 143.en_US
dc.identifier.citedreferenceNaranjo, D. & Brehm, P. ( 1993 ). Modal shifts in acetylcholine receptor channel gating confer subunit-dependent desensitization. Science 260, 1811 – 1814.en_US
dc.identifier.citedreferenceNusser, Z., Sieghart, W. & Somogyi, P. ( 1998 ). Segregation of different GABA A receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. Journal of Neuroscience 18, 1693 – 1703.en_US
dc.identifier.citedreferenceOlsen, R. W. & Macdonald, R. L. ( 2002 ). GABA A receptor complex: structure and function. In Glutamate and GABA Receptors and Transporters: Structure, Function, and Pharmacology, ed. Egebjerg, J., Schousboe, A. & Krogsgaard-Larsen, P., chap. 9, pp. 203 – 235. Taylor and Francis, New York.en_US
dc.identifier.citedreferenceOverstreet, L. S., Jones, M. V. & Westbrook, G. L. ( 2000 ). Slow desensitization regulates the availability of synaptic GABA(A) receptors. Journal of Neuroscience 20, 7914 – 7921.en_US
dc.identifier.citedreferenceRevah, F., Bertand, D., Galzi, J. L., Devillers-Thiery, A., Mulle, C., Hussy, N., Bertrand, S., Ballivet, M. & Changeux, J. P. ( 1991 ). Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor. Nature 353, 846 – 849.en_US
dc.identifier.citedreferenceRossi, D. J. & Hamann, M. ( 1998 ). Spillover-mediated transmission at inhibitory synapses promoted by high affinity alpha6 subunit GABA(A) receptors and glomerular geometry. Neuron 20, 783 – 795.en_US
dc.identifier.citedreferenceSaxena, N. C. & Macdonald, R. L. ( 1994 ). Assembly of GABA A receptor subunit: role of the Δ subunit. Journal of Neuroscience 14, 7077 – 7086.en_US
dc.identifier.citedreferenceStern-Bach, Y., Russo, S., Neuman, M. & Rosenmund, C. ( 1998 ). A point mutation in the glutamate binding site blocks desensitization of AMPA receptors. Neuron 21, 907 – 918.en_US
dc.identifier.citedreferenceStevens, C. F. & Wang, Y. ( 1995 ). Facilitation and depression at single central synapses. Neuron 14, 795 – 802.en_US
dc.identifier.citedreferenceThompson, S. M. & Gahwiler, B. H. ( 1989 ). Activity-dependent disinhibition. I. Repetitive stimulation reduces IPSP driving force and conductance in the hippocampus in vitro. Journal of Neurophysiology 61, 501 – 511.en_US
dc.identifier.citedreferenceTia, S., Wang, J. F., Kotchabhakdi, N. & Vicini, S. ( 1996 ). Distinct deactivation and desensitization kinetics of recombinant GABA A receptors. Neuropharmacology 35, 1375 – 1382.en_US
dc.identifier.citedreferenceUnwin, N. ( 1995 ). Acetylcholine receptor channel imaged in the open state. Nature 373, 37 – 43.en_US
dc.identifier.citedreferenceWilson, G. G. & Karlin, A. ( 1998 ). The location of the gate in the acetylcholine receptor channel. Neuron 20, 1269 – 1281.en_US
dc.identifier.citedreferenceXu, M. & Akabas, M. H. ( 1996 ). Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA A receptor Α1 subunit. Journal of General Physiology 107, 195 – 205.en_US
dc.identifier.citedreferenceYakel, J. L., Lagrutta, A., Adelman, J. P. & North, R. A. ( 1993 ). Single amino acid substitution affects desensitization kinetics of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes. Proceedings of the National Academy of Sciences of the USA 90, 5030 – 5033.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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