Inhibition of Nitric Oxide Synthase Activity Attenuates Striatal Malonate Lesions in Rats
dc.contributor.author | Silverstein, Faye Sarah | en_US |
dc.date.accessioned | 2010-04-01T15:56:12Z | |
dc.date.available | 2010-04-01T15:56:12Z | |
dc.date.issued | 1995-05 | en_US |
dc.identifier.citation | Silverstein, Faye S. (1995). "Inhibition of Nitric Oxide Synthase Activity Attenuates Striatal Malonate Lesions in Rats." Journal of Neurochemistry 64(5): 2362-2365. <http://hdl.handle.net/2027.42/66435> | en_US |
dc.identifier.issn | 0022-3042 | en_US |
dc.identifier.issn | 1471-4159 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/66435 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7536812&dopt=citation | en_US |
dc.description.abstract | Mitochondrial inhibitors such as malonate are potent neurotoxins in vivo. Intrastriatal injections of malonate result in neuronal damage reminiscent of “excitotoxic” lesions produced by compounds that activate NMDA receptors. Although the mechanism of cell death produced by malonate is uncertain, overactivation of NMDA receptors may be involved; pretreatment of animals with NMDA antagonists provides neuroprotection against malonate lesions. NMDA receptor activation stimulates the enzyme nitric oxide (NO) synthase (NOS). Elevated tissue levels of NO may generate highly reactive intermediates that impair mitochondrial function. We hypothesized that NO may be a mediator of malonate toxicity. We investigated whether in vivo inhibition of NO production by the NOS inhibitor N Ω -nitro-l-arginine (NLA) would attenuate lesions produced by intrastriatal injections of malonate. We found that systemic injections of 3 mg/kg of NLA significantly reduced the extent of histologic damage elicited by intrastriatal injections of 1.5 µmol of malonate in adult rats. | en_US |
dc.format.extent | 635340 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Science Ltd | en_US |
dc.rights | Blackwell Science Inc | en_US |
dc.subject.other | Malonate Lesions | en_US |
dc.subject.other | Rat Striatum | en_US |
dc.subject.other | Nitric Oxide | en_US |
dc.subject.other | Nitric Oxide Synthase Inhibition | en_US |
dc.subject.other | N Ω -Nitro-l-Arginine | en_US |
dc.title | Inhibition of Nitric Oxide Synthase Activity Attenuates Striatal Malonate Lesions in Rats | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | † Pediatrics, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 7536812 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/66435/1/j.1471-4159.1995.64052362.x.pdf | |
dc.identifier.doi | 10.1046/j.1471-4159.1995.64052362.x | en_US |
dc.identifier.source | Journal of Neurochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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