Expression of Adhesion Molecules during Tooth Resorption in Feline Teeth: A Model System for Aggressive Osteoclastic Activity
dc.contributor.author | Shigeyama, Y. | en_US |
dc.contributor.author | Grove, T. K. | en_US |
dc.contributor.author | Strayhorn, C. L. | en_US |
dc.contributor.author | Somerman, Martha J. | en_US |
dc.date.accessioned | 2010-04-13T18:43:39Z | |
dc.date.available | 2010-04-13T18:43:39Z | |
dc.date.issued | 1996 | en_US |
dc.identifier.citation | Shigeyama, Y.; Grove, T.K.; Strayhorn, C.; Somerman, M.J. (1996). "Expression of Adhesion Molecules during Tooth Resorption in Feline Teeth: A Model System for Aggressive Osteoclastic Activity." Journal of Dental Research 9(75): 1650-1657. <http://hdl.handle.net/2027.42/66661> | en_US |
dc.identifier.issn | 0022-0345 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/66661 | |
dc.description.abstract | Tooth resorption, a common feline dental problem, is often initiated at the cemento-enamel junction and hence is called cat 'neck' lesion. Studies have demonstrated that osteoclasts/odontoclasts are increased and activated at resorption sites, and that areas of resorption are partly repaired by formation of tissues resembling bone, cementum, and possibly dentin. However, the cellular/molecular mechanisms/factors involved in resorption and repair are unknown. In this study of tissues from cats with 'neck' lesions, we used specific antibodies and immunohistochemical analyses to examine adhesion molecules associated with mineralized tissues, bone sialoprotein (BSP) and osteopontin (OPN), and a cell-surface receptor linked with these molecules, α vβ3, for their localization in these lesions. In addition, to determine general cellular activity during repair, we performed in situ hybridization using a type I collagen riboprobe. Results showed OPN localized to resorption fronts and reversal lines, while BSP was localized to reversal lines. However, some osteoclasts and odontoblasts "sat" on mineralized surfaces not associated with OPN. The cell-surface receptor, αvβ 3, was localized to surfaces of osteoclasts/odontoclasts. Type I collagen mRNA was expressed where osteoblasts attempted to repair mineralized tissue. In contrast, odontoblasts did not express mRNA for type I collagen. This study suggests that osteoclastic resorption is the predominant activity in 'neck' lesions and that this activity was accompanied, at least in part, by increased concentrations of OPN and an associated integrin, α vβ3, at resorption sites. Lack of collagen expression by odontoblasts indicates that odontoblasts do not play an active role in attempts at repair. | en_US |
dc.format.extent | 3108 bytes | |
dc.format.extent | 1642405 bytes | |
dc.format.mimetype | text/plain | |
dc.format.mimetype | application/pdf | |
dc.publisher | SAGE Publications | en_US |
dc.subject.other | αvβ3 | en_US |
dc.subject.other | bone sialoprotein | en_US |
dc.subject.other | odontoclasts | en_US |
dc.subject.other | osteoclasts | en_US |
dc.subject.other | osteopontin. | en_US |
dc.title | Expression of Adhesion Molecules during Tooth Resorption in Feline Teeth: A Model System for Aggressive Osteoclastic Activity | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Periodontics/Prevention/Geriatrics, Department of Pharmacology, School of Medicine, University of Michigan, 1011 N. University, Ann Arbor, Michigan 48109-1078 | en_US |
dc.contributor.affiliationother | Department of Periodontics/Prevention/Geriatrics | en_US |
dc.contributor.affiliationother | The Florida Veterinary Dental Clinic, 875 17th Street, Vero Beach, Florida 32960 | en_US |
dc.contributor.affiliationother | Department of Periodontics/Prevention/Geriatrics | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/66661/2/10.1177_00220345960750090601.pdf | |
dc.identifier.doi | 10.1177/00220345960750090601 | en_US |
dc.identifier.citedreference | Albelda SM, Buck CA (1990). Integrins and other cell adhesion molecules. FASEB J 4:2868-2880. | en_US |
dc.identifier.citedreference | Bianco P., Fisher LW, Young MF, Termine JD, Robey PG (1991). Expression of bone sialoprotein (BSP) in developing human tissues. Calcif Tissue Int 49:421-426. | en_US |
dc.identifier.citedreference | Boskey AL, Maresca M., Ullrich W., Doty SB, Butler WT, Prince CW (1993). Osteopontin-hydroxyapatite interactions in vitro: inhibition of hydroxyapatite formation and growth in a gelatin-gel. Bone Miner 22:147-159. | en_US |
dc.identifier.citedreference | Chen J., Mc Culloch C., Sodek J. (1993). Bone sialoprotein in developing porcine dental tissues: cellular expression and comparison of tissue localization with osteopontin and osteonectin. Arch Oral Biol 38:241-249. | en_US |
dc.identifier.citedreference | Coles S. (1990). The prevalence of buccal cervical root resorptions in Australian cats. J Vet Dent 7:14-16. | en_US |
dc.identifier.citedreference | Denhardt DT, Chambers AF (1994). Overcoming obstacles to metastasis-defenses against host defenses: Osteopontin (OPN) as a shield against attack by cytotoxic host cells. J Cell Biochem 56:48-51. | en_US |
dc.identifier.citedreference | Denhardt DT, Guo X. (1993). Osteopontin: a protein with diverse functions. FASEB J 7:1475-1482. | en_US |
dc.identifier.citedreference | Fisher LW (1992). Structure/function studies of the sialoglycoproteins and proteoglycans of bone: It is still the early days. In: Chemistry and biology of mineralized tissues. Slavkin H, Price P, editors. Amsterdam-New York: Excerpta Medica, pp. 177-187. | en_US |
dc.identifier.citedreference | Harvey CE (1992). Epidemiology of periodontal conditions in dog and cats. Proceedings of the Sixth Annual Veterinary Dental Forum, the American Veterinary Dental College and the Academy of Veterinary Dentistry, Nov 13-15, 1992, Las Vegas, Nevada. Nabisco Foods Company, pp. 45-46. | en_US |
dc.identifier.citedreference | Helfrich MH, Nesbitt SA, Dorey EL, Horton MA (1992). Rat osteoclasts adhere to a wide range of RGD (Arg-Gly-Asp) peptide-containing proteins, including the bone sialoproteins and fibronectin, via a β3 integrin. J Bone Miner Res 7:335-343. | en_US |
dc.identifier.citedreference | Hunter GK, Goldberg HA (1994). Modulation of crystal formation by bone phosphoproteins: role of glutamic acid-rich sequences in the nucleation of hydroxyapatite by bone sialoprotein. Biochem 302:175-179. | en_US |
dc.identifier.citedreference | Hunter GK, Kyle CL, Goldberg HA (1994). Modulation of crystal formation by bone phosphoproteins: structural specificity of the osteopontin-mediated inhibition of hydroxyapatite formation. Biochem J 300:723-728. | en_US |
dc.identifier.citedreference | Kingsley DM (1994). The TGF β superfamily: new members, new receptors, and new genetic tests of function in different organisms. Gene Dev 8:133-146. | en_US |
dc.identifier.citedreference | Lakkakorpi PT, Horton MA, Helfrich MH, Karhukorpi E-K., Vaananen HK (1991). Vitronectin receptor has a role in bone resorption but does not mediate tight sealing zone attachment of osteoclasts to the bone surface. J Cell Biol 115:1179-1186. | en_US |
dc.identifier.citedreference | Mac Neil RL, Sheng N., Strayhorn C., Fisher LW, Somerman MJ (1994). Bone sialoprotein is localized to the root surface during cementogenesis. J Bone Miner Res 9:1597-1606. | en_US |
dc.identifier.citedreference | Maeda H., Kukita T., Akamine A., Kukita A., Iijima T. (1994). Localization of osteopontin in resorption lacunae formed by osteoclast-like cells: a study by a novel monoclonal antibody which recognizes rat osteopontin. Histochem 102:247-254. | en_US |
dc.identifier.citedreference | Masi L., Brandi ML, Robey PG, Crescioli C., Calvo JC, Bernabei P., et al. (1995). Biosynthesis of bone sialoprotein by a human osteoclast-like cell line (FLG 29.1). J Bone Miner Res 10:187-196. | en_US |
dc.identifier.citedreference | Mc Kee MD, Nanci A. (1996). Osteopontin at mineralized tissue interfaces in bone, teeth and osseointegrated implants: Ultrastructural distribution and implications for mineralized tissue formation, turnover and repair. Microsc Res Technique 33:141-164. | en_US |
dc.identifier.citedreference | Oguro I., Ozawa H. (1988). The histochemical localization of acid phosphatase activity in BMU. J Bone Min Metab 6:44-49. | en_US |
dc.identifier.citedreference | Okuda A., Harvey CE (1992a). Etiopathogenesis of feline dental resorptive lesions. Vet Clin North Am Small Anim Pract 22:1385-1404. | en_US |
dc.identifier.citedreference | Okuda A., Harvey CE (1992b). Immunohistochemical distributions of interleukins as possible stimulators of odontoclastic resorption activity in feline dental resorptive lesions. Proceedings of the Sixth Annual Veterinary Dental Forum, the American Veterinary Dental College and the Academy of Veterinary Dentistry, Nov 13-15, 1992, Las Vegas, Nevada. Nabisco Foods Company, pp. 41-43. | en_US |
dc.identifier.citedreference | Patarca R., Saavedra RA, Cantor H. (1993). Molecular and cellular basis of genetic resistance to bacterial infection: The role of the early T-lymphocyte activation-1/osteopontin gene. Crit Rev Immunol 13:225-246. | en_US |
dc.identifier.citedreference | Regezi JA, Sciubba JJ (1989). Abnormalities of dental pulp: Internal resorption. In: Oral pathology: Clinical-pathologic correlations. Philadelphia: W.B. Saunders Co., pp. 483-484. | en_US |
dc.identifier.citedreference | Reichart PA, Durr U.-M, Triadan H., Vickendey G. (1984). Periodontal disease in the domestic cat. A histopathologic study. J Periodont Res 19:67-75. | en_US |
dc.identifier.citedreference | Reinholt FP, Hultenby K., Oldberg A., Heinegard D. (1990). Osteopontin-a possible anchor of osteoclasts to bone. Proc Natl Acad Sci USA 87:4473-4475. | en_US |
dc.identifier.citedreference | Ross FP, Chappel J., Alvarez JI, Sander D., Butler WT, Farach-Carson MC, et al. (1993). Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin αvβ3 potentiate bone resorption. J Biol Chem 268:9901-9907. | en_US |
dc.identifier.citedreference | Schneck GW, Osborn JW (1976). Neck lesions in the teeth of cats. Vet Rec 99:100. | en_US |
dc.identifier.citedreference | Senger DG, Perruzzi CA, Papadopoulos A., Tenen DG (1989). Purification of a human milk protein closely similar to tumor-secreted phosphoproteins and osteopontin. Biochem Biophys Acta 996:43-48. | en_US |
dc.identifier.citedreference | Shiraga H., Min W., Van Dusen WJ, Clayman MD, Miner D., Terrell CH, et al. (1992). Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily. Proc Natl Acad Sci USA 89:426-430. | en_US |
dc.identifier.citedreference | Sodek J., Chen J., Kasugai S., Nagata T., Zhang Q., Mc Kee MD, et al. (1992). Elucidating the functions of bone sialoprotein and osteopontin in bone formation. In: Chemistry and biology of mineralized tissues. Slavkin H, Price P, editors. Amsterdam- New York: Excerpta Medica, pp. 297-307. | en_US |
dc.identifier.citedreference | Suzuki S., Argraves WS, Pytela R., Arai H., Krusius T., Pierschbacher MD, et al. (1986). c DNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors. Proc Natl Acad Sci USA 83:8614-8618. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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