Expression of Keratinocyte Growth Factor in Periapical Lesions
dc.contributor.author | Gao, Z. | en_US |
dc.contributor.author | Flaitz, C. M. | en_US |
dc.contributor.author | Mackenzie, I. C. | en_US |
dc.date.accessioned | 2010-04-13T18:44:56Z | |
dc.date.available | 2010-04-13T18:44:56Z | |
dc.date.issued | 1996 | en_US |
dc.identifier.citation | Gao, Z.; Flaitz, C.M.; Mackenzie, I.C. (1996). "Expression of Keratinocyte Growth Factor in Periapical Lesions." Journal of Dental Research 9(75): 1658-1663. <http://hdl.handle.net/2027.42/66683> | en_US |
dc.identifier.issn | 0022-0345 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/66683 | |
dc.description.abstract | The epithelial proliferation associated with inflammatory periapical lesions and with periapical cyst formation represents an interesting but poorly understood pathological change. Keratinocyte growth factor (KGF) is a recently identified growth factor that is produced by stromal fibroblasts and acts specifically to stimulate epithelial growth and differentiation. To investigate its possible role in the activation of the normally quiescent rests of Malassez, we examined the expression of KGF by in situ hybridization of sections of normal periodontal ligament (PDL) and of 12 periapical granulomas or cysts. Normal PDL and periapical granulomas with scant inflammatory infiltration showed few cells expressing message for KGF. However, KGFexpressing cells were found in the connective tissue stroma close to dense foci of inflammatory cells and to proliferating epithelial elements and cystic epithelial linings. Examination of tissues by the reverse-transcription polymerase chain reaction (RT-PCR) showed KGF expression in 4 specimens of periapical lesions but low or undetectable levels in normal PDL. These observations suggest that the induction of KGF expression in the stromal cells of periapical lesions may play an important role in stimulating the epithelial proliferation associated with cyst formation. | en_US |
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dc.format.extent | 973819 bytes | |
dc.format.mimetype | text/plain | |
dc.format.mimetype | application/pdf | |
dc.publisher | SAGE Publications | en_US |
dc.subject.other | Keratinocyte Growth Factor | en_US |
dc.subject.other | Periapical Lesions | en_US |
dc.subject.other | Inflammatory Cysts | en_US |
dc.subject.other | RT/PCR | en_US |
dc.subject.other | In Situ Hybridization. | en_US |
dc.title | Expression of Keratinocyte Growth Factor in Periapical Lesions | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Cariology, School of Dentistry, University of Michigan, 1011 N. University, Ann Arbor, Michigan 48109-1078 | en_US |
dc.contributor.affiliationother | Dental Branch, University of Texas, Houston Health Science Center | en_US |
dc.contributor.affiliationother | Dental Branch, University of Texas, Houston Health Science Center | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/66683/2/10.1177_00220345960750090701.pdf | |
dc.identifier.doi | 10.1177/00220345960750090701 | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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