The Expression of the Epithelial Blood-group Substances: Normal and Malignant Tissues
dc.contributor.author | George, D. I. | en_US |
dc.contributor.author | Hanks, Carl T. | en_US |
dc.contributor.author | Lopatin, Dennis E. | en_US |
dc.date.accessioned | 2010-04-13T18:47:00Z | |
dc.date.available | 2010-04-13T18:47:00Z | |
dc.date.issued | 1980 | en_US |
dc.identifier.citation | George, D.I.; Hanks, C.T.; Lopatin, D.E. (1980). "The Expression of the Epithelial Blood-group Substances: Normal and Malignant Tissues." Journal of Dental Research 11(59): 2014-2020. <http://hdl.handle.net/2027.42/66719> | en_US |
dc.identifier.issn | 0022-0345 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/66719 | |
dc.description.abstract | The blood-group isoantigens are macromolecules localized to the plasma membranes of certain epithelial tissues.2,11-15 These substances are not detectable on the epithelium once it has undergone malignant transformation.2,9,13 Results of this investigation have demonstrated that the loss of detectability of the blood-group isoantigens does not appear to be related to a "masking" effect by an increase in surface sialic acid. Using fluorescein-labeled lectins specific for sugar subunits which are components of the blood-group oligosaccharide chain, it was found that the malignant cells and cells of the para basal layer of normal oral epithelium had high levels of N-acetyl-D-glucosamine (GlcNAC), the subterminal sugar residue of the blood-group chain. The basal cells of normal epithelium and a minority of the malignant cells demonstrated levels of D-galactose-N-acetyl-D-galactosamine, which are the most proximal blood-group sugar subunits, as well as subunits of other membrane antigens. Our results indicate that malignant cells seem to be capable of synthesizing the blood-group oligosaccharide chains to the same level as the normal cells of the para basal layer of stratified squamous epithelium. This level is just subjacent to the terminal D-galactose residue of the blood-group precursor chain. Increased or decreased differentiation characteristics of squamous cell carcinomas did not alter the level of blood-group synthesis. However, there may be a correlation between the level of synthesis of these antigens and the ability of the cells to demonstrate motility and to proliferate. | en_US |
dc.format.extent | 3108 bytes | |
dc.format.extent | 852390 bytes | |
dc.format.mimetype | text/plain | |
dc.format.mimetype | application/pdf | |
dc.publisher | SAGE Publications | en_US |
dc.title | The Expression of the Epithelial Blood-group Substances: Normal and Malignant Tissues | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Oral Pathology and Immunology, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Departments of Oral Pathology and Immunology, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Departments of Oral Pathology and Immunology, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/66719/2/10.1177_00220345800590112001.pdf | |
dc.identifier.doi | 10.1177/00220345800590112001 | en_US |
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dc.identifier.citedreference | George, D.I. ; Hanks, C.T.; Courtney, R.M.; Lopatin, D.E.: The Relationship Between the Expression of the Epithelial Blood-group Substances and Malignancy; A Preliminary Report, J Dent Res 59:831, 1980. | en_US |
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dc.identifier.citedreference | Dabelsteen, E. and Road-Peterson, B.: Loss of Epithelial Blood-group Antigens A and B in Oral Premalignant Lesions, Acta Path Microbiol Scand, Sect A, 83:292 1975. | en_US |
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dc.identifier.citedreference | Mackenzie, I.C. ; Dabelsteen, E.; and Zimmerman, K.: The Relationship Between Expression of Epithelial B Blood-group Antigen, Cell Movement, and Proliferation, Acta Path Microbiol Scand, Sect A 85:49, 1977. | en_US |
dc.identifier.citedreference | Podosky, D.K. ; Weiser, M.M.; and Isselbacher, R.J.: A Cancer-associated Galactosyltransferase Isoenzyme, N Engl J Med 29(B):703, 1978. | en_US |
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dc.identifier.citedreference | Liu, P.I. : Carcinoma of the Oral Cavity Evaluated by the Specific Red Cell Adherence Test, Oral Surg 38:56, 1974. | en_US |
dc.identifier.citedreference | Dabelsteen, E. and Pindborg, J.J.: Loss of Epithelial Blood-group Substance A in Oral Carcinomas, Acta Path Microbiol Scand, Sect A 81:435, 1973. | en_US |
dc.identifier.citedreference | Watkins: The Blood-group Substances, Science 152, 1966. | en_US |
dc.identifier.citedreference | Peters, B., Personal communication. | en_US |
dc.identifier.citedreference | Manual of Histologic Staining (AFIP), L. G. Luna, Ed., Mc Graw-Hill Co., 1968. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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