A New Biological Approach To Vital Pulp Therapy
dc.contributor.author | Rutherford, Bruce | en_US |
dc.contributor.author | Fitzgerald, Mark | en_US |
dc.date.accessioned | 2010-04-13T19:01:20Z | |
dc.date.available | 2010-04-13T19:01:20Z | |
dc.date.issued | 1995 | en_US |
dc.identifier.citation | Rutherford, Bruce; Fitzgerald, Mark (1995). "A New Biological Approach To Vital Pulp Therapy." Critical Reviews in Oral Biology & Medicine 3(6): 218-229. <http://hdl.handle.net/2027.42/66969> | en_US |
dc.identifier.issn | 1045-4411 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/66969 | |
dc.description.abstract | Molecular biology is providing opportunities to develop new strategies or agents for the treatment of a wide variety of diseases. The availability of large amounts of highly purified proteins produced by recombinant DNA techniques is an obvious example. Recent evidence has implicated proteins belonging to the bone morphogenetic protein (BMP) subgroup of the transforming growth factor beta supergene family in tooth formation and dentinogenesis. It has long been known that bone and dentin contain bone morphogenetic protein activity. Recently, recombinant human BMP-2, -4, and -7 (also known as OP-1 ) have been shown to induce reparative dentin formation in experimental models of large direct pulp exposures in permanent teeth. The manner in which these agents act appears unique. New reparative dentin replaces the stimulating agents applied directly to the partially amputated pulp. Hence, the new tissue forms contiguous with, largely superficial to, and not at the expense of the remaining vital pulp tissue. This suggests a therapeutic approach permitting the induction of a predetermined and controlled amount of reparative dentin. Additionally, OP-l has been associated with the formation of reparative dentin after application to a freshly cut but intact layer of dentin. These findings may provide future clinicians with additional options for the treatment of substantially damaged or diseased vital teeth. | en_US |
dc.format.extent | 3108 bytes | |
dc.format.extent | 1257113 bytes | |
dc.format.mimetype | text/plain | |
dc.format.mimetype | application/pdf | |
dc.publisher | SAGE Publications | en_US |
dc.subject.other | Bone Morphogenetic Proteins | en_US |
dc.subject.other | Reparative Dentin | en_US |
dc.subject.other | Reactionary Dentin | en_US |
dc.subject.other | Odontoblast Differentiation. | en_US |
dc.title | A New Biological Approach To Vital Pulp Therapy | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan School of Dentistry, 1011 N.University, Ann Arbor, Ml 48109-1078 | en_US |
dc.contributor.affiliationum | University of Michigan School of Dentistry, 1011 N.University, Ann Arbor, Ml 48109-1078 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/66969/2/10.1177_10454411950060030401.pdf | |
dc.identifier.doi | 10.1177/10454411950060030401 | en_US |
dc.identifier.citedreference | Anneroth G., Bang G. (1972). The effect of allogeneic demineralized dentin as a pulp capping agent in Java monkeys. Odontol Revy 23:315-328. | en_US |
dc.identifier.citedreference | Bang G. (1972). Induction of heterotopic bone formation by demineralized dentin in guinea pigs: antigenicity of the dentin matrix. I Oral Pathol 1:172-185. | en_US |
dc.identifier.citedreference | Bang G. (1973). Induction of heterotopic bone formation by demineralized dentin in rats and guinea pigs. Scand J Dent Res 81:230-239. | en_US |
dc.identifier.citedreference | Bang G., Johannessen JV (1972). The effect of proteolytic enzymes on the induction of heterotypic bone formation by demineralized dentin in guinea pigs. I Oral Pathol 1:221-230. | en_US |
dc.identifier.citedreference | Bang G., Urist MR (1967a). Bone induction in excavation chambers in matrix of decalcified dentin. Arch Surg 94:781-789. | en_US |
dc.identifier.citedreference | Bang G., Urist MR (1967b). Recalcification of decalcified dentin in the living animal. I Dent Res 46:722-730. | en_US |
dc.identifier.citedreference | Bang G., Nordenram A., Anneroth G. (1972). Allogenic demineralized dentin implants in jaw defects of Java monkeys. Int J Oral Surg 1:126-136. | en_US |
dc.identifier.citedreference | Baume LL (1980). The biology of pulp and dentine: a historic, terminologic, taxonomic, histological-biochemical, embryonic and clinical survey. In: The biology of pulp and dentine. Meyers HM, editor. Basel: Karger, pp. 159-182. | en_US |
dc.identifier.citedreference | Begue-Kirn C., Smith AJ, Ruch JV, Wozney JM, Purchio A., Hartmann D., et al. (1992). Effects of dentin proteins, transforming growth factor β1 (TGF-β1) and bone morphogenetic protein-2 on the differentiation of odontoblasts in vitro. Int J Dev Biol 36:491-503. | en_US |
dc.identifier.citedreference | Begue-Kirn C., Smith A.), Loriot M., Kupferle C., Ruch JV, Lesot H. (1994). Comparative analysis of TGF-βs, BMPs, IGF-1, msxs fibronectin, osteonectin, and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation. Int J Dev Biol 38:405-420. | en_US |
dc.identifier.citedreference | Bessho K., Tanaka N., Matsumoto J., Tagawa T., Murata M. (1990). Human dentin-matrix-derived bone morphogenetic protein. J Dent Res 70:171-175. | en_US |
dc.identifier.citedreference | Bimstein E., Shoshan S. (1981). Enhanced healing of tooth-pulp wounds in the dog by enriched collagen solution as a capping agent. Arch Oral Biol 26:97-101. | en_US |
dc.identifier.citedreference | Butler WT, Mikulski A., Urist MR (1977). Non-collagenous proteins of a rat dentin possessing bone morphogenetic activity. I Dent Res 56:228-232. | en_US |
dc.identifier.citedreference | Carmichael DJ, Dick HM, Dodd CM (1974). Histologic effects of antigenically altered collagen as a heterograft for mammalian pulp exposures. Arch Oral Biol 19:1121-1126. | en_US |
dc.identifier.citedreference | Celeste A.), lannazzi JA, Taylor RC, Hewick RM, Rosen V., Wang EA (1990). Identification of transforming growth factor β family members present in bone-inductive protein purified from bovine bone. Proc Natl Acad Sci (USA) 87:9843-9847. | en_US |
dc.identifier.citedreference | Cohen S., Burns RC (1991). Pathways of the pulp. In: Pathways of the pulp. Baltimore: Mosby Year Book Inc., pp. 447-448. | en_US |
dc.identifier.citedreference | Conover MA, Urist MR (1982). Dentin matrix bone morphogenetic protein. In : Proceedings of the 1st International Conference on Chemistry and Biology of Mineralized Connective Tissue. Veis A, editor. New York: Northwestern University, pp. 597-606. | en_US |
dc.identifier.citedreference | D'Souza R., Happonen RP, Ritter NM, Butler WT (1990). Temporal and spatial patterns of transforming growth factor β1 expression in developing rat molars. Arch Oral Biol 35:957-965. | en_US |
dc.identifier.citedreference | D'Souza RN Letterio JJ, Dickinson DP, Roberts AB, Litz M. (1995). Transforming growth factor beta and tooth development (abstract). J Dent Res 74:72. | en_US |
dc.identifier.citedreference | Dick HM, Carmichael DJ (1980). Reconstituted antigen-poor collagen preparations as potential pulp-capping agents. J Endodont 6:641-644. | en_US |
dc.identifier.citedreference | Finkleman RD, Mohan S., Jennings JC, Taylor AK, lepsen S., Baylink DJ (1990). Quantitation of growth factors IGF-1, SGF/IGF-II, and TGF-β in human dentin. J Bone Min Res 5:717-723. | en_US |
dc.identifier.citedreference | Fitzgerald M., Heys RJ (1991). A clinical and histological evaluation of conservative pulpal therapy in human teeth. Oper Dent 16:101-112. | en_US |
dc.identifier.citedreference | Fuks AB, Michaeli Y., Sofer SB, Shoshan S. (1984). Enriched collagen solution as a pulp dressing in pulpotomized teeth in monkeys. Pediatr Dent 6 :243-247. | en_US |
dc.identifier.citedreference | Fuks AB, Cleaton-lones P., Michaeli P., Bimstein E. (1991). Pulp response to collagen and glutaraldehyde in pulpotomized primary teeth of baboons. Pediatr Dent 13:142-150. | en_US |
dc.identifier.citedreference | Glass R., Zander HA (1949). Pulp healing. J Dent Res 28 :97-110. | en_US |
dc.identifier.citedreference | Haskell EW, Stanley HR, Chellemi J., Stringfellow H. (1978). Direct pulp capping treatment: a long term follow-up.) Am Dent Assoc 97:607-612. | en_US |
dc.identifier.citedreference | Hauschka PV, Mavrokos AE, Iafrati MD, Doleman SM, Klagsbrun M. (1986). Growth factors in bone matrix. J Biol Chem 261:12665-12674. | en_US |
dc.identifier.citedreference | Heikinheimo K. (1994). Stage-specific expression of decapentaplegic-Vg-related genes 2, 4, and 6 (bone morphogenetic proteins 2, 4, and 6) during human tooth morphogenesis. J Dent Res 73:590-597. | en_US |
dc.identifier.citedreference | Heikinheimo K., Happonen RP, Miettinen PJ, Ritvos O. (1993). Transforming growth factor β2 in epithelial differentiation of developing teeth and odontogenic tumors. I Clin Invest 91:1019-1027. | en_US |
dc.identifier.citedreference | Heine UI, Munoz EF, Flouners KC, Ellingsworth KR, Lam HYP, Thompson NL, et al. (1987). Role of transforming growth factor-β in development of mouse embryo. I Cell Biol 105:2861-2876. | en_US |
dc.identifier.citedreference | Hess W. (1950). The treatment of teeth with exposed healthy pulps. Int Dent J 1:10-14. | en_US |
dc.identifier.citedreference | Huggins CB, Urist MR (1970). Dentin matrix transformation : rapid induction of alkaline phosphatase and cartilage. Science 167:896-897. | en_US |
dc.identifier.citedreference | Inoue T., Deporter DA, Melcher AH (1986). Induction of chondrogenesis in muscle, skin, bone marrow, and periodontal ligament by demineralized dentin and bone matrix in vivo and in vitro. J Dent Res 65:12-22. | en_US |
dc.identifier.citedreference | lepsen S., Schlitz P., Strong DD, Scharla RH, Snead ML, Finkleman RD (1992). Transforming growth factor-β, m RNA in neonatal ovine molars visualized by in situ hybridization: potential role for the stratum inter-medium. Arch Oral Biol 37:645-653. | en_US |
dc.identifier.citedreference | lohannson BI, Persson I., Manera P. (1963). Histologic effects of collagen and chondroitin sulphate as capping agents in amputated rat molar pulps. Arch Oral Biol 8:503-507. | en_US |
dc.identifier.citedreference | Jones MC, Lyons KM, Hogan BLM (1991). Involvement of bone morphogenetic protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. Development 111:531-542. | en_US |
dc.identifier.citedreference | Joseph BK, Savage NW, Young WG, Gupta GS, Breier BH, Waters MJ (1993). Expression and regulation of insulin-like growth factor-I in the rat incisor. Growth Factors 8:267-275. | en_US |
dc.identifier.citedreference | lowett AK, Vainio S., Ferguson MWJ, Sharpe PT, Thesleff I. (1993). Epithelial-mesenchymal interactions are required for msxl and msx2 gene expression in the developing murine molar tooth. Development 111 :461-470. | en_US |
dc.identifier.citedreference | Kollar E. (1983). Epithelial-mesenchymal interactions in the mammalian integuments. Tooth development as a model for instructive induction. In: Epithelial mesenchymal interactions in development. Sawyer RH, Fallon JF, editors. New York: Praeger Press, pp. 27-56. | en_US |
dc.identifier.citedreference | Lehnert SA, Akhurst RJ (1988). Embryonic expression pattern of TGF-β type 1 RNA suggests both paracrine and autocrine mechanisms of action. Development 104:263-273. | en_US |
dc.identifier.citedreference | Lesot H, Meyer JM, Karcher-Djuricic V, Ahmad N, Staubli A, ldriss H, et al., editors (1985). Tooth morphogenesis and cytodifferentiation. Paris: INSERM. | en_US |
dc.identifier.citedreference | Lesot H., Begue-Kirn C., Kubler MD, Meyer JM, Smith AJ, Cassidy N., et al. (1993). Experimental induction of odontoblast differentiation and stimulation during reparative processes. Cells Mater 3:201-217. | en_US |
dc.identifier.citedreference | Lianjia Y., Yuhao G., White F. (1993). Bovine bone morphogenetic protein induced dentinogenesis. Clin Orthop Rel Res 295:305-312. | en_US |
dc.identifier.citedreference | Linde A., Goldberg M. (1993). Dentinogenesis. Crit Rev Oral Biol Med 4:679-728. | en_US |
dc.identifier.citedreference | Lyons KM, Pelton RW, Hogan BLM (1990). Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). Development 109:833-844. | en_US |
dc.identifier.citedreference | Mac Kenzie A., Leeming GL, Jowett AK, Ferguson MWJ, Sharpe PT (1991). The homeobox gene Hox 7.1 has specific regional and temporal expression patterns during early murine craniofacial embryogenesis, especially tooth development in vivo and in vitro. Development 111:269-285. | en_US |
dc.identifier.citedreference | Mac Kenzie A., Ferguson MWJ, Sharpe PT (1992). Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape. Development 115:403-420. | en_US |
dc.identifier.citedreference | Massagué J. (1990). The transforming growth factor-β family. Ann Rev Cell Biol 6:597-641. | en_US |
dc.identifier.citedreference | Mera K. (1988). Studies on bone morphogenetic protein (BMP) derived from bovine demineralized dentin matrix. J Jpn Stomatol Soc 37:389-399. | en_US |
dc.identifier.citedreference | Miller WA, Sassler M. (1962). Permeability and staining of active and arrested lesions in dentine. Br Dent J 112:187-193. | en_US |
dc.identifier.citedreference | Nakashima M. (1989). Dentin induction by implants of autolyzed antigen-extracted allogenic (AAA) dentin on amputated dental pulps of dogs. Endodont Dent Traumat 5:279-286. | en_US |
dc.identifier.citedreference | Nakashima M. (1990). The induction of reparative dentine in the amputated dental pulp of the dog by bone morphogenetic protein. Arch Oral Biol 35:493-497. | en_US |
dc.identifier.citedreference | Nakashima M. (1994). Induction of dentin formation on canine amputated pulp by recombinant human bone morphogenetic proteins (BMP)-2 and -4. J Dent Res 73:1515-1522. | en_US |
dc.identifier.citedreference | Orvig T. (1967). Early vertebrate calcified tissues. In: Structural and chemical organization of teeth. Miles AEW, editor. London: Academic Press, pp. 45-105. | en_US |
dc.identifier.citedreference | Ozkaynak E., Rueger DC, Drier EA, Corbett C., Ridge RJ, Sampath TK, et al. (1990). OP-1 c DNA encodes an osteogenic protein in the TGF-β family. EMBO J 9:2085-2093. | en_US |
dc.identifier.citedreference | Ozkaynak E., Schnegelsberg PNJ, Jin DF, Clifford GM, Warren FD, Drier EA, et al. (1992). Osteogenic protein-2. J Biol Chem 267:25220-25227. | en_US |
dc.identifier.citedreference | Pashley DH (1985). Dentin-predentin complex and its permeability: pathology and treatment overview.) J Dent Res 64(Spec Iss) :613-620. | en_US |
dc.identifier.citedreference | Pashley DH (1989). Dentin permeability: theory and practice. In: Experimental endodontics. Spangberg L, editor. Boca Raton, FL: CRC Press, pp. 22-36. | en_US |
dc.identifier.citedreference | Pelton RW, Dickinson ME, Moses HL, Hogan BLM (1990). In situ hybridization analysis of TGF-β3 RNA expression during mouse development: comparative studies with TGF-β1 and β2. Development 110:609-620. | en_US |
dc.identifier.citedreference | Piattelli A., Trisi P. (1993). Pulp obliteration: a histological study. J Endodont 19:252-254. | en_US |
dc.identifier.citedreference | Ruch IV (1985). Odontoblast differentiation and the formation of the odontoblast layer. I Dent Res 64:489-498. | en_US |
dc.identifier.citedreference | Rutherford RB, Wahle J., Tucker M., Rueger D., Charette M. (1993). Induction of reparative dentin formation in monkeys by recombinant human osteogenic protein-1. Arch Oral Biol 38:571-576. | en_US |
dc.identifier.citedreference | Rutherford RB, Spangberg L., Tucker M., Rueger D., Charette M. (1994). Time course of the induction of reparative dentin formation in monkeys by recombinant human osteogenic protein-1. Arch Oral Biol 39:833-838. | en_US |
dc.identifier.citedreference | Rutherford RB, Spangberg L., Tucker M., Charette M. (1995). Transdentinal stimulation of reparative dentin formation by osteogenic protein-1. Arch Oral Biol (in press). | en_US |
dc.identifier.citedreference | Sampath TK, Reddi AH (1981). Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. Proc Natl Acad Sci (USA) 78:7599-7603. | en_US |
dc.identifier.citedreference | Sampath TK, Rueger DC (1994). Structure, function and orthopedic applications of osteogenic protein-1 (OP-1). Complications in Orthop (winter):101-107. | en_US |
dc.identifier.citedreference | Sampath TK, Coughlin IE, Whetstone RM, Banach D., Corbett C., Ridge RJ, et al. (1990). Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-β superfamily. J Biol Chem 265:13198-13205. | en_US |
dc.identifier.citedreference | Sampath TK, Maliakal JC, Hauschka PV, Jones WK, Sasak H., Tucker RF, et al. (1992). Recombinant human osteogenic protein-1 (h OP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J Biol Chem 267:20352-20362. | en_US |
dc.identifier.citedreference | Satokata I., Maas R. (1994). Msxl deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Nat Genet 6:348-356. | en_US |
dc.identifier.citedreference | Seltzer S. (1988). Endodontology. 2nd ed. Philadelphia: Lea and Febiger. | en_US |
dc.identifier.citedreference | Seltzer S, Bender IB, editors (1984). Pulp capping and pulpotomy. In: Biologic considerations in dental procedures. Philadelphia: J. B. Lippincott and Co., pp. 281-302. | en_US |
dc.identifier.citedreference | Smith AJ, Tobias RS, Plant CG, Browne RM, Lesot H., Ruch JV (1990). In vivo morphogenetic activity of dentine matrix proteins. J Biol Buccale 18:123-129. | en_US |
dc.identifier.citedreference | Smith AJ, Tobias RS, Cassidy N., Plant CG, Browne RM, Begue-Kirn C., et al. (1994). Odontoblast sitmulation in ferrets by dentine matrix components. Arch Oral Biol 39:13-22 | en_US |
dc.identifier.citedreference | Stanley HR (1989). Pulp capping: conserving the dental pulp-can it be done? Is it worth it? Oral Surg Oral Med Oral Pathol 68:628-639. | en_US |
dc.identifier.citedreference | Takeda K., Oida S., Goseki M., Iimura T., Maruoka Y., Amagasa T., et al. (1994). Expression of bone morphogenetic protein genes in the human dental pulp cells. Bone 15:467-470. | en_US |
dc.identifier.citedreference | Thesleff I., Hurmerinta K. (1981). Tissue interactions in tooth development. Differentiation 18:75-85. | en_US |
dc.identifier.citedreference | Torneck CD (1990). The clinical significance and management of calcific pulp obliteration. Alpha Omegan 83 :50-54. | en_US |
dc.identifier.citedreference | Tronstad L. (1972). Optical and microradiographic appearance of intact and worn human coronal dentin. Arch Oral Biol 17:847-852. | en_US |
dc.identifier.citedreference | Tziafas D., Kolokuris I. (1990). Inductive influences of demineralized dentine and bone matrix on pulp cells: an approach to secondary dentinogenesis. J Dent Res 69 :75-81 | en_US |
dc.identifier.citedreference | Tziafas D., Alvanou A., Kaidoglou K. (1992a). Dentinogenic activity of allogenic plasma fibronectin on dog dental pulp. J Dent Res 71:1189-1195. | en_US |
dc.identifier.citedreference | Tziafas D., Kolokuris I., Alvanou A., Kaidoglou K. (1992b). Short-term dentinogenic response of dog dental pulp tissue after its induction by demineralised or native dentine or predentine. Arch Oral Biol 37:119-128. | en_US |
dc.identifier.citedreference | Urist MR (1965). Bone: Formation by induction. Science 150:893-899. | en_US |
dc.identifier.citedreference | Urist MR (1971). Bone histiogenesis and morphogenesis in implants of demineralized enamel and dentin J Oral Surg 29:88-102. | en_US |
dc.identifier.citedreference | Vaahtokari A., Vainio S., Thesleff I. (1991). Associations between transforming growth factor β1 expression and epithelial-mesenchymal interactions during tooth morphogenesis. Development 113:985-994. | en_US |
dc.identifier.citedreference | Vainio S., Karavanova I., Jowett A., Thesleff I. (1993). Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 75:45-58. | en_US |
dc.identifier.citedreference | Valecillos MEF, Thomas HF, Rutherford RB (1993). Immunolocalization of osteogenic protein (OP-1) in developing murine teeth (abstract). J Dent Res 72:110. | en_US |
dc.identifier.citedreference | Veis A. (1985). The role of dental pulp-thoughts on the session on pulp repair processes. J Dent Res 64:552-554. | en_US |
dc.identifier.citedreference | Wall NA, Blessing M., Wright CVE, Hogan BLM (1993). Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). J Cell Biol 120:493-502. | en_US |
dc.identifier.citedreference | Wang EA, Rosen V., D'Alessandro IS, Bauduy M., Cordes P., Harada T., et al. (1990). Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci (USA) 87:2220-2224. | en_US |
dc.identifier.citedreference | Wise GE, Fan W. (1991). Immunolocalization of transforming growth factor beta in rat molars. J Oral Pathol Med 20:74-80. | en_US |
dc.identifier.citedreference | Wozney JM (1992). The bone morphogenetic protein family and osteogenesis. Molec Reprod Dev 32:160-167. | en_US |
dc.identifier.citedreference | Wozney JM, Rosen V., Celeste AJ, Mitsock LM, Whitters M.), Kriz RW, et al. (1988). Novel regulators of bone formation : molecular clones and activities. Science 242:1528-1534. | en_US |
dc.identifier.citedreference | Yeomans JD, Urist MD (1967). Bone induction by decalcified dentin implanted into oral and muscle tissues. Arch Oral Biol 12:999-1008. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.