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Clinical and Microbiological Aspects of Chemotherapeutic Agents Used According to the Specific Plaque Hypothesis
dc.contributor.authorLoesche, Walter J.en_US
dc.date.accessioned2010-04-13T19:50:24Z
dc.date.available2010-04-13T19:50:24Z
dc.date.issued1979en_US
dc.identifier.citationLoesche, Walter (1979). "Clinical and Microbiological Aspects of Chemotherapeutic Agents Used According to the Specific Plaque Hypothesis." Journal of Dental Research 12(58): 2404-2412. <http://hdl.handle.net/2027.42/67817>en_US
dc.identifier.issn0022-0345en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/67817
dc.description.abstractCertain forms of dental decay and periodontal disease appear to be due to specific bacterial infections following overgrowth of certain indigenous plaque bacteria, i.e., the specific plaque hypothesis. If so, then antimicrobial treatment based on a diagnosis of elevated levels or proportions of these organisms should be considered. Such treatment cannot be administered according to concepts of the non-specific plaque hypothesis. A treatment philosophy is presented which is based upon considerations long established in medical infections following overgrowth of certain indigenous plaque bacteria, i.e., the specific plaque hypo-microbial to the site of the infection for periods long enough to suppress or destroy the pathogenic agent. Examples of this treatment philosophy are given.en_US
dc.format.extent3108 bytes
dc.format.extent738676 bytes
dc.format.mimetypetext/plain
dc.format.mimetypeapplication/pdf
dc.publisherSAGE Publicationsen_US
dc.titleClinical and Microbiological Aspects of Chemotherapeutic Agents Used According to the Specific Plaque Hypothesisen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelDentistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan, School of Dentistry, and School of Medicine, Ann Arbor, Michigan 48109en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/67817/2/10.1177_00220345790580120905.pdf
dc.identifier.doi10.1177/00220345790580120905en_US
dc.identifier.citedreferenceBuin, J.M. and Strahan, J.D.: The Effect of a 1% Chlorhexidine Gel in the Initial Therapy of Chronic Periodontal Disease, J Periodont 49:469-474, 1978.en_US
dc.identifier.citedreferenceBrannstrom, M.; Friskopp, J.; Isacsson, G.; and Wictorin, L.: Experimental Caries in Young Human Permanent Teeth Implanted in Removable Dentures, Arch Oral Biol 22:571-578, 1977.en_US
dc.identifier.citedreferenceBrown, L.R.; Dreizen, S.; and Handler, R.: Effects of Selected Caries Preventive Regimens on Microbial Changes Following Irradiation-induced Xerostomia in Cancer Patients, Proceedings, Microbial Aspects of Dental Caries, Stiles, Loesche and O'Brien, eds., Sp. Supp. Microbiol Abs 275-290, 1976.en_US
dc.identifier.citedreferenceBrudevold, F. and Mc Cann, H.G. : Fluoride and Caries Control. Mechanism of Action. The Science of Nutrition and its Application in Clinical Dentistry, Philadelphia : Saunders, 1966, pp. 331-347.en_US
dc.identifier.citedreferenceEmilson, C.G. and Fornell, J. Effect of Toothbrushing with Chlorhexidine Gel on Salivary Microflora, Oral Hygiene, and Caries, Scand J Dent Res 84:308-319, 1976.en_US
dc.identifier.citedreferenceEnright, J.J. ; Friesell, H.E.; and Trescher, M. 0.: Studies on the Cause and Nature of Dental Caries, J Dent Res 12:759-851, 1932.en_US
dc.identifier.citedreferenceFlotra, L.; Gjermo, P.; Rlla, G.; and Waerhaug, J.: A Four-month Study on the Effect of Chlorhexidine Mouthwashes on 50 Soldiers, Scand J Dent Res 80:10-15, 1972.en_US
dc.identifier.citedreferenceGibbons, R.J. and Van Houte, J.: On the Formation of Dental Plaque, J Periodont 44:347-360, 1973.en_US
dc.identifier.citedreferenceHamilton, I. R.: Effects of Fluoride on Enzymatic Regulation of Bacterial Carbohydrate Metabolism. In: Cariostatic Mechanisms of Fluorides, Caries Res 11 (Suppl.): 321-327, 1977.en_US
dc.identifier.citedreferenceHamp, L.E. and Emilson, C.G.: Some Effects of Chlorhexidine on the Plaque Flora of the Beagle Dog, J Periodont Res 8:(Suppl.) 28-40, 1973.en_US
dc.identifier.citedreferenceHodge, H.C.: Fluoride Toxicity. In: Fluorides and Dental Caries, Springfield, IL: E. Newbrun, C. C. Thomas, ed., 1975, pp. 138-146.en_US
dc.identifier.citedreferenceIrving, J.T. ; Socransky, S.S.; Newman, M.G.; and Savit, E.: Periodontal Destruction Induced by Capnocytophaga in Gnotobiotic Rats, IADR Progr & Abst 55:No. 783, 1976.en_US
dc.identifier.citedreferenceJordan, H.V. and De Paola, P.: Effect of Prolonged Topical Application of Vancomycin on Human Oral Streptococcus mutans Populations, Arch Oral Biol 22:193-200, 1977.en_US
dc.identifier.citedreferenceJordan, H.V. ; Keyes, P.H.; and Bellock, B.: Periodontal Lesions in Hamsters and Gnotobiotic Rats Infected with Actinomyces of Human Origin, J Periodont Res 7:21-25, 1972.en_US
dc.identifier.citedreferenceKeyes, P.H. : The Infections and Transmissible Nature of Experimental Dental Caries: Findings and Implications, Arch Oral Biol 1:304-310, 1960.en_US
dc.identifier.citedreferenceKeyes, P.H. : Present and Future Measures for Dental Caries Control, JADA 79 :1395-1404, 1969.en_US
dc.identifier.citedreferenceLevine, R.S. : Distribution of Fluoride in Active and Arrested Carious Lesions in Dentin, J Dent Res 51:1025-1029, 1972.en_US
dc.identifier.citedreferenceLöe, H. : Human Research Model for the Production and Prevention of Gingivitis, J Dent Res 50:256-265, 1971.en_US
dc.identifier.citedreferenceLöe, H. and Schiott, C.R.: The Effect of Mouthrinses and Topical Application Chlorhexidine on the Development of Dental Plaque and Gingivitis in Man, J Periodont Res 5:79-84, 1970.en_US
dc.identifier.citedreferenceLoesche, W.J. : Chemotherapy of Dental Plaque Infections, Oral Sci Rev 9:63-105, 1976.en_US
dc.identifier.citedreferenceLoesche, W.J. and Syed, S.A.: Bacteriology of Human Experimental Gingivitis. II. Effect of Plaque and Gingivitis Score, Infect and Immun 21:830-839, 1978.en_US
dc.identifier.citedreferenceLoesche, W.J. ; Bradbury, D.R.; and Woolfolk, M.P.: Reduction of Dental Decay in Rampant Caries Individuals Following Short Kanamycin Treatment, J Dent Res 56:254-265, 1977.en_US
dc.identifier.citedreferenceLoesche, W.J. ; Murray, R.J.; and Mellberg, J.R.: The Effect of Topical Fluoride on Percentages of Streptococcus mutans and Streptococcus sanguis in Interproximal Plaque, Caries Res 7:283-296, 1973.en_US
dc.identifier.citedreferenceLoesche, W.J. ; Rowan, J.; Straffon, L.H.; and Loos, P.J.: The Association of Streptococcus mutans with Human Dental Decay, Infect and Immunol 11:1252-1260, 1975.en_US
dc.identifier.citedreferenceMacdonald, J.B.; Socransky, S.S.; Gibbons, R.J.: Aspects of the Pathogenesis of Mixed Anaerobic Infections of Mucous Membranes, J Dent Res 42:529-534, 1963.en_US
dc.identifier.citedreferenceMyers, H.M.: The Mechanism of the Anticaries Action of Fluoride Ion. In: Fluorides and Dental Caries, E. Newbrun, ed., Springfield, IL: C. C. Thomas, 1975, pp. 99-112.en_US
dc.identifier.citedreferenceMuhlemann, H.R. and Son, S.: Gingival Sulcus Bleeding - A Leading Symptom in Initial Gingivitis, Helv Odont Acta IS: 107-113, 1971.en_US
dc.identifier.citedreferenceNewman, M.G. and Socransky, S.S.: Predominant Cultivable Microbiota in Periodontosis, J Periodont Res 12:120-128, 1977.en_US
dc.identifier.citedreferenceRlla, G.; Löe, H.; and Schiott, R.: Retention of Chlorhexidine in Human Oral Cavity, Arch Oral Biol 16:1109-1115, 1970.en_US
dc.identifier.citedreferenceRussell, B.C. and Bay, L.M.: Oral Use of Chlorhexidine Gluconate Toothpaste in Epileptic Children, Scand J Dent Res 86: 52-57, 1978.en_US
dc.identifier.citedreferenceSlots, J.: The Predominant Cultivable Microflora of Advanced Periodontitis, Scand J Dent Res 85:114-121, 1977.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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