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Quantitative Microscopy of Hepatic Changes Induced by Phenethyl Isothiocyanate in Fischer-344 Rats Fed Either a Cereal-Based Diet or a Purified Diet
dc.contributor.authorGray, Roberten_US
dc.contributor.authorAdam-Rodwell, Gabrielaen_US
dc.contributor.authorMaris, Dorinaen_US
dc.contributor.authorHaskins, Jeffreyen_US
dc.contributor.authorStoner, Garyen_US
dc.date.accessioned2010-04-14T13:42:10Z
dc.date.available2010-04-14T13:42:10Z
dc.date.issued1995en_US
dc.identifier.citationGray, Robert; Adam-Rodwell, Gabriela; Maris, Dorina; Haskins, Jeffrey; Stoner, Gary (1995). "Quantitative Microscopy of Hepatic Changes Induced by Phenethyl Isothiocyanate in Fischer-344 Rats Fed Either a Cereal-Based Diet or a Purified Diet." Toxicologic Pathology 23(6): 644-652. <http://hdl.handle.net/2027.42/68493>en_US
dc.identifier.issn0192-6233en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/68493
dc.description.abstractHepatic changes induced by phenethyl isothiocyanate (PEITC) in the liver of rats were determined by quantitative microscopy. Groups of male Fischer-344 rats were fed either a standard, cereal-based diet (Wayne rodent meal) or a purified diet (AIN-76A) containing PEITC at concentrations of 0.75 and 6.0 mmol/kg for 13 wk. Severe hepatic lipidosis was observed in control rats fed the purified diet. Addition of PEITC to the purified diet significantly reduced lipid content in hepatocytes. In contrast, lipid content in the liver of the rats fed the cereal-based diet containing PEITC was greater than in control rats maintained on the same diet. In addition, dose-related reductions in hepatocyte, lipid droplet, peroxisome, and mitochondrial volumes were observed in PEITC-treated rats fed the cereal-based diet. These results indicate that PEITC exerts differential effects on the liver of rats fed either the cereal-based or purified diet.en_US
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dc.publisherSage Publicationsen_US
dc.subject.otherMorphometric Analysisen_US
dc.subject.otherAIN-76A Purified Dieten_US
dc.subject.otherHepatic Fatty Changeen_US
dc.subject.otherLiveren_US
dc.subject.otherRaten_US
dc.titleQuantitative Microscopy of Hepatic Changes Induced by Phenethyl Isothiocyanate in Fischer-344 Rats Fed Either a Cereal-Based Diet or a Purified Dieten_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPathologyen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Environmental and Industrial Health, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumDepartment of Environmental and Industrial Health, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumDepartment of Environmental and Industrial Health, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationotherDepartment of Pathology, Medical College of Ohio, Toledo, Ohio 43699en_US
dc.contributor.affiliationotherDepartment of Pathology, Medical College of Ohio, Toledo, Ohio 43699en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/68493/2/10.1177_019262339502300602.pdf
dc.identifier.doi10.1177/019262339502300602en_US
dc.identifier.sourceToxicologic Pathologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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