Mechanical, permeability, and degradation properties of 3D designed poly(1,8 octanediol- co -citrate) scaffolds for soft tissue engineering
dc.contributor.author | Jeong, Claire G. | en_US |
dc.contributor.author | Hollister, Scott J. | en_US |
dc.date.accessioned | 2010-04-14T20:02:18Z | |
dc.date.available | 2011-03-01T16:26:43Z | en_US |
dc.date.issued | 2010-04 | en_US |
dc.identifier.citation | Jeong, Claire G.; Hollister, Scott J. (2010). "Mechanical, permeability, and degradation properties of 3D designed poly(1,8 octanediol- co -citrate) scaffolds for soft tissue engineering." Journal of Biomedical Materials Research Part B: Applied Biomaterials 93B(1): 141-149. <http://hdl.handle.net/2027.42/69170> | en_US |
dc.identifier.issn | 1552-4973 | en_US |
dc.identifier.issn | 1552-4981 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/69170 | |
dc.description.abstract | Poly(1,8-octanediol- co -citric acid) (POC) is a synthetic biodegradable elastomer that can be processed into three-dimensional (3D) scaffolds for tissue engineering. We investigated the effect of designed porosity on the mechanical properties, permeability, and degradation profiles of the POC scaffolds. For mechanical properties, scaffold compressive data were fitted to a one-dimensional (1D) nonlinear elastic model, and solid tensile data were fitted to a Neohookean incompressible nonlinear elastic model. Chondrocytes were seeded on scaffolds to assess the biocompatibility of POC. Increased porosity was associated with increased degradation rate, increased permeability, and decreased mechanical stiffness, which also became less nonlinear. Scaffold characterization in this article will provide design guidance for POC scaffolds to meet the mechanical and biological parameters needed for engineering soft tissues such as cartilage. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010 | en_US |
dc.format.extent | 507611 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Mechanical, permeability, and degradation properties of 3D designed poly(1,8 octanediol- co -citrate) scaffolds for soft tissue engineering | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109-2125 | en_US |
dc.contributor.affiliationum | Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109-2125 ; Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109-2125 ; Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109-0329 ; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109-2125 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/69170/1/31568_ftp.pdf | |
dc.identifier.doi | 10.1002/jbm.b.31568 | en_US |
dc.identifier.source | Journal of Biomedical Materials Research Part B: Applied Biomaterials | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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