NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults
dc.contributor.author | Amstadter, Ananda B. | en_US |
dc.contributor.author | Koenen, Karestan C. | en_US |
dc.contributor.author | Ruggiero, Kenneth J. | en_US |
dc.contributor.author | Acierno, Ron | en_US |
dc.contributor.author | Galea, Sandro | en_US |
dc.contributor.author | Kilpatrick, Dean G. | en_US |
dc.contributor.author | Gelernter, Joel | en_US |
dc.date.accessioned | 2010-04-14T20:02:23Z | |
dc.date.available | 2011-03-01T16:26:43Z | en_US |
dc.date.issued | 2010-03 | en_US |
dc.identifier.citation | Amstadter, Ananda B.; Koenen, Karestan C.; Ruggiero, Kenneth J.; Acierno, Ron; Galea, Sandro; Kilpatrick, Dean G.; Gelernter, Joel (2010). " NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults." Depression and Anxiety 27(3): 270-275. <http://hdl.handle.net/2027.42/69171> | en_US |
dc.identifier.issn | 1091-4269 | en_US |
dc.identifier.issn | 1520-6394 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/69171 | |
dc.description.abstract | Background : Neuropeptide Y (NPY) has been found to be anxiolytic in animals and humans. A recent study found NPY expression to be inversely correlated with trait anxiety. We examined whether rs16147, a functional single nucleotide polymorphism in the promoter region of NPY, moderated the relationship between hurricane exposure and risk for generalized anxiety disorder (GAD) in an epidemiologic sample of adults living in areas affected by the 2004 Florida Hurricanes. Methods : Data from this study comes from 616 adults from the 2004 Florida Hurricanes study who returned buccal DNA samples via mail. Selection of participants occurred via random digit-dial procedures. Participants were interviewed via telephone about hurricane exposure and posthurricane GAD symptoms. The outcome measure was DSM-IV GAD diagnosis, assessed via structured interview. Results : Rs16147 in NPY was associated with increased risk of GAD diagnosis under conditions of high hurricane exposure (P<.01). This gene by environment interaction remained significant after adjustment for sex, ancestry (as determined by Bayesian clustering of genotypes), and age. Conclusions : NPY rs16147 modifies risk of postdisaster GAD under conditions of high stressor (hurricane) exposure. This is the first demonstration of gene–environment interaction for this locus. Depression and Anxiety, 2010. © 2009 Wiley-Liss, Inc. | en_US |
dc.format.extent | 105463 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology and Institute for Social Research, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina ; 67 President Street, 2nd Floor South, Charleston, SC 29425 | en_US |
dc.contributor.affiliationother | Departments of Society, Human Development and Health and Epidemiology, Harvard School of Public Health, Boston, Massachusetts | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina | en_US |
dc.contributor.affiliationother | Departments of Psychiatry, Genetics, and Neurobiology, Yale University School of Medicine, New Haven, Connecticut | en_US |
dc.identifier.pmid | 20037921 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/69171/1/20648_ftp.pdf | |
dc.identifier.doi | 10.1002/da.20648 | en_US |
dc.identifier.source | Depression and Anxiety | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.