Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome
dc.contributor.author | Reimer, Thornik | en_US |
dc.contributor.author | Shaw, Michael H. | en_US |
dc.contributor.author | Franchi, Luigi | en_US |
dc.contributor.author | Coban, Cevayir | en_US |
dc.contributor.author | Ishii, Ken J. | en_US |
dc.contributor.author | Akira, Shizuo | en_US |
dc.contributor.author | Horii, Toshihiro | en_US |
dc.contributor.author | Rodriguez, Ana | en_US |
dc.contributor.author | Núñez, Gabriel | en_US |
dc.date.accessioned | 2010-04-14T20:04:23Z | |
dc.date.available | 2011-03-01T16:26:44Z | en_US |
dc.date.issued | 2010-03 | en_US |
dc.identifier.citation | Reimer, Thornik; Shaw, Michael H.; Franchi, Luigi; Coban, Cevayir; Ishii, Ken J.; Akira, Shizuo; Horii, Toshihiro; Rodriguez, Ana; NÚÑez, Gabriel (2010). "Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome." European Journal of Immunology 40(3): 764-769. <http://hdl.handle.net/2027.42/69193> | en_US |
dc.identifier.issn | 0014-2980 | en_US |
dc.identifier.issn | 1521-4141 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/69193 | |
dc.description.abstract | Cerebral malaria is the most severe complication of Plasmodium falciparum infection in humans and the pathogenesis is still unclear. Using the P. berghei ANKA infection model of mice, we investigated a potential involvement of Nlrp3 and the inflammasome in the pathogenesis of cerebral malaria. Nlrp3 mRNA expression was upregulated in brain endothelial cells after exposure to P. berghei ANKA. Although Β-hematin, a synthetic compound of the parasites heme polymer hemozoin, induced the release of IL-1Β in macrophages through Nlrp3, we did not obtain evidence for a role of IL-1Β in vivo . Nlrp3 knock-out mice displayed a delayed onset of cerebral malaria; however, mice deficient in caspase-1, the adaptor protein ASC or the IL-1 receptor succumbed as WT mice. These results indicate that the role of Nlrp3 in experimental cerebral malaria is independent of the inflammasome and the IL-1 receptor pathway. | en_US |
dc.format.extent | 242250 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Microbiology and Immunology | en_US |
dc.title | Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA ; Paul H. Dekruif Professor of Pathology, University of Michigan Medical School, 1500 E. Medical Center Dr, 4215 CCGC, Ann Arbor, MI 48109, USA Fax: +1-734-647-9654 | en_US |
dc.contributor.affiliationother | Laboratory of Host Defense, Immunology Frontier Research Center, World Premier Immunology Institute, Osaka University, Osaka, Japan | en_US |
dc.contributor.affiliationother | Laboratory of Host Defense, Immunology Frontier Research Center, World Premier Immunology Institute, Osaka University, Osaka, Japan ; Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan | en_US |
dc.contributor.affiliationother | Laboratory of Host Defense, Immunology Frontier Research Center, World Premier Immunology Institute, Osaka University, Osaka, Japan | en_US |
dc.contributor.affiliationother | Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan | en_US |
dc.contributor.affiliationother | Department of Medical Parasitology, New York University School of Medicine, New York, NY, USA | en_US |
dc.identifier.pmid | 19950187 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/69193/1/764_ftp.pdf | |
dc.identifier.doi | 10.1002/eji.200939996 | en_US |
dc.identifier.source | European Journal of Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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