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A continuous flow probe method for on‐line introduction of liquid samples for detection by laser desorption with resonant two‐photon ionization in supersonic beam mass spectrometry
dc.contributor.authorLustig, David A.en_US
dc.contributor.authorLubman, David M.en_US
dc.date.accessioned2010-05-06T22:24:55Z
dc.date.available2010-05-06T22:24:55Z
dc.date.issued1991-04en_US
dc.identifier.citationLustig, David A.; Lubman, David M. (1991). "A continuous flow probe method for on‐line introduction of liquid samples for detection by laser desorption with resonant two‐photon ionization in supersonic beam mass spectrometry." Review of Scientific Instruments 62(4): 957-962. <http://hdl.handle.net/2027.42/70599>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/70599
dc.description.abstractA continuous flow probe is used as a direct inlet source for injection of liquid samples into a time‐of‐flight (TOF) mass spectrometer. The direct liquid inlet is coupled to laser desorption as a means of rapidly vaporizing the nonvolatile sample dissolved in the solvent for entrainment into a supersonic jet expansion. The target analyte is then selectively analyzed by resonance enhanced multiphoton ionization (REMPI) in the TOF device. This method demonstrates the ability to continuously inject thermally labile biological samples such as neurotransmitters and oligopeptides for detection and structural analysis by REMPI. In addition, sensitivity limits in the low ng regime are demonstrated with quantitation over 3 orders of magnitude.en_US
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dc.publisherThe American Institute of Physicsen_US
dc.rights© The American Institute of Physicsen_US
dc.titleA continuous flow probe method for on‐line introduction of liquid samples for detection by laser desorption with resonant two‐photon ionization in supersonic beam mass spectrometryen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/70599/2/RSINAK-62-4-957-1.pdf
dc.identifier.doi10.1063/1.1141984en_US
dc.identifier.sourceReview of Scientific Instrumentsen_US
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dc.owningcollnamePhysics, Department of


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