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HPV-positive/p16-positive/EBV-negative nasopharyngeal carcinoma in white North Americans

dc.contributor.authorMaxwell, Jessica H.en_US
dc.contributor.authorKumar, Bhavnaen_US
dc.contributor.authorFeng, Felix Y.en_US
dc.contributor.authorMcHugh, Jonathan B.en_US
dc.contributor.authorCordell, Kitrina G.en_US
dc.contributor.authorEisbruch, Avrahamen_US
dc.contributor.authorWorden, Francis P.en_US
dc.contributor.authorWolf, Gregory T.en_US
dc.contributor.authorPrince, Mark E. P.en_US
dc.contributor.authorMoyer, Jeffrey S.en_US
dc.contributor.authorTeknos, Theodoros N.en_US
dc.contributor.authorChepeha, Douglas B.en_US
dc.contributor.authorStoerker, Jayen_US
dc.contributor.authorWalline, Heatheren_US
dc.contributor.authorCarey, Thomas E.en_US
dc.contributor.authorBradford, Carol R.en_US
dc.date.accessioned2010-05-07T18:06:53Z
dc.date.available2011-03-01T16:26:45Zen_US
dc.date.issued2010-05en_US
dc.identifier.citationMaxwell, Jessica H.; Kumar, Bhavna; Feng, Felix Y.; McHugh, Jonathan B.; Cordell, Kitrina G.; Eisbruch, Avraham; Worden, Francis P.; Wolf, Gregory T.; Prince, Mark E.; Moyer, Jeffrey S.; Teknos, Theodoros N.; Chepeha, Douglas B.; Stoerker, Jay; Walline, Heather; Carey, Thomas E.; Bradford, Carol R. (2010). "HPV-positive/p16-positive/EBV-negative nasopharyngeal carcinoma in white North Americans." Head & Neck 32(5): 562-567. <http://hdl.handle.net/2027.42/71364>en_US
dc.identifier.issn1043-3074en_US
dc.identifier.issn1097-0347en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/71364
dc.description.abstractBackground Human papillomavirus (HPV) has been detected in keratinizing nasopharyngeal carcinomas (NPCs); however, the relationship between HPV and Epstein–Barr virus (EBV) among whites with nonkeratinizing NPCs remains unclear. The HPV, p16, and EBV status was examined in current University of Michigan patients with NPC. Methods From 2003 to 2007, 89 patients, 84 with oropharyngeal cancer (OPC) and 5 with NPC, were enrolled in an organ-sparing trial. Biopsy tissues from all 89 patients were evaluated for HPV and p16 expression. A separate HPV analysis of the 84 OPC patients is in progress. Among the patients with NPC, tumor tissue was also analyzed for EBV-encoded RNA (EBER). Results Five of 89 patients (5.6%) had NPC, all with nonkeratinizing histology. The 4 white patients with NPC were HPV(+) (subtype-16, subtype-18 [2 patients], and subtype-59)/p16(+)/EBER(-). One Asian patient with NPC had an HPV(-)/p16(-)/EBER(+) NPC tumor that developed distant metastases. Conclusion We postulate that HPV may be the etiologic factor in some EBV-negative, nonkeratinizing NPCs among whites. © 2009 Wiley Periodicals, Inc. Head Neck, 2010en_US
dc.format.extent197169 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCancer Research, Oncology and Pathologyen_US
dc.titleHPV-positive/p16-positive/EBV-negative nasopharyngeal carcinoma in white North Americansen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOtolaryngologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan Medical School, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI ; Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PAen_US
dc.contributor.affiliationumDepartments of Otolaryngology–Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI ; Department of Otolaryngology/Head and Neck Surgery, Ohio State University, Columbus, OHen_US
dc.contributor.affiliationumRadiation Oncology, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MIen_US
dc.contributor.affiliationumPathology, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MIen_US
dc.contributor.affiliationumPathology, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI ; Periodontics and Oral Medicine, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MIen_US
dc.contributor.affiliationumRadiation Oncology, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MIen_US
dc.contributor.affiliationumInternal Medicine, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Otolaryngology–Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Otolaryngology–Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Otolaryngology–Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI ; Department of Otolaryngology/Head and Neck Surgery, Ohio State University, Columbus, OHen_US
dc.contributor.affiliationumDepartments of Otolaryngology–Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Otolaryngology–Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI ; Pharmacology, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI ; Departments of Otolaryngology-Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Otolaryngology–Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MIen_US
dc.contributor.affiliationotherDepartment of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PAen_US
dc.contributor.affiliationotherSensiGen, LLC, Ann Arbor, MI; Sequenom, Inc, San Diego, CAen_US
dc.contributor.affiliationotherSensiGen, LLC, Ann Arbor, MI; Sequenom, Inc, San Diego, CAen_US
dc.identifier.pmid19757421en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/71364/1/21216_ftp.pdf
dc.identifier.doi10.1002/hed.21216en_US
dc.identifier.sourceHead & Necken_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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