HPV-positive/p16-positive/EBV-negative nasopharyngeal carcinoma in white North Americans
dc.contributor.author | Maxwell, Jessica H. | en_US |
dc.contributor.author | Kumar, Bhavna | en_US |
dc.contributor.author | Feng, Felix Y. | en_US |
dc.contributor.author | McHugh, Jonathan B. | en_US |
dc.contributor.author | Cordell, Kitrina G. | en_US |
dc.contributor.author | Eisbruch, Avraham | en_US |
dc.contributor.author | Worden, Francis P. | en_US |
dc.contributor.author | Wolf, Gregory T. | en_US |
dc.contributor.author | Prince, Mark E. P. | en_US |
dc.contributor.author | Moyer, Jeffrey S. | en_US |
dc.contributor.author | Teknos, Theodoros N. | en_US |
dc.contributor.author | Chepeha, Douglas B. | en_US |
dc.contributor.author | Stoerker, Jay | en_US |
dc.contributor.author | Walline, Heather | en_US |
dc.contributor.author | Carey, Thomas E. | en_US |
dc.contributor.author | Bradford, Carol R. | en_US |
dc.date.accessioned | 2010-05-07T18:06:53Z | |
dc.date.available | 2011-03-01T16:26:45Z | en_US |
dc.date.issued | 2010-05 | en_US |
dc.identifier.citation | Maxwell, Jessica H.; Kumar, Bhavna; Feng, Felix Y.; McHugh, Jonathan B.; Cordell, Kitrina G.; Eisbruch, Avraham; Worden, Francis P.; Wolf, Gregory T.; Prince, Mark E.; Moyer, Jeffrey S.; Teknos, Theodoros N.; Chepeha, Douglas B.; Stoerker, Jay; Walline, Heather; Carey, Thomas E.; Bradford, Carol R. (2010). "HPV-positive/p16-positive/EBV-negative nasopharyngeal carcinoma in white North Americans." Head & Neck 32(5): 562-567. <http://hdl.handle.net/2027.42/71364> | en_US |
dc.identifier.issn | 1043-3074 | en_US |
dc.identifier.issn | 1097-0347 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/71364 | |
dc.description.abstract | Background Human papillomavirus (HPV) has been detected in keratinizing nasopharyngeal carcinomas (NPCs); however, the relationship between HPV and Epstein–Barr virus (EBV) among whites with nonkeratinizing NPCs remains unclear. The HPV, p16, and EBV status was examined in current University of Michigan patients with NPC. Methods From 2003 to 2007, 89 patients, 84 with oropharyngeal cancer (OPC) and 5 with NPC, were enrolled in an organ-sparing trial. Biopsy tissues from all 89 patients were evaluated for HPV and p16 expression. A separate HPV analysis of the 84 OPC patients is in progress. Among the patients with NPC, tumor tissue was also analyzed for EBV-encoded RNA (EBER). Results Five of 89 patients (5.6%) had NPC, all with nonkeratinizing histology. The 4 white patients with NPC were HPV(+) (subtype-16, subtype-18 [2 patients], and subtype-59)/p16(+)/EBER(-). One Asian patient with NPC had an HPV(-)/p16(-)/EBER(+) NPC tumor that developed distant metastases. Conclusion We postulate that HPV may be the etiologic factor in some EBV-negative, nonkeratinizing NPCs among whites. © 2009 Wiley Periodicals, Inc. Head Neck, 2010 | en_US |
dc.format.extent | 197169 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | HPV-positive/p16-positive/EBV-negative nasopharyngeal carcinoma in white North Americans | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI ; Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA | en_US |
dc.contributor.affiliationum | Departments of Otolaryngology–Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI ; Department of Otolaryngology/Head and Neck Surgery, Ohio State University, Columbus, OH | en_US |
dc.contributor.affiliationum | Radiation Oncology, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Pathology, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Pathology, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI ; Periodontics and Oral Medicine, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Radiation Oncology, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Internal Medicine, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Otolaryngology–Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Otolaryngology–Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Otolaryngology–Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI ; Department of Otolaryngology/Head and Neck Surgery, Ohio State University, Columbus, OH | en_US |
dc.contributor.affiliationum | Departments of Otolaryngology–Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Otolaryngology–Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI ; Pharmacology, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI ; Departments of Otolaryngology-Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Otolaryngology–Head and Neck Surgery, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA | en_US |
dc.contributor.affiliationother | SensiGen, LLC, Ann Arbor, MI; Sequenom, Inc, San Diego, CA | en_US |
dc.contributor.affiliationother | SensiGen, LLC, Ann Arbor, MI; Sequenom, Inc, San Diego, CA | en_US |
dc.identifier.pmid | 19757421 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/71364/1/21216_ftp.pdf | |
dc.identifier.doi | 10.1002/hed.21216 | en_US |
dc.identifier.source | Head & Neck | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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