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The Future of Aminoglycosides: The End or Renaissance?

dc.contributor.authorHoughton , Jacob L.en_US
dc.contributor.authorGreen, Keith D.en_US
dc.contributor.authorChen , Wenjingen_US
dc.contributor.authorGarneau-Tsodikova, Sylvieen_US
dc.date.accessioned2010-05-07T18:07:05Z
dc.date.available2011-03-01T16:26:45Zen_US
dc.date.issued2010-05-03en_US
dc.identifier.citationHoughton , Jacob L.; Green, Keith D.; Chen , Wenjing; Garneau-Tsodikova , Sylvie (2010). "The Future of Aminoglycosides: The End or Renaissance?." ChemBioChem 11(7): 880-902. <http://hdl.handle.net/2027.42/71366>en_US
dc.identifier.issn1439-4227en_US
dc.identifier.issn1439-7633en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/71366
dc.description.abstractAlthough aminoglycosides have been used as antibacterials for decades, their use has been hindered by their inherent toxicity and the resistance that has emerged to these compounds. It seems that such issues have relegated a formerly front-line class of antimicrobials to the proverbial back shelf. However, recent advances have demonstrated that novel aminoglycosides have a potential to overcome resistance as well as to be used to treat HIV-1 and even human genetic disorders, with abrogated toxicity. It is not the end for aminoglycosides, but rather, the challenges faced by researchers have led to ingenuity and a change in how we view this class of compounds, a renaissance.en_US
dc.format.extent1281094 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWILEY-VCH Verlagen_US
dc.subject.otherChemistryen_US
dc.subject.otherBiochemistry and Biotechnologyen_US
dc.titleThe Future of Aminoglycosides: The End or Renaissance?en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Medicinal Chemistry in the College of Pharmacy, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 (USA), Fax: (+1) 734-615-5521 ; Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 (USA)en_US
dc.contributor.affiliationumLife Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 (USA)en_US
dc.contributor.affiliationumChemical Biology Doctoral Program, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 (USA) ; Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 (USA)en_US
dc.contributor.affiliationumDepartment of Medicinal Chemistry in the College of Pharmacy, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 (USA), Fax: (+1) 734-615-5521 ; Chemical Biology Doctoral Program, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 (USA) ; Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 (USA)en_US
dc.identifier.pmid20397253en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/71366/1/880_ftp.pdf
dc.identifier.doi10.1002/cbic.200900779en_US
dc.identifier.sourceChemBioChemen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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