CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DC
dc.contributor.author | Kallal, Lara Elizabeth | en_US |
dc.contributor.author | Schaller, Matthew A. | en_US |
dc.contributor.author | Lindell, Dennis M. | en_US |
dc.contributor.author | Lira, Sergio A. | en_US |
dc.contributor.author | Lukacs, Nicholas W. | en_US |
dc.date.accessioned | 2010-05-07T18:07:46Z | |
dc.date.available | 2011-03-01T16:26:45Z | en_US |
dc.date.issued | 2010-04 | en_US |
dc.identifier.citation | Kallal, Lara E.; Schaller, Matthew A.; Lindell, Dennis M.; Lira, Sergio A.; Lukacs, Nicholas W. (2010). "CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DC." European Journal of Immunology 40(4): 1042-1052. <http://hdl.handle.net/2027.42/71373> | en_US |
dc.identifier.issn | 0014-2980 | en_US |
dc.identifier.issn | 1521-4141 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/71373 | |
dc.description.abstract | Chemokines are important mediators of the immune response to pathogens, but can also promote chronic inflammatory states. Chemokine receptor 6 (CCR6) is found on immature DC and effector/memory T cells, and binds a single ligand, CCL20, with high affinity. Here, we investigated the role of CCL20 and CCR6 in a pulmonary viral infection caused by RSV, a ubiquitous virus that can cause severe pulmonary complications. Neutralization of CCL20 during RSV infection significantly reduced lung pathology and favored a Th1 effector response. CCR6-deficient animals recapitulated this phenotype, and additionally showed enhanced viral clearance when compared with WT mice. No differences were observed in migration of T cells to the lungs of CCR6 −/− animals; however, a significant reduction was observed in numbers of conventional DC (cDC), but not plasmacytoid DC, in CCR6 −/− mice. A pathogenic phenotype could be reconstituted in CCR6 −/− mice by supplying cDC into the airway, indicating that mere number of cDC dictates the adverse response. Our data suggest that blockade of the CCL20/CCR6 pathway provides an environment whereby the attenuated recruitment of cDC alters the balance of innate immune cells and mediates the efficient antiviral response to RSV. | en_US |
dc.format.extent | 589621 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Microbiology and Immunology | en_US |
dc.title | CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DC | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Molecular & Cellular Pathology, The University of Michigan, Ann Arbor, MI, USA ; The University of Michigan, 109 Zina Pitcher Place, 4620 BSRB, Ann Arbor, MI 48109, USA Fax: +1-734-615-0642 | en_US |
dc.contributor.affiliationum | Department of Molecular & Cellular Pathology, The University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Molecular & Cellular Pathology, The University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Molecular & Cellular Pathology, The University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Immunobiology Center, Mount Sinai School of Medicine, New York, NY, USA | en_US |
dc.identifier.pmid | 20101616 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/71373/1/1042_ftp.pdf | |
dc.identifier.doi | 10.1002/eji.200939778 | en_US |
dc.identifier.source | European Journal of Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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