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GATA-1 testis activation region is essential for Sertoli cell-specific expression of GATA-1 gene in transgenic mouse
dc.contributor.authorWakabayashi, Junkoen_US
dc.contributor.authorYomogida, Kentaroen_US
dc.contributor.authorNakajima, Osamuen_US
dc.contributor.authorYoh, Keigyouen_US
dc.contributor.authorTakahashi, Satoruen_US
dc.contributor.authorEngel, James Douglasen_US
dc.contributor.authorOhneda, Kinukoen_US
dc.contributor.authorYamamoto, Masayukien_US
dc.date.accessioned2010-06-01T18:10:54Z
dc.date.available2010-06-01T18:10:54Z
dc.date.issued2003-07en_US
dc.identifier.citationWakabayashi, Junko; Yomogida, Kentaro; Nakajima, Osamu; Yoh, Keigyou; Takahashi, Satoru; Engel, James Douglas; Ohneda, Kinuko; Yamamoto, Masayuki (2003). "GATA-1 testis activation region is essential for Sertoli cell-specific expression of GATA-1 gene in transgenic mouse." Genes to Cells 8(7): 619-630. <http://hdl.handle.net/2027.42/71393>en_US
dc.identifier.issn1356-9597en_US
dc.identifier.issn1365-2443en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/71393
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12839622&dopt=citationen_US
dc.description.abstractBackground: The erythroid transcription factor GATA-1 is also expressed in Sertoli cells of the testis. The testicular expression of GATA-1 is regulated in a developmental and spermatogenic stage-specific manner. To further clarify the regulatory mechanisms of testicular GATA-1 gene expression, we carried out transgenic reporter gene expression analyses. Results: We found that GATA-1 expression in Sertoli cells is markedly decreased concomitant with the emergence of elongated spermatids in the seminiferous tubules. Transgenic reporter mouse analyses revealed that a 15 kb GATA-1 genomic region is sufficient to recapitulate the gene expression profile in Sertoli cells. While the GATA-1 haematopoietic enhancer and the proximal first exon are included within the 15 kb genomic region, these regulatory elements are not essential for GATA-1 expression in Sertoli cells. Further analyses using deletion constructs revealed that a 1.5 kb region 5′ to the GATA-1 haematopoietic enhancer is essential for gene expression in Sertoli cells and this region is referred to as the GATA-1 testis activation region. Conclusion: These results thus demonstrated that the GATA-1 testis activation region is essential for Sertoli cell-specific expression of GATA-1 gene. The 15 kb genomic region is applicable and useful for the expression vector system specific for adult Sertoli cells in stage VII to IX.en_US
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dc.publisherBlackwell Science Ltden_US
dc.rights© Blackwell Publishing Limiteden_US
dc.titleGATA-1 testis activation region is essential for Sertoli cell-specific expression of GATA-1 gene in transgenic mouseen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109-0616, USAen_US
dc.contributor.affiliationotherCentre for Tsukuba Advanced Research Alliance,en_US
dc.contributor.affiliationotherInstitute of Basic Medical Sciences,en_US
dc.contributor.affiliationotherCentre for Animal Resource Research anden_US
dc.contributor.affiliationotherInstitute of Clinical Medical Sciences, University of Tsukuba, Tsukuba 305-8577, Japan,en_US
dc.contributor.affiliationotherExploratory Research for Advanced Technology, Japan Science and Technology Corporation,en_US
dc.contributor.affiliationotherInstitute of Microbial Disease, Osaka University, Suita 565-0871, Japanen_US
dc.identifier.pmid12839622en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/71393/1/j.1365-2443.2003.00658.x.pdf
dc.identifier.doi10.1046/j.1365-2443.2003.00658.xen_US
dc.identifier.sourceGenes to Cellsen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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