Gender mix in twins and fetal growth, length of gestation and adult cancer risk
dc.contributor.author | Luke, Barbara | en_US |
dc.contributor.author | Hediger, Mary | en_US |
dc.contributor.author | Min, Sung-Joon | en_US |
dc.contributor.author | Brown, Morton B. | en_US |
dc.contributor.author | Misiunas, Ruta B. | en_US |
dc.contributor.author | Gonzalez-Quintero, Victor Hugo | en_US |
dc.contributor.author | Nugent, Clark E. | en_US |
dc.contributor.author | Witter, Frank R. | en_US |
dc.contributor.author | Newman, Roger B. | en_US |
dc.contributor.author | Hankins, Gary D. V. | en_US |
dc.contributor.author | Grainger, David A. | en_US |
dc.contributor.author | Macones, George A. | en_US |
dc.date.accessioned | 2010-06-01T18:20:24Z | |
dc.date.available | 2010-06-01T18:20:24Z | |
dc.date.issued | 2005-01 | en_US |
dc.identifier.citation | Luke, Barbara; Hediger, Mary; Min, Sung-Joon; Brown, Morton B.; Misiunas, Ruta B.; Gonzalez-Quintero, Victor Hugo; Nugent, Clark; Witter, Frank R.; Newman, Roger B.; Hankins, Gary D. V.; Grainger, David A.; Macones, George A. (2005). "Gender mix in twins and fetal growth, length of gestation and adult cancer risk." Paediatric and Perinatal Epidemiology 19(s1): 41-47. <http://hdl.handle.net/2027.42/71549> | en_US |
dc.identifier.issn | 0269-5022 | en_US |
dc.identifier.issn | 1365-3016 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/71549 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15670121&dopt=citation | en_US |
dc.description.abstract | This study evaluated the effect of gender mix (the gender combinations of twin pairs) on fetal growth and length of gestation, and reviewed the literature on the long-term effects of this altered fetal milieu on cancer risk. In singletons, it is well established that females weigh less than males at all gestations, averaging 125–135 g less at full term. This gender difference is generally believed to be the result of the effect of androgens on fetal growth. The gender difference in fetal growth is greater before the third trimester and less towards term, with males growing not only more, but also earlier than females. Plurality is a known risk factor for reduced fetal growth and birthweight. Compared with singletons, the mean birthweight percentiles of twins fall substantially (by 10% or more) below the singleton 10th percentile by 28 weeks, below the singleton 50th percentile by 30 weeks, and below the singleton 90th percentile by 34 weeks. In unlike-gender twin pairs, it has been reported that the female prolongs gestation for her brother, resulting in a higher birthweight for the male twin than that of like-gender male twins. Other researchers have demonstrated that females in unlike-gender pairs had higher birthweights than females in like-gender pairs. Analyses from our consortium on 2491 twin pregnancies with known chorionicity showed longer gestations and faster rates of fetal growth in both males and females in unlike-gender pairs compared with like-gender male or female pairs, although these differences were not statistically significant. The post-natal effects for females growing in an androgenic-anabolic environment include increased sensation-seeking behaviour and aggression, lowered visual acuity, more masculine attitudes and masculinising effects of the auditory system and craniofacial growth. In contrast, there is no evidence to suggest that there might be a similar feminising effect on males from unlike-gender pairs. This hormonal exposure in utero may influence adult body size and susceptability to breast cancer. | en_US |
dc.format.extent | 82395 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Science Ltd | en_US |
dc.rights | 2005 Blackwell Publishing Ltd | en_US |
dc.title | Gender mix in twins and fetal growth, length of gestation and adult cancer risk | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department Of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, | en_US |
dc.contributor.affiliationum | Department of Obstetrics & Gynecology, University of Michigan Medical School, Ann Arbor, MI, | en_US |
dc.contributor.affiliationother | Department of Epidemiology and Public Health, University of Miami School of Medicine, Miami, FL, | en_US |
dc.contributor.affiliationother | Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, National Institutes of Health, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD, | en_US |
dc.contributor.affiliationother | Division of Health Care Policy and Research, University of Colorado Health Sciences Center, Denver, CO, | en_US |
dc.contributor.affiliationother | Department of Obstetrics & Gynecology, University of Miami School of Medicine, Miami, FL, | en_US |
dc.contributor.affiliationother | Department of Gynecology & Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, | en_US |
dc.contributor.affiliationother | Department of Obstetrics & Gynecology, Medical University of South Carolina, Charleston, SC, | en_US |
dc.contributor.affiliationother | Department of Obstetrics & Gynecology, University of Texas Medical Branch at Galveston, TX, | en_US |
dc.contributor.affiliationother | Department of Obstetrics & Gynecology, University of Kansas Medical School, Wichita, KS, and | en_US |
dc.contributor.affiliationother | Department of Obstetrics & Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA | en_US |
dc.identifier.pmid | 15670121 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/71549/1/j.1365-3016.2005.00616.x.pdf | |
dc.identifier.doi | 10.1111/j.1365-3016.2005.00616.x | en_US |
dc.identifier.source | Paediatric and Perinatal Epidemiology | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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