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Evidence for local control of gene expression in the epidermal differentiation complex

dc.contributor.authorElder, James T.en_US
dc.contributor.authorZhao, Xinpingen_US
dc.date.accessioned2010-06-01T18:23:04Z
dc.date.available2010-06-01T18:23:04Z
dc.date.issued2002-10en_US
dc.identifier.citationElder, James T.; Zhao, Xinping (2002). "Evidence for local control of gene expression in the epidermal differentiation complex ." Experimental Dermatology 11(5): 406-412. <http://hdl.handle.net/2027.42/71593>en_US
dc.identifier.issn0906-6705en_US
dc.identifier.issn1600-0625en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/71593
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12366693&dopt=citationen_US
dc.description.abstractThe epidermal differentiation complex (EDC), located on chromosomal band 1q21, consists of at least 43 genes that are expressed during keratinocyte differentiation. Indicative of a role for chromatin structure in tissue specificity of EDC gene expression, we identified an inverse correlation between expression and DNA methylation for two EDC genes (S100A2 and S00A6) in human keratinocytes and fibroblasts. 5-azacytidine (5AC) and sodium butyrate (NaB) are two agents known to promote ‘open’ chromatin structure. To explore the relationship between chromatin structure and keratinocyte differentiation, we treated normal human keratinocytes (NHK) with 5AC or NaB, or with protocols known to promote their terminal differentiation. We then measured the steady-state mRNA levels for several S100 genes, small proline rich region-1, -2, and -3, loricrin, and involucrin by Northern blotting. 5AC and NaB each markedly increased expression of SPRR1/2 and involucrin in NHK. In contrast, expression of S100A2 was reduced by both agents, and by induction of keratinocyte differentiation. Moreover, while the clustered EDC genes displayed a general tendency to be expressed in epithelial cells, they displayed different patterns of cell type-specific expression. These results indicate that local, gene-specific factors play an important role in the regulation of EDC gene expression in the keratinocyte lineage and during keratinocyte terminal differentiation.en_US
dc.format.extent195270 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherMunksgaard International Publishersen_US
dc.publisherBlackwell Publishing Ltden_US
dc.rights© Blackwell Munksgaard 2002en_US
dc.subject.otherHistone Acetylationen_US
dc.subject.otherS100 Genesen_US
dc.subject.otherSodium Butyrateen_US
dc.subject.otherSPRR Genesen_US
dc.titleEvidence for local control of gene expression in the epidermal differentiation complexen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelDentistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Dermatology and Radiation Oncology (Cancer Biology), University of Michigan,en_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationotherAnn Arbor Veterans Affairs Hospital, Ann Arbor, MI, anden_US
dc.identifier.pmid12366693en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/71593/1/j.1600-0625.2002.110503.x.pdf
dc.identifier.doi10.1034/j.1600-0625.2002.110503.xen_US
dc.identifier.sourceExperimental Dermatologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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