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NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala
dc.contributor.authorGoosens, Ki A.en_US
dc.contributor.authorMaren, Stephenen_US
dc.date.accessioned2010-06-01T18:33:47Z
dc.date.available2010-06-01T18:33:47Z
dc.date.issued2004-07en_US
dc.identifier.citationGoosens, Ki A.; Maren, Stephen (2004). "NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala." European Journal of Neuroscience 20(2): 537-548. <http://hdl.handle.net/2027.42/71768>en_US
dc.identifier.issn0953-816Xen_US
dc.identifier.issn1460-9568en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/71768
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15233763&dopt=citationen_US
dc.description.abstractWe examined the contribution of N -methyl-D-aspartate (NMDA) receptors (NMDARs) to the acquisition and expression of amygdaloid plasticity and Pavlovian fear conditioning using single-unit recording techniques in behaving rats. We demonstrate that NMDARs are essential for the acquisition of both behavioral and neuronal correlates of conditional fear, but play a comparatively limited role in their expression. Administration of the competitive NMDAR antagonist ±-3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP) prior to auditory fear conditioning completely abolished the acquisition of conditional freezing and conditional single-unit activity in the lateral amygdala (LA). In contrast, CPP given prior to extinction testing did not affect the expression of conditional single-unit activity in LA, despite producing deficits in conditional freezing. Administration of CPP also blocked the induction of long-term potentiation in the amygdala. Together, these data suggest that NMDARs are essential for the acquisition of conditioning-related plasticity in the amygdala, and that NMDARs are more critical for regulating synaptic plasticity and learning than routine synaptic transmission in the circuitry supporting fear conditioning.en_US
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dc.format.extent3109 bytes
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dc.publisherBlackwell Science Ltden_US
dc.rights2004 Federation of European Neuroscience Societiesen_US
dc.subject.otherCPPen_US
dc.subject.otherFreezingen_US
dc.subject.otherGlutamateen_US
dc.subject.otherLong-term Potentiationen_US
dc.subject.otherRaten_US
dc.titleNMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdalaen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychology, University of Michigan, Ann Arbor, Michigan 48109-1109, USAen_US
dc.contributor.affiliationumNeuroscience Program, University of Michigan, Ann Arbor, Michigan 48109-1109, USAen_US
dc.identifier.pmid15233763en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/71768/1/j.1460-9568.2004.03513.x.pdf
dc.identifier.doi10.1111/j.1460-9568.2004.03513.xen_US
dc.identifier.sourceEuropean Journal of Neuroscienceen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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