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Substantia nigra pars reticulata neurons code initiation of a serial pattern: implications for natural action sequences and sequential disorders
dc.contributor.authorMeyer-Luehmann, Melanieen_US
dc.contributor.authorThompson, Jeffrey F.en_US
dc.contributor.authorBerridge, Kent C.en_US
dc.contributor.authorAldridge, J. Wayneen_US
dc.date.accessioned2010-06-01T18:35:35Z
dc.date.available2010-06-01T18:35:35Z
dc.date.issued2002-10en_US
dc.identifier.citationMeyer-Luehmann, Melanie; Thompson, Jeffrey F.; Berridge, Kent C.; Aldridge, J. Wayne (2002). "Substantia nigra pars reticulata neurons code initiation of a serial pattern: implications for natural action sequences and sequential disorders." European Journal of Neuroscience 16(8): 1599-1608. <http://hdl.handle.net/2027.42/71795>en_US
dc.identifier.issn0953-816Xen_US
dc.identifier.issn1460-9568en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/71795
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12405974&dopt=citationen_US
dc.description.abstractSequences of movements are initiated abnormally in neurological disorders involving basal ganglia dysfunction, such as Parkinson's disease or Tourette's syndrome. The substantia nigra pars reticulata (SNpr) is one of the two primary output structures of the basal ganglia. However, little is known about how substantia nigra mediates the initiation of normal movement sequences. We studied its role in coding initiation of a sequentially stereotyped but natural movement sequence by recording neuronal activity in SNpr during behavioural performance of ‘syntactic grooming chains’. These are rule-governed sequences of up to 25 grooming movements emitted in four predictable (syntactic) phases, which occur spontaneously during grooming behaviour by rats and other rodents. Our results show that neuronal activation in central SNpr codes the onset of this entire rule-governed sequential pattern of grooming actions, not elemental grooming movements. We conclude that the context of sequential pattern may be more important than the elemental motor parameters in determining SNpr neuronal activation.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Science Ltden_US
dc.rightsFederation of European Neuroscience Societiesen_US
dc.subject.otherBasal Gangliaen_US
dc.subject.otherDopamineen_US
dc.subject.otherFixed Action Patternen_US
dc.subject.otherGroomingen_US
dc.subject.otherHuntington's Diseaseen_US
dc.subject.otherMovement Sequencesen_US
dc.subject.otherMovementen_US
dc.subject.otherNeuroethologyen_US
dc.subject.otherNeuronal Activityen_US
dc.subject.otherObsessive–Compulsive Disorderen_US
dc.subject.otherParkinson's Diseaseen_US
dc.subject.otherRaten_US
dc.subject.otherSerial Orderen_US
dc.subject.otherSyntaxen_US
dc.subject.otherTourette's Syndromeen_US
dc.titleSubstantia nigra pars reticulata neurons code initiation of a serial pattern: implications for natural action sequences and sequential disordersen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychology, University of Michigan, Ann Arbor, MI 48109–1109, USAen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109–0489, USAen_US
dc.contributor.affiliationotherDepartment of Neuropathology, University of Basel, Switzerlanden_US
dc.contributor.affiliationotherPhysiological Science, 4117 LSB, University of California, Los Angeles, Los Angeles, CA 90095–1606, USAen_US
dc.identifier.pmid12405974en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/71795/1/j.1460-9568.2002.02210.x.pdf
dc.identifier.doi10.1046/j.1460-9568.2002.02210.xen_US
dc.identifier.sourceEuropean Journal of Neuroscienceen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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