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Dental pulp cells provide neurotrophic support for dopaminergic neurons and differentiate into neurons in vitro ; implications for tissue engineering and repair in the nervous system

dc.contributor.authorNosrat, Irina V.en_US
dc.contributor.authorSmith, Christopher A.en_US
dc.contributor.authorMullally, Patricken_US
dc.contributor.authorOlson, Larsen_US
dc.contributor.authorNosrat, Christopher A.en_US
dc.date.accessioned2010-06-01T18:36:26Z
dc.date.available2010-06-01T18:36:26Z
dc.date.issued2004-05en_US
dc.identifier.citationNosrat, Irina V.; Smith, Christopher A.; Mullally, Patrick; Olson, Lars; Nosrat, Christopher A. (2004). "Dental pulp cells provide neurotrophic support for dopaminergic neurons and differentiate into neurons in vitro ; implications for tissue engineering and repair in the nervous system." European Journal of Neuroscience 19(9): 2388-2398. <http://hdl.handle.net/2027.42/71809>en_US
dc.identifier.issn0953-816Xen_US
dc.identifier.issn1460-9568en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/71809
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15128393&dopt=citationen_US
dc.description.abstractGlial cell line-derived neurotrophic factor (GDNF) mRNA is highly expressed by dental pulp cells (DPCs) prior to the initiation of dental pulp innervation. We show that radioactively labelled exogenous GDNF is retrogradely transported from neonatal teeth and vibrissae to the trigeminal neurons, indicating that GDNF acts as a classical neurotrophic factor in the trigeminal system. We also show that DPCs from both rats and humans produce nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and GDNF mRNAs in vitro , promote the survival and phenotypic characteristics of embryonic dopaminergic (DA) neurons and protect DA neurons against the neurotoxin 6-hydroxy-dopamine (6-OHDA) in vitro . By using inhibitory antibodies to NGF, BDNF and GDNF, we show that the promotion of DA neuron survival relates to the production and release of neurotrophic proteins by DPCs in vitro . We suggest that in vivo production of neurotrophic factors by DPCs play roles in tooth innervation. However, continued production of neurotrophic factors by the DPCs might have wider implications. We propose that the dental pulp is a viable source of easily attainable cells with possible potential for development of autologous cell transplantation therapies. We also show that a population of neural crest-derived dental pulp cells acquire clear neuronal morphology and protein expression profile in vitro , indicating the presence of a cell population in the dental pulp with neuronal differentiation capacity that might provide additional benefits when grafted into the CNS.en_US
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dc.format.extent3109 bytes
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dc.publisherBlackwell Science Ltden_US
dc.rights© Federation of European Neuroscience Societiesen_US
dc.subject.otherBDNFen_US
dc.subject.otherDopamineen_US
dc.subject.otherGDNFen_US
dc.subject.otherNeurotrophic Factorsen_US
dc.subject.otherNGFen_US
dc.subject.otherTooth Innervationen_US
dc.titleDental pulp cells provide neurotrophic support for dopaminergic neurons and differentiate into neurons in vitro ; implications for tissue engineering and repair in the nervous systemen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumLaboratory of Oral Neurobiology, Department of Biologic and Materials Sciences, Room 3218, School of Dentistry, University of Michigan, Ann Arbor, MI 48109–1078, USAen_US
dc.contributor.affiliationotherDepartment of Neuroscience, Karolinska Institutet, Stockholm, Swedenen_US
dc.identifier.pmid15128393en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/71809/1/j.0953-816X.2004.03314.x.pdf
dc.identifier.doi10.1111/j.0953-816X.2004.03314.xen_US
dc.identifier.sourceEuropean Journal of Neuroscienceen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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